Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 793-812 of 1164
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Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Quantifying Evolutionary Dynamics
(2015-06-04)Adaptation is a central process in evolution: populations adapt to their environment by accumulating beneficial mutations over the course of generations. Microbial populations present an excellent experimental system that ... -
Quantifying the diffusion of membrane proteins and peptides
(2013-08-15)Lipid and protein diffusion in membranes is a fundamental requirement for many signaling processes in biological cells. Therefore, measuring protein and lipid mobility in lipid bilayers with high accuracy is essential for ... -
Quantifying topological transformation in lipid self-assemblies
(2021-06-03)Surfactant assemblies are characterized by soft intermolecular interactions and can be deformed or topologically altered by thermal or mechanical stress of the magnitude of thermal fluctuations. In biology, the protein ... -
Quantitation Strategies in Optically Sectioning Fluorescence Microscopy
(2009-06-15)The development of microscopes that can record fluorescence intensity in five and more dimensions in one experiment (e.g. space, time and colour) makes parameters available for the scientific ... -
Quantitative analysis of Förster resonance energy transfer from spectrally resolved fluorescence measurements
(2010-08-25)A novel method for spectral analysis of Forster resonance energy transfer (FRET) signals is presented. This method provides a general solution for donor quenching and acceptor sensitization ... -
Quantitative Modeling of RNA-Protein Interactions
(2021-05-07)RNA-binding proteins (RBPs) impact every aspect of RNA metabolism including RNA transcription, maturation, export, localization, translation, and stability. Specific RNA-protein interactions therefore play a central role ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ... -
Quantitative Multi-Parameter Mapping in Magnetic Resonance Imaging
(2023-08-18)Magnetic resonance imaging (MRI) is a versatile imaging technology with a broad variety of biomedical and clinical applications. It provides an excellent soft tissue contrast without the need for ionizing radiation or ... -
Quantitative Multicolour Nanoscopy for the Investigation of the Postsynaptic Actin Cytoskeleton
(2023-08-16)Cognitive processes like the formation of memory and learning originate in the correct functioning of synapses. Dendritic spines are highly plastic, specialised actin-rich structures harbouring the postsynaptic site in ... -
Quantitative Nanoscopy of Synaptic Sites
(2023-08-23)Synapses are the basic information processing unit of the brain. Neuronal activity and memory formation thereby require a vastly dynamic and rapidly changing synaptic environment and composition. In order to function, these ... -
Quantitative phosphoproteomics for studying B-cell receptor signaling in Burkitt’s lymphoma
(2017-02-16)Protein phosphorylation plays an important role in transmitting cellular signals. Phosphorylation has been mostly characterized by hypothesis-driven and low-throughput approaches in the past. However, novel phosphorylation ... -
Rab26 mediates selective targeting of synaptic vesicles to the autophagy pathway
(2015-02-26)In recent years it has been shown that macroautophagy regulates the turnover of postsynaptic receptors and modulates presynaptic neurotransmission. However it is still unclear whether the presynaptic protein turnover is ... -
Reaction mechanism of hOMPD and CaAAD at atomic resolution
(2019-12-12)Decarboxylation reactions are fundamental processes in the chemistry of the animated world. Thus, the evolution of decarboxylases brought up a stunning array of diverse enzymes utilizing a variety of different mechanisms ... -
Reading memory traces in cultured neuronal networks by probabilistic analysis
(2014-02-21)In this thesis, I am studying the enhancement of the collective burst dynamics, burst activation and propagation in hippocampal neuronal networks in-vitro by using optogenetic techniques. Channelrhodopsin-2 transfected ... -
Receptive Field Characterization in MSTd Neurons
(2018-12-14)The dorsal region of the medial superior temporal area (MSTd) in primate extrastriate visual cortex is reported to play a major role in the encoding and perception of optic flow stimuli, i.e. large-scale motion patterns ... -
Receptive field organization of motion computation in the fly: a study of cell types and their variability
(2020-12-02)It is believed that knowing all cell types making up a brain will lead to its understanding. Consequently, current efforts focus on classifying cell types according to their anatomical, genetic and physiological properties. ... -
Recoding of bacteriophage T4 gene 60 mRNA by programmed translational bypassing
(2020-07-28)During synthesis of a topoisomerase subunit encoded by the gene 60 of bacteriophage T4, the ribosome takes off from a certain codon, slides over a 50-nt non-coding segment of mRNA and resumes translation on a specific ... -
Recoding of viral mRNAs by –1 programmed ribosome frameshifting
(2019-06-11)–1 programmed ribosome frameshifting (–1PRF) is commonly used in many viruses and cellular genes. The current study focuses on the –1PRF in two human viruses, human immunodeficiency virus type 1 (HIV-1) and Semliki Forest ... -
Recognition Elements for Elongation Factor P on the Ribosome
(2019-01-25)Translation elongation is a multi-step process orchestrated by elongation factors. Elongation factors G and Tu are required for each round of translation elongation, whereas elongation factor P is only required to assist ...