Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1215-1218 of 1218
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XDazl function in RNA metabolism in Xenopus laevis
(2015-11-25)Germ cell specification in Xenopus laevis depends on the inheritance of maternal determinants from the oocyte in form of mRNAs and proteins. At the onset of zygotic transcription, maternal mRNAs are subjected to miR-mediated ... -
Yeast models to study mutations in SURF1 and MPV17 involved in human mitochondrial disorders
(2011-12-06)Mitochondrial diseases are fatal disorders mainly affecting highly energy dependent tissues such as brain, heart, liver and muscle. These severe disorders can be caused by mutations affecting mitochondrial- or nuclear-encoded ... -
Zebrafish as a Model for Hereditary Spastic Paraplegia
(2023-06-28)To investigate the mechanism of pathogenesis of the rare and complex neurodegenerative disorder Hereditary Spastic Paraplegia (HSP), which causes lower limb motility defects, it is crucial to establish simple and tractable ... -
α-synuclein disrupts neuron network rhythmic activity when overexpressed in cultured neurons
(2021-03-09)Synucleinopathies are associated with a generalized slowing of the brain’s rhythmic activity, which co-occurs with dementia and has been connected with increased levels of α synuclein in both patients and test animals. In ...