Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1004-1023 of 1169
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Targeted secretion and remodelling of pectin in response to pathogen infection
(2020-04-02)Plant cell walls are a complex mix of three major classes of polysaccharides; cellulose, hemicellulose and pectin together with a minor amount of proteins, and they surround every plant cell. Besides serving as a structural ... -
Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
(2022-02-24)The synapse is a specialized nanostructure that connects two neurons where the ionic composition in each of its nano compartments is the driving process for synaptic transmission. Synaptic transmission relies on the ... -
Targeting microglial CSF1R in health and disease
(2021-09-03)The main effector functions of microglia are immune, synaptic network refinement, brain insult reaction, and neurogenesis regulation. This cumulative doctoral thesis focuses on the relevance of the colony-stimulating factor ... -
Temporal information processing and memory guided behaviors with recurrent neural networks
(2015-02-25)The ability to quantify temporal information on the scale of hundreds of milliseconds is critical towards the processing of complex sensory and motor patterns. However, the nature of neural mechanisms for temporal information ... -
Thalamocortical Innervation of GABAergic Interneurons in Mouse Primary Vibrissal Somatosensory Cortex
(2020-11-26)Interneurons utilizing gamma-aminobutyric acid (GABA) as primary neurotransmitter are thought to play a key role in neocortical processing. Their striking diversity has been in focus of numerous studies for decades. However, ... -
The 5XFAD mouse model: a tool for genetic modulation of Alzheime's disease pathology
(2012-01-25)AD mouse models contributed widely to our understanding of the pathophysiology of AD and represent invaluable tools in testing potential therapeutic interventions. In the present study, ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
The Advantages Of Paramagnetic NMR
(2013-11-28)There are three distinct effects in nuclear magnetic resonance spectroscopy (NMR) that differ between paramagnetic and diamagnetic molecules in isotropic solution. These are residual dipolar coupling (RDC), pseudocontact ... -
The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance
(2019-07-11)The VapA-VapB-VipC trimeric complex is part of an epigenetic developmental control pathway of A. nidulans. VeA-interacting protein (VipC) and VipC-associated protein B (VapB) are methyltransferases, and VapA is a zinc-finger ... -
The Cellular Function of USP22 and its Role in Tissue Maintenance and Tumor Formation
(2018-02-12)Colorectal cancer (CRC) is the most frequent malignancy of the gastrointestinal tract and therefore reflects a global health issue. Despite improved detection and treatment options the high mortality and morbidity rates ... -
The client spectrum of Get3, an evolutionarily conserved chaperone of membrane proteins
(2020-03-12)Tail-anchored proteins constitute a physiologically important class of membrane proteins. Due to their topology, they are targeted post-translationally to membranes. Although Get3 is responsible for the membrane targeting ... -
The Coalescent in Boundary-Limited Range Expansions
(2014-10-14)Habitat ranges of most species shift over time, for instance due to climate change, human intervention, or adaptation. These demographic changes often have drastic effects on the genetic composition of the population, ... -
The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's disease
(2012-09-07)A heterogeneou s mixture of amyloid beta (Aβ) isoforms exists in the brains of Alzheimer's disease (AD) patients. Despite decades of research, relatively little is known about the precise contribution of these variousAβ ... -
The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
The COP9 signalosome of Aspergillus nidulans
(2009-06-04)The COP9 signalosome (CSN) is a conserved eukaryotic multiprotein complex, playing a multifaceted role in the regulation of protein degradation by the ubiquitin system. The primary function ... -
The Dynamic Organization of Proteins in the Synaptic Bouton
(2022-09-12)Protein availability is crucial for maintaining cellular processes. In synapses, the identities and functions of proteins involved in neurotransmission are well known. Their spatial distribution, copy numbers, and lifetimes ... -
The Effect of Finite Temperature on the Jamming Transition
(2016-05-30)We study the effect of finite temperatures on spring networks obtained from amorphous, jammed packings of repulsive spheres. By means of a Monte Carlo Metropolis scheme, we analyse this two-dimensional model of an amorphous ... -
The EPO/EPOR system in the brain: Search for mechanisms of action
(2014-04-17)Erythropoietin (EPO) and its receptor (EPOR) are known to be essential for erythropoiesis. However, the EPO/EPOR system turned out to have additional important functions in non-hematopoietic tissue. The brain is one of the ... -
The evolution of hydrophobic barriers among land plants
(2023-08-03)The terrestrialization of plants required major physiological and metabolic adaptations, including the capacity to deposit extracellular hydrophobic barriers that shield plant surfaces against various abiotic and biotic ... -
The Evolutionary Establishment of Apomixis in Hybrids of the Ranunculus auricomus Complex: Developmental and Cytogenetic Studies
(2020-06-16)In plant evolution, polyploidization and hybridization are important forces that both effectively contribute to developmental alterations. Asexual seed formation, known as apomixis, is mainly found in polyploid and/ or ...