Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1175-1194 of 1263
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The Role of the Hedgehog Receptor Patched in LysM+ Cells in Mice
(2013-12-04)Cancer development is frequently linked to signaling pathways that are required for normal embryonic patterning. One of the pathways important in patterning and growth of the embryo is the Hedgehog (Hh) signaling cascade. ... -
The role of the lung in shaping CNS autoimmunity
(2019-10-24)The lung was recently identified as a central site of T cell reprogramming in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). While residing in the pulmonary tissue, central ... -
The role of the mammalian GET pathway in the mouse liver
(2016-11-29)The correct insertion of membrane proteins is essential for the normal functioning of a eukaryotic cell, and different classes of membrane proteins employ different mechanisms of insertion into their target membrane. One ... -
The role of the mir-310s in Hedgehog Signaling regulation under dietary stress in the Drosophila ovary
(2016-02-03)Perturbations in nutrition and energy homeostasis can have deleterious effects on human health. Therefore, mechanisms controlling metabolic balance and initiating fast response to changing dietary conditions are essential. ... -
The role of the novel endosomal protein Rush hour (CG14782) in endosomal trafficking in Drosophila melanogaster
(2011-03-29)Endocytosis regulates multiple cellular processes, including the protein composition of the plasma membrane, intercellular signaling and cell polarity. Cell polarity is defined by asymmetric ... -
The Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel in Sharp Wave Ripples, Place Cells, and Spatial Memory
(2024-02-09)Previous research in our lab found impaired long-term potentiation (LTP) of CA3-CA1 synapses, a fundamental process for learning and memory, in transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice. The TRPV1 ... -
The role of TRIP13 in DNA damage repair
(2023-08-10)Double-strand breaks, the most toxic DNA lesions, can be repaired via homologous recombination or non-homologous end joining (NHEJ). Using the right pathway at the right time is crucial to maintain genome integrity. ... -
The role of tryptophan-rich basic protein (WRB) in inner hair cell synaptic transmission and hearing
(2014-06-06)The tryptophan-rich basic protein (WRB) has recently been proposed to act as the receptor of tail-anchored (TA) proteins. Together with the cytosolic protein TRC40 it presumably builds the main components of the posttranslational ... -
The role of two families of lipid droplet-associated proteins
(2025-09-16)Lipid droplets (LDs) are unique subcellular compartments that are specialized for lipid storage. In recent years, the number of identified and characterized LD-associated proteins has been greatly increased, which, on the ... -
The role of UNC-108/RAB-2 in neuronal dense core vesicle maturation in C. elegans
(2010-05-19)Small GTPases of the Rab family are involved in vesicular transport between different intracellular compartments. C. elegans mutant alleles of unc-108/rab-2 have been isolated based on their ... -
The role of α-neurexins in Ca<sup>2+</sup>-dependent synaptic transmission and plasticity
(2006-05-18)This project investigated novel aspects of the function of α-neurexins in neurotransmission and synaptic plasticity. Whole-cell patch-clamp studies on heterologous cells showed that neurexin ... -
The roles of GTPases in biogenesis of the large ribosomal subunit
(2025-09-22)Ribosomes are ribonucleoprotein complexes responsible for protein synthesis, and their biogenesis is a complex, highly orchestrated process requiring a significant amount of energy and the coordinated action of all three ... -
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
(2020-05-29)RNA helicases are a highly conserved family of proteins that act as RNA-dependent NTPases. These proteins contain a conserved helicase core consisting of two RecA-like domains that are responsible for unwinding or annealing ... -
The Saccharomyces cerevisiae HtrA orthologue, Ynm3, is a chaperone-protease that aids survival under heat stress
(2008-11-13)Ynm3 is the only budding yeast protein possessing a combination of a serine protease and PDZ domains, a defining feature of the widely conserved HtrA (high temperature requirement A) protein ... -
The secreted serine protease xHtrA1 is a positive feedback regulator of long-range FGF signaling.
(2007-09-13)Fibroblast growth factors (FGFs) are important signaling molecules, whose activities need to be tightly controlled. We have recently identified the Xenopus homolog of HtrA1 (xHtrA1) in a ... -
The somatosensory system: Exploration of digit-area somatotopy and feature-based attention
(2013-12-19)Even though the skin is by far the largest sensory organ that we humans possess and immensely important for coping with everyday life, the somatosensory system has been studied far less than the visual or auditory system. ... -
The STRIPAK complex and its role in fruiting-body development of the filamentous fungus Sordaria macrospora
(2015-09-23)The mammalian Striatin-interacting phosphatase and kinase (STRIPAK) complex consist of many proteins, among them Striatin as scaffold, the putative kinase activator monopolar spindle-one-binder 3 (MOB3), serine/threonine ... -
The Synaptic RNAome - identification, interactions and intercellular transfer
(2021-03-19)Synaptic plasticity is how neurons adapt to new stimuli and necessitates changes in synaptic weight. For these changes to be durable, local translation in neurites, and at pre- and post-synapses is required. Current methods ... -
The Tip60 chromatin remodeling complex is required for maintenance and polarity of Drosophila neural stem cells
(2017-10-10)Stem cells are self-renewing cells which produce differentiating offspring during development and tissue homeostasis. Appropriate regulation of stem cell division is highly important to ensure maintenance of the stem cell ... -
The transmembrane receptors Otk and Otk2 function redundantly in Drosophila Wnt signal transduction
(2013-06-11)Canonical and non-canonical Wnt signaling pathways have in common Frizzled (Fz) as the core Wnt receptor element. Recent findings implicate that not only the choice of Wnt ligands, but also the presence of additional ...