Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 115-134 of 1263
-
Bioinformatics analysis of multi-omics data elucidates the primary function of Oct4 in gene regulation and pluripotency maintenance
(2022-03-14)The transcription factor (TF) Oct4 is essential for maintaining pluripotency in vitro as well as in vivo. The crucial function of Oct4 in control of pluripotency has been extensively studied during reprogramming of somatic ... -
Bioinformatics analysis of multi-omics data elucidates U2 snRNP function in transcription
(2021-08-16)Transcription by RNA polymerase II (Pol II) is an important step in cell function and regulation. Pol II transcription has been shown to be coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly ... -
Biophysical and Crystallographic Characterization of Spliceosomal DExD/H-box ATPases
(2020-04-23)DEAH-box ATPases play a vital role in the activation, catalytic and disassembly steps of the spliceosome. They are key for the orchestration of conformational and compositional rearrangements during the splicing cycle. It ... -
Biophysical and molecular mechanisms of mean and variance adaptation in the Drosophila ear
(2023-05-16)Adaptation is an important mechanism found across sensory systems and species. This important ability of sensory systems expands our range of perception. Giving us the ability to perceive a quiet whisper as well as a loud ... -
Biophysical modeling of information processing in the <i>Drosophila</i> olfactory system
(2014-04-24)Fruit flies (Drosophila melanogaster) rely on their olfactory system to process environmental information. Although extensive studies have helped neurobiologists to understand the basic molecular and cellular mechanisms ... -
Blood Platelet Behavior on Structured Substrates
(2015-11-02)Blood clotting is the immediate answer of the body to injuries. In this process, blood platelets adhere to the injured site, spread over the wound and form a blood clot, in which single platelets are connected by fibrin ... -
Bone Morphogenetic Protein signaling in the planarian flatworm Schmidtea mediterranea – evolutionary, cellular, and spatial patterns
(2025-03-13)In early development, morphogen gradients orchestrate the establishment of body axes. Perturbations of such a fundamental process are often damaging to embryonal development, making it difficult to study the role of body ... -
Brain-wide connectivity of molecularly defined GABAergic neurons in mouse barrel cortex visualized with optimized rabies virus tracing
(2020-03-16)Cortical GABAergic neurons are indispensable in controlling the activity of cortical networks. Parvalbu- min (PV), somatostatin (SST) and vasoactive intestinal polypeptide (VIP) expressing neurons are three main classes ... -
Branching control mechanisms in the model tree Populus: analyzing the role of strigolactones and BRANCHED1
(2016-05-13)Plants exhibit a large degree of phenotypic plasticity. Modifications of their genetically pre-defined body plan allow them to flexibly react to a wide range of environmental conditions. This includes changes in plant ... -
CarotPhyte: Exploring the evolutionary roots for the biosynthesis of apocarotenoids and their role as signals in plastid-mediated stress response in streptophyte algae
(2024-10-18)Plant terrestrialization came with enormous multidimensional consequences that shaped planet earth. This terraforming event that occurred about 550 MYA goes back to a single progenitor. Elucidating important facilitators ... -
Catalysis at the Interface- Elucidation of the Activation Process and Coupling of Catalysis and Compartmentalization of the Peripheral Membrane Protein Pyruvate Oxidase from Escherichia coli
(2014-02-06)The thiamine- and flavin-dependent peripheral membrane protein pyruvate oxidase from E. coli (EcPOX) catalyzes the oxidative decarboxylation of the central metabolite pyruvate to CO2 and acetate with a concomitant electron ... -
Cell and Receptor Tropism of γ2-Herpesviruses
(2021-02-25)Kaposi’s sarcoma-associated herpesvirus (KSHV), the only rhadino- or γ2-herpesvirus of humans, is associated with Kaposi’s sarcoma (KS) and two B cell proliferative malignancies, primary effusion lymphoma (PEL) and a ... -
Cell death signaling in the Arabidopsis chitin receptor mutant cerk1-4
(2024-11-07)Plant surface immunity is mediated by pattern recognition receptors (PRRs) that recognize con-served molecules derived from microorganisms. In Arabidopsis, CERK1 is the main component of the receptor complex that binds ... -
Cellular dynamics and stable chaos in balanced networks
(2016-01-22)A prudent approach to understanding the function of the cerebral cortex begins with understanding the repertoire of its dynamics. In this thesis, I study how interactions between single neuron properties, synaptic coupling, ... -
Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans
(2013-04-09)Parkinson’s disease (PD) is the second most common neurodegenerative disease in industrialized countries. However, the molecular mechanisms leading to neuronal death in PD still remain unclear. About 5-10% of PD patients ... -
Cellular locomotion and adhesion in the context of different substrate properties
(2017-01-16)This work comprises three different projects dealing with the interplay of cellular locomotion and adhesion to establish a better understanding of the response of cells to their environment. In the first part of this thesis ... -
Cellular mechanisms of odor detection in the olfactory system of the red flour beetle Tribolium castaneum
(2015-10-26)Olfaction, the detection of odors is pivotal for insects, since it leads them to food sources or mating partners and triggers important behaviors. For the detection of pheromones, CD36-related sensory neuron membrane ... -
Cellular stress induces RIS dependent sleep and ALA dependent sedation via EGF receptor signaling in Caenorhabditis elegans
(2019-07-15)Why do we sleep? This question is still unsolved, although sleep is such a fundamental behavioral state in all organism with a nervous system. Several physiological mechanisms, like memory consolidation, metabolic waste ... -
Central sound encoding in the inferior colliculus of mouse models for human auditory synaptopathy and neuropathy
(2018-12-20)Auditory neuropathy and auditory synaptopathy are hearing disorders with normal outer hair cell function and cochlear amplification, but an impairment in the function of inner hair cells, their ribbon synapses, or in the ... -
CFM: Confinement Force Microscopy-a dynamic, precise and stable microconfiner for traction force microscopy to study confined cell behaviour
(2024-01-11)Physical properties of the 3D microenvironment and the residing tissue affect cell behavior and function. 3D environment represents major physical obstacles for cell migration, such as spatial confinement, which could ...