Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 520-539 of 1165
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Machine learning classification of patients with major depressive disorder and healthy controls using magnetic resonance imaging data
(2023-04-19)Major depressive disorder (MDD) is a prevalent and complex psychiatric disorder affecting more than 300 million people worldwide. It is characterized by a highly heterogeneous spectrum of symptoms, including low mood and ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ... -
Mad2l2 as a safeguard for open chromatin in embryonic stem cells
(2016-08-08)Open chromatin is induced locally during the repair of DNA double-strand breaks when a cascade of protein recruitments and modifications is triggered. This "ATM cascade" includes components like the Mrn complex, ATM kinase, ... -
Mad2l2 in primordial germ cell development and pluripotency
(2013-11-18)The development of primordial germ cells (PGCs) involves several waves of epigenetic reprogramming. A major step is the transition from the stably suppressive histone modification H3K9me2 to the more flexible, still ... -
Maintenance of glutamate homeostasis in Bacillus subtilis by complex regulatory systems and genomic adaptation
(2017-10-16)The Gram-positive model organism Bacillus subtilis lives in the soil and must cope with a constantly changing environment. Glutamate plays an important role in cellular metabolism, because it is the major amino group ... -
Manipulating co-regulators of RUNX2 and SOX9 to enhance the chondrogenic potential of chondrogenic progenitor cells in osteoarthritis
(2020-12-11)Osteoarthritis (OA) is a degenerative disease of the joint leading to the degradation of the articular cartilage. Current therapies cannot halt or reverse the disease, leading to a severe impact on life quality accompanied ... -
Manipulating neuronal communication by using low-intensity repetitive transcranial magnetic stimulation combined with electroencephalogram
(2021-11-18)Repetitive transcranial magnetic stimulation (rTMS) modulates ongoing brain rhythms by activating neuronal structures and evolving different neuronal mechanisms. In the current work, the role of stimulation strength and ... -
Margin learning in spiking neural networks
(2018-11-29)The ability to learn, generalize and reliably detect features embedded in continuous sensory input streams is a crucial function of the central nervous system. Sensory neurons process input from thousands of synapses ... -
Mathematical modeling of the structure and function of inner hair cell ribbon synapses
(2017-02-03)Information about the auditory world enters the mammalian brain through ribbon synapses of inner hair cells. Due to their fundamental role in auditory processing, these nanoscopic structures have recently received a lot ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Maturation of ribbon synapses in hair cells is driven by thyroid hormone
(2007-06-07)Ribbon synapses of inner hair cells (IHCs) undergo developmental maturation until after the onset of hearing. Here, we studied whether IHC synaptogenesis is regulated by thyroid hormone ... -
MDM2 as a chromatin modifier
(2020-09-08)Since its discovery about 40 years ago, the transcription factor p53 has turned into the most extensively studied protein in the context of human cancers due to its essential role in promoting tumor suppression. P53 ... -
Mechanical Properties of the lch5 Organ in the Drosophila Larva
(2017-09-08)I begin with a brief account of the topic of mechanosensation, followed by an outline of how the project evolved. The experimental techniques used and their rationale are described. The section ends with a short description ... -
Mechanics and Dynamics of <i>Dictyostelium discoideum</i> adhesion
(2021-09-28)The amoeba Dictyostelium discoideum (D.d.) is an excellent laboratory model system for studying amoeboid adhesion. In its natural habitat, D.d. lives in the soil and hunts for bacteria, an environment, which ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Mechanics of suspended cells probed by dual optical traps in a confocal microscope
(2015-12-02)Cells are sensitive to mechanical cues from their environment and at the same time generate and transmit forces to their surroundings. In this thesis, we quantitatively measured forces and elastic spring constants of ... -
Mechanism of Germ Cell Specification in Early Zebrafish Embryogenesis
(2021-07-19)Reproduction is an essential feature of life that ensures the perpetuation and survival in many multicellular organisms while passing the genetic information to the next generation. The zebrafish germline is specified ... -
Mechanism of non-canonical ubiquitination by ubiquitin conjugating enzyme Ubc6
(2023-10-18)Protein quality control by ubiquitination occurs due to the sequential action of three enzyme classes: ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligases (E3). Conventionally, ubiquitin (Ub) ... -
Mechanism of regulation of spliceosome activation by Brr2 and Prp8 and links to retinal disease
(2013-11-12)Splicing is a crucial post-transcriptional processing event that entails the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNA and the ligation of the coding sequences (exons). It is carried ... -
Mechanism of Ribosome Rescue by Alternative Release Factor B
(2020-07-09)Rescue of ribosomes stalled on non-stop mRNAs is essential in bacteria and in the mitochondria of all eukaryotes. The lack of a stop codon causes ribosomes to stall at the 3’ end of mRNA with an empty A site, and specialized ...