Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 878-897 of 1164
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Salicylic Acid (SA)-independent processes in Systemic Acquired Resistance (SAR)
(2021-03-25)SAR is an immune response that is established in the systemic leaves after infection of local leaves with biotrophic or hemibiotrophic pathogens. According to the current model, the amino acid-derived metabolite ... -
Saynpatic mechanisms of noise-induced hearing loss
(2024-04-19)Noise-induced hearing loss (NIHL) is a form of acquired hearing impairment, caused by exposure to loud noise, that damages the delicate inner ear structures, possibly including the neural connections between the Inner Hair ... -
Scale-dependent Response of Fluid Turbulence under Variation of the Large-scale Forcing
(2016-02-03)In this work, an experiment to measure the temporal evolution of energy transfer at different scales in a turbulent flow that was subject to a perturbation of the energy injection is described. Two types of experiments ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
Schwann cell differentiation in Charcot-Marie-Tooth disease 1 A (CMT1A)
(2019-04-11)Charcot–Marie–Tooth disease is the most common inherited neuropathy and a duplication of the peripheral myelin protein 22 gene (PMP22) causes the most frequent sub-form Charcot–Marie–Tooth 1A (CMT1A). In contrary to the ... -
Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling
(2014-07-31)The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as ... -
Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach
(2013-01-04)The members of the Sec1p/Munc18 (SM) family of proteins are indispensible regulatory elements that act at the post-docking step prior to fusion; they exert their function mainly through their interaction to the Qa-SNAREs ... -
Self-association of adenovirus 5 E1B-55 kDa as well as p53 is essential for their mutual interaction
(2009-12-15)P53 is at the center of the control systems that mediate the response to DNA damage, leading to cell cycle arrest or apoptosis. Virus infection can cause a DNA damage response through virus ... -
Self-Organization and Mechanics of Minimal Actin Cortices attached to artificial Bilayers
(2018-10-23)One of the most versatile used protein structure in nature are actin filaments. They form contractile structures, like muscle fibrils, as well as complex network structures like the cellular cortex. The actin cortex is ... -
Self-Organization in Catalytically Active Mixtures
(2023-08-14)Living systems are intrinsically out of equilibrium, which makes their physical description challenging. This has led to the emergence, over the past thirty years, of a new field of physics, active matter, which studies ... -
Self-organization of microtubules for biomimetic structures
(2021-07-05)Biological polymers that build up the eukaryotic cytoskeleton exhibit a rich dynamical behaviour that aid a multitude of cellular processes. Microtubules, together with their associated motor proteins in the cell are ... -
Sensitivity Enhanced NMR
(2014-04-16)The topic of this thesis is the investigation of how sensitivity enhanced Nuclear Magnetic Resonance (NMR) spectra of biological systems could be obtained by dynamic nuclear polarization (DNP) under conditions close to ... -
Shear flow experiments: Characterizing the onset of turbulence as a phase transition
(2014-04-07)In this cumulative thesis the onset of turbulence in shear flows with a linearly stable laminar flow is investigated experimentally. The experiments are performed in a pipe and a Taylor-Couette setup, both with large system ... -
Signal transduction by the essential nucleotide second messenger cyclic di-AMP in Bacillus subtilis
(2021-01-15)Bacillus subtilis, as a soil inhabitant, has to adapt to rapidly changing osmotic conditions. The response to these osmotic changes represents one of the most critical issues in the lifecyle of bacteria, and the tight ... -
Signalling from Endosomes in Neurodevelopment and Neurodegenerative Disorders
(2021-11-15)The nervous system is developed under the regulation of growth and guidance cues. This process is highly dynamic and tightly regulated by the composition, concentration and timely presence of different signalling molecules. ... -
Signalling of hematopoietic growth factors in mammalian neural cells
(2007-07-31)This dissertation examines signalling of hematopoietic growth factors in hippocampal neurons and cortical astrocytes. The activity patterns of Akt, ERK1/2 and Stat3 after treatment with ... -
Simulation of fronto-parietal neural population activity to probe dimensionality reduction methods.
(2022-09-20)Recent developments of optical and electrophysiological recording tools allow the detailed capture of large neuronal populations. Findings show that their activity is constrained to a low-dimensional manifold within the ... -
Single Molecule Cryo-Fluorescence Microscopy
(2016-11-07)This work presents a newly developed cryo-fluorescence microscopy system and several of its applications. The thesis is divided into three parts. Part I introduces the design of the cryo-fluorescence microscope, and ... -
Single Molecule Fluorescence Spectroscopy and Imaging: Advanced Methods and Applications in Life Sciences
(2021-06-03)The visualization of biological structures down to the molecular length scale has been recently made possible by the development of super-resolution fluorescence microscopy. These techniques now routinely resolve biological ... -
Single molecule fluorescence spectroscopy of the structure and dynamics of the spliceosome
(2013-11-05)Binding reactions can be ideally investigated by Dual-Color Fluorescence Cross-Correlation Spectroscopy (FCCS). Here, this method is used to study the recruitment and dissociation of proteins to and from the spliceosome. ...