Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 511-530 of 1169
-
Lab-on-chip design to characterize pore-spanning lipid bilayers
(2013-11-26)A powerful approach to study membrane proteins is the reconstitution in model membranes. Methods for arti cial bilayer formation are e.g. membranes on a solid support, or the classical BLM. In this project, the focus was ... -
Leaf Venation Networks
(2016-02-23)Understanding the leaf venation network is a multifaceted endeavor that requires tools from several fields of study. This thesis addresses a broad range of questions, all guided by a central theme: “How does the geometry ... -
Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Linking senses: the genetics of Drosophila larval chordotonal organs
(2018-08-06)Sensory systems have evolved in all organisms to detect changes in the environment or their internal state. Even though they are essential for fitness and survival, their phylogenisis is still unclear. The protosensory ... -
Lipid dependent interactions of biomimetic membrane models with the ENTH domain of epsin
(2020-02-05)Membrane remodeling processes during endocytosis are highly regulated by the protein-protein and protein-membrane interactions. In clathrin-mediated endocyto-sis (CME) binding of the protein epsin to its receptor lipid ... -
Lipid organisation and dynamics in the myelin membrane sheets
(2014-07-25)Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal ... -
Lipids in plant development and stress responses
(2023-08-22)In plant cells, lipids are important components of cellular membranes. There, they act as structure-forming and/or signal-transmitting elements. As signals, lipids are landmarks and thereby important regulators, for example ... -
Live imaging of autoimmune responses in distinct milieus of the central nervous system
(2013-08-28)Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS). Even though it is considered to be a classical demyelinating disease, an increasing body of evidence also demonstrates ... -
Localisation and function of Slam in the early Drosophila embryo
(2014-11-06)Embryogenesis of many insects starts with a syncytial stage characterised by 13 rapid nuclear divisions. During the following interphase, the plasma membrane of the embryo invaginates between each nucleus to give rise to ... -
Long-Term Temporal Dynamics of Synaptic Vesicles
(2017-09-11)Neurotransmission requires the release of neurotransmitters from synaptic vesicles. This occurs via fusion of the vesicle to the pre-synaptic membrane upon stimulation. However, not all synaptic vesicles are equally ... -
Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
(2018-11-15)Defects in metabolism result in various diseases, with neurodegeneration being one of the most prevalent consequences. Mitochondria and lysosomes are long known to be fundamental for cellular metabolism. In addition to ... -
Machine learning classification of patients with major depressive disorder and healthy controls using magnetic resonance imaging data
(2023-04-19)Major depressive disorder (MDD) is a prevalent and complex psychiatric disorder affecting more than 300 million people worldwide. It is characterized by a highly heterogeneous spectrum of symptoms, including low mood and ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ... -
Mad2l2 as a safeguard for open chromatin in embryonic stem cells
(2016-08-08)Open chromatin is induced locally during the repair of DNA double-strand breaks when a cascade of protein recruitments and modifications is triggered. This "ATM cascade" includes components like the Mrn complex, ATM kinase, ... -
Mad2l2 in primordial germ cell development and pluripotency
(2013-11-18)The development of primordial germ cells (PGCs) involves several waves of epigenetic reprogramming. A major step is the transition from the stably suppressive histone modification H3K9me2 to the more flexible, still ... -
Maintenance of glutamate homeostasis in Bacillus subtilis by complex regulatory systems and genomic adaptation
(2017-10-16)The Gram-positive model organism Bacillus subtilis lives in the soil and must cope with a constantly changing environment. Glutamate plays an important role in cellular metabolism, because it is the major amino group ... -
Manipulating co-regulators of RUNX2 and SOX9 to enhance the chondrogenic potential of chondrogenic progenitor cells in osteoarthritis
(2020-12-11)Osteoarthritis (OA) is a degenerative disease of the joint leading to the degradation of the articular cartilage. Current therapies cannot halt or reverse the disease, leading to a severe impact on life quality accompanied ... -
Manipulating neuronal communication by using low-intensity repetitive transcranial magnetic stimulation combined with electroencephalogram
(2021-11-18)Repetitive transcranial magnetic stimulation (rTMS) modulates ongoing brain rhythms by activating neuronal structures and evolving different neuronal mechanisms. In the current work, the role of stimulation strength and ... -
Margin learning in spiking neural networks
(2018-11-29)The ability to learn, generalize and reliably detect features embedded in continuous sensory input streams is a crucial function of the central nervous system. Sensory neurons process input from thousands of synapses ... -
Mathematical modeling of the structure and function of inner hair cell ribbon synapses
(2017-02-03)Information about the auditory world enters the mammalian brain through ribbon synapses of inner hair cells. Due to their fundamental role in auditory processing, these nanoscopic structures have recently received a lot ...