Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 653-672 of 1169
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N-truncated Aβ4-x peptides in Alzheimer's disease: generation, degradation, and relationship with neuropathological hallmarks
(2021-12-20)Amyloid pathology in Alzheimer’s disease (AD) is characterized by a heterogeneity of amyloid-β peptides (Aβ) variants. The N-terminally truncated Aβ4-42 peptides are among the most abundant species and were reported having ... -
Nanobodies as new tools for studying large cargo transport and lamina organization
(2018-06-26)Nanobodies are the smallest recombinantly expressed antibody fragments, which show outstanding performance in numerous applications. In this work, we set out to generate nanobodies as tools to study nucleo-cytoplasmic ... -
Nanoscale Brownian Dynamics of Semiflexible Biopolymers
(2020-07-24)Proteins are one of, if not the most, versatile of biology’s tools, performing a great variety of functions in living organisms and giving rise to behavior as complex as life itself. They are linear chains of amino acids ... -
Nanoscale organization and dynamics of SNARE proteins in the presynaptic membranes
(2015-10-19)The specific organization of proteins and lipids in functional domains in biological membranes allows localization and segregation of specific physiological activities. Mechanisms that underlie the formation of these domains ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ... -
Nanoscale Photonics
(2017-08-14)Detecting single nanometre scale objects and studying them in a controlled manner in solution is still a difficult task due to diffusion. We demonstrate one-dimensional nanofluidic flows of single molecules by confining ... -
Nanoscale probing of single synapse function and BDNF Cell-to-Cell transfer
(2016-12-22)Brain-derived neurotrophic factor (BDNF) is one of the key modulator/mediator molecules for synaptic plasticity in the adult nervous system and also coordinates neural development, survival, differentiation and axon growth ... -
Nanoscopy inside living brain slices
(2014-10-30)In order to understand how memory is processed and stored in the brain, it would be helpful to observe the ongoing memory processes in action. This is no easy task, however, if it is to be done at the synaptic level. It ... -
NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity
(2014-03-31)The work presented in this thesis is centered on characterizing macroscopic electrophysiological instabilities observed at the tissue level that emanate from perturbations affecting essentially the NaV1.5 channel in the ... -
Network Dynamics as an Inverse Problem
(2016-12-16)In this thesis, we take a general view on the study of networks from inverse perspectives. By proposing a general representation for the dynamics of networks in terms of explicit dependencies among units, we develop new ... -
Network Formation and Dynamics under Economic Constraints
(2018-03-26)Networks describe a broad range of systems across a wide variety of topics from social and economic interactions over technical infrastructures such as power grids and the internet to biological contexts such as food webs ... -
Network formation and reorganization of the olfactory system of Xenopus laevis
(2022-03-03)The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
"Eine neue Rolle für Myelin-assoziierte Inhibitoren für die Mobilität von Mikroglia"
(2009-05-28)In the central nervous system of mammals, the regeneration of axons after injury is limited. The reduced ability of neurite outgrowth can be attributed, in part, to the presence of inhibitor proteins enriched in myelin. ... -
Neural basis of rule-based decisions with graded choice biases
(2016-07-22)In every hour of every day we are faced with options; which route to take to work, where to go for a meal, which stocks to invest in. However, with limitations of movement, time and budget, our options are constrained. We ... -
Neural circuit plasticity underlying learning and memory in Drosophila melanogaster: from synaptic connections to behavior
(2023-05-12)Understanding the principles behind olfactory higher-order associative chains formation in Drosophila is one step further into unraveling the essence of learning and memory. However, the rationale behind such mechanisms ... -
Neural coding of grasp force planning and control in macaque areas AIP, F5, and M1
(2016-10-27)Much research has been done in the last decades to decipher how the brain controls grasping movements. The anterior intraparietal area (AIP), the hand area of the ventral premotor cortex (F5), and the hand area of the ... -
Neural correlates of action effects anticipation – towards ecological more relevant paradigms
(2023-12-07)Imagine it is Saturday morning and you are going for groceries with your car. Once you arrive at the supermarket, you attempt to reverse park your car in a narrow parking space. You have learned in school, if you want ... -
Neural correlates of conscious visual processing
(2021-06-01)The objective of the current thesis is to evaluate the role of alpha band activity and neural trial-to-trial variability in conscious visual perception and their relationship to each other. We investigate these measures ... -
Neural network integration from multimodal imaging in epilepsy and healthy controls
(2024-01-17)Different imaging modalities can be used to probe distinct aspects of the brain, such as cerebral anatomy (MRI), tissue diffusion directions (DTI), metabolic activity (PET), neurovascular activity (fMRI), or electrophysiological ...