Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 740-759 of 1164
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Pair-correlation effects in many-body systems
(2023-05-25)The laws of nature encompass the small, the large, the few, and the many. In this thesis we are concerned with classical (i.e. not quantum) many-body systems, which refers to any microscopic or macroscopic system that ... -
Pairing transcranial direct current stimulation and mindfulness meditation in the treatment of fibromyalgia
(2024-08-22)The lack of effective treatments for managing pain and associated symptoms in fibromyalgia (FM) poses both a clinical challenge and an economic burden on the health sector. Typical FM therapies include an array of ... -
Pancreatic β-Cell Regeneration in TIF-IA Knockout Mice
(2014-09-30)As the sole source of insulin production in body, pancreatic β-cells play an essential role in glucose homeostasis. Diabetes mellitus is a chronic disease characterized by loss, reduction, and/or malfunction of β-cell mass. ... -
Paramagnetic Tagging of Oligonucleotides for Structure Determination using NMR-Spectroscopy
(2015-03-31)Structure determination is one of the most fundamental fields of research, as it provides insights in biological systems and their mechanisms. Therein, NMR spectroscopy is an essential tool for investigations under ... -
Paramagnetic tools for the structural analysis of high molecular weight proteins
(2015-12-10)Paramagnetic effects provide important structural and dynamic information of biomolecules. However, the attachment of lanthanides through small chelating organic molecules to proteins (the most common way to obtain ... -
Pathogen-induced cell wall remodeling and production of Danger Associated Molecular Patterns (DAMPs)
(2020-08-25)For a plant pathogen, overcoming the plant cell wall is crucial for a successful infection. Thus, pathogens evolved different strategies to invade their host plants. These include entry through natural openings such as ... -
Pathological Alterations Induced by intraneuronal in Alzheimer’s Disease
(2010-01-18)Alzheimer’s disease (AD) is pathologically characterized by the deposition of amyloid beta (Aβ) and neurofibrillary tangles (NFT) consisting of hyperphosphorylated tau protein. Since familial mutations in proteins ... -
Pathophysiological Characterization of intra‐ and extracellularly aggregated Amyloid Peptides in Dementias
(2013-06-28)Alzheimer’s Disease (AD) is the most common form of dementia in the elderly population and is neuropathologically characterized by hippocampal neurofibrillary degeneration, chronic inflammation as well as widespread ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Pathway and network analyses in context of Wnt signaling in breast cancer
(2016-03-01)A complex network of interplaying signaling pathways governs cell behavior and phenotype. Wnt signaling pathways are part of this network and play an important role in embryonic development as well as in carcinogenesis. ... -
Pathways for phospholipid deacylation in Saccharomyces cerevisiae and their impact on fatty acid trafficking and equilibrium
(2011-01-25)The phospholipid (PL) class and species composition is a fundamental characteristic of membranes, essential to their proper function. The PL species distribution of cellular lipids is only ... -
Perception of visual motion speed in human und monkey
(2007-06-27)Perception of motion is crucial for the survival of most animals, as well as of humans. It has been shown that a number of stimulus factors can influence the visual perception of motion ... -
Perceptual and motor intentional processing in dorsal pulvinar
(2019-06-27)The pulvinar is the largest thalamic structure in the center of the brain, reciprocally connected to a large diversity of cortical areas. It has grown more than other subcortical structures during primate evolution, which ... -
Peripheral nervous system control for neuroprostheses
(2017-09-21)Amputee patients who have lost a hand or arm are severely impaired in their daily life, as they lose the ability to grasp and interact with their environment. While the use of electromyographically controlled prosthetic ... -
Perturbation Growth and Prediction of Extreme Events
(2018-11-15)Extreme events occur in a variety of dynamical systems. Here we employ quantifiers of chaos to identify changes in the dynamical structure of complex systems preceding an extreme event. -
Perturbation of Pattern Formation in Dictyostelium Discoideum via Flow and Spatial Heterogeneities
(2020-04-07)In this thesis, we investigate the signalling process of the social amoeba Dictyostelium discoideum (D. discoideum) as a model reaction-diffusion-advection system. Colonies of these cells are an excitable medium that ... -
Pharmacological alterations of neuroplasticity in the human motor cortex induced by dopaminergic and cholinergic agents
(2011-03-03)Dopamine and Acetylcholine are the major neuromodulators in the human central nervous system which strongly influence neuroplasticity. Several factors including subreceptor specificity, ... -
Pharmacologically controlled neurotrophic factor gene therapy for Parkinson's disease
(2019-07-24)During the PhD thesis, two projects were carried out. In the first project, an inducible AAV-5 vector for expression of GDNF, under control of the approved small molecule drug mifepristone, was evaluated in rats. GDNF ... -
Pharmacotreatment of a mouse model of Rett syndrome with the radical scavenger Trolox: Detailed assessment of potential merits in vitro and in vivo
(2015-04-27)Rett syndrome is a severe neurodevelopmental disorder, with an incidence of ~1/1000 female births, in which most patients carry mutations in the methyl-CpG binding protein 2 gene. No cure exists so far. Rett girls are born ... -
Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ...