Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 805-824 of 1164
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Rab26 mediates selective targeting of synaptic vesicles to the autophagy pathway
(2015-02-26)In recent years it has been shown that macroautophagy regulates the turnover of postsynaptic receptors and modulates presynaptic neurotransmission. However it is still unclear whether the presynaptic protein turnover is ... -
Reaction mechanism of hOMPD and CaAAD at atomic resolution
(2019-12-12)Decarboxylation reactions are fundamental processes in the chemistry of the animated world. Thus, the evolution of decarboxylases brought up a stunning array of diverse enzymes utilizing a variety of different mechanisms ... -
Reading memory traces in cultured neuronal networks by probabilistic analysis
(2014-02-21)In this thesis, I am studying the enhancement of the collective burst dynamics, burst activation and propagation in hippocampal neuronal networks in-vitro by using optogenetic techniques. Channelrhodopsin-2 transfected ... -
Receptive Field Characterization in MSTd Neurons
(2018-12-14)The dorsal region of the medial superior temporal area (MSTd) in primate extrastriate visual cortex is reported to play a major role in the encoding and perception of optic flow stimuli, i.e. large-scale motion patterns ... -
Receptive field organization of motion computation in the fly: a study of cell types and their variability
(2020-12-02)It is believed that knowing all cell types making up a brain will lead to its understanding. Consequently, current efforts focus on classifying cell types according to their anatomical, genetic and physiological properties. ... -
Recoding of bacteriophage T4 gene 60 mRNA by programmed translational bypassing
(2020-07-28)During synthesis of a topoisomerase subunit encoded by the gene 60 of bacteriophage T4, the ribosome takes off from a certain codon, slides over a 50-nt non-coding segment of mRNA and resumes translation on a specific ... -
Recoding of viral mRNAs by –1 programmed ribosome frameshifting
(2019-06-11)–1 programmed ribosome frameshifting (–1PRF) is commonly used in many viruses and cellular genes. The current study focuses on the –1PRF in two human viruses, human immunodeficiency virus type 1 (HIV-1) and Semliki Forest ... -
Recognition Elements for Elongation Factor P on the Ribosome
(2019-01-25)Translation elongation is a multi-step process orchestrated by elongation factors. Elongation factors G and Tu are required for each round of translation elongation, whereas elongation factor P is only required to assist ... -
Reconstituted SNARE-mediated fusion: towards a mechanistic understanding
(2012-03-20)A novel and well-characterized model system has been developed and used in order to extract mechanistic insights on the SNARE-mediated fusion process. The reconstitution of SNAREs onto large ... -
Reconstitution of Doa10-mediated ER-associated protein degradation with purified components
(2020-11-09)ER-associated protein degradation (ERAD) is a protein quality control pathway at the ER membrane mediated by membrane-embedded ubiquitin ligase complexes. During ERAD, membrane and luminal proteins are ubiquitinated and ... -
Reconstitution of retrotranslocation by the Hrd1 ubiquitin ligase with purified components
(2020-03-11)In eukaryotic organisms, a large fraction of newly-synthesized proteins are destined for the endomembrane system or for secretion. The entry gate for these proteins is the endoplasmic reticulum (ER). Proteins are imported ... -
Reconstructing the electrical dynamics on the heart
(2022-11-09)The heart is an electro-mechanical system. In 2010 about 4.25 million people died from cardiac arrhythmias. Immediate treatment in case of fibrillation is to shock the heart electrically with high energy to reset the ... -
Reconstruction of Cardiac Wave Dynamics from Mechanical Deformation
(2024-05-24)Cardiac arrhythmias, such as atrial and ventricular fibrillation, are caused by abnormal electrical activity within the heart muscle, leading to irregular contractions and potentially life-threatening situations. Current ... -
Recycling as a mechanism for extracellular matrix remodeling at the synapse
(2021-12-10)In the adult brain, the extracellular matrix (ECM) forms lattices that sheath neurons and synapses. The exceptional longevity of ECM molecules lends these lattices a unique durability, and as such, they are deemed to ... -
Redox imbalance and oxidative stress in Mecp2 deficient neurons
(2016-11-10)Rett syndrome is a neurodevelopmental disorder that primarily occurs in girls with a prevalence of 1:10.000–1:15.000 life births. The main genetic reasons of Rett syndrome are mutations in the methyl-CpG binding protein 2 ... -
Reference frames for planning reach movement in the parietal and premotor cortices
(2016-02-16)Human and nonhuman primates are able to plan and execute goal-directed behavior and flexibly respond to their surrounding stimuli. Their ability to adapt to changes in their environment is a crucial factor for their ... -
Regulation des intrazellulären Transports durch UNC-50 und die GARP-Komplexes in C. elegans
(2010-12-02)Fast synaptic transmission at the neuromuscular junctions (NMJs) in C. elegans is mediated by the neurotransmitter acetylcholine which activates ligand-gated ion channels of the nicotinic ... -
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
Regulation of clade I TGA transcription factors of Arabidopsis thaliana during salicylic acid-mediated defense response
(2020-07-31)TGA1 and TGA4 belong to a family of basic leucine zipper transcription factors. They are important activators of salicylic acid (SA) biosynthesis upon pathogen infection (Sun et al. 2018). Moreover, they interact with a ... -
Regulation of H2B Monoubiquitination Pathway in Breast cancer
(2015-01-23)H2B monoubiquitination (H2Bub1) regulation via CDK9-WAC-RNF20/40 axis has been well illustrated. It is interesting to determine the upstream regulators which dictate the process of monoubiquitination of H2B. On further ...