Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title

Theoretical analysis of membrane properties underlying action potential phase-locking in noise-driven cells

Öz, Pýnar (2011-12-09)

How does the brain work? This very broad and yet, very crucial and interesting question appealed scientists from various disciplines to itself. The fact that the operation of a system of ...

Theoretical Studies of the Dynamics of Action Potential Initiation and its Role in Neuronal Encoding

Wei, Wei (2011-08-08)

In this thesis analytically solvable neuron models are constructed to study the inﬂuence of the initiation speed and location of AP (action potential) generation on the dynamical response ...

Therapeutic approaches for two distinct CNS pathologies

Stumpf, Sina Kristin (2020-06-19)

This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ...

Thermosensory Transduction Mechanisms in Drosophila melanogaster

Kossen, Robert (2019-10-18)

Ambient temperature has an profound effect in the physiology of all animals and accurate evaluation of both external and internal temperatures is therefore an essential factor for fitness and survival. To this end, animals ...

Three-dimensional electron microscopy of structurally heterogeneous biological macromolecules

Hauer, Florian (2009-10-28)

Biological macromolecules exert their biological functions in a dynamic network of large assemblies. The biological function of these macromolecular assemblies is closely related to dynamic ...

Time- and gender- dependent differences in neuronal behaviors in culture

Sertel, Sinem Meleknur (2020-05-29)

Isolating cells from a living organism and growing them in a Petri dish allowed scientists to study the physiology and biochemistry of healthy and diseased cells. Today we have cell cultures from almost any tissue type, ...

Topological Optimization in Network Dynamical Systems

Van Bussel, Frank (2011-04-05)

In this thesis we look at results concerning two separate topics.The first topic belongs to the general problem of reconstruction of interaction networks using only per-site information. ...

Touch comes of Age - Maturational Plasticity in Somatosensory Mechanosensation

Michel, Niklas (2020-08-06)

Somatosensory mechanosensation remains to be the least understood sensory system in vertebrates. It requires the activation of specialised neurons which innervate the skin and internal organs. A subset of these dorsal root ...

Touching upon regulators of Piezo2 in mouse somatosensation

Narayanan, Pratibha (2018-03-15)

ABSTRACT Mechanosensation is an integral property of sensory systems like audition and somatosensation. The molecular determinants of mechanotransduction in mammals are only beginning to be understood. In 2010, Piezo2, a ...

Towards Optical Cochlear Implants: Behavioral and Physiological Responses to Optogenetic Activation of the Auditory Nerve

Dieter, Alexander (2019-11-15)

Cochlear implants (CIs) constitute the interface between the sound-deprived brain of patients suffering from sensorineural hearing loss and the auditory scene surrounding them. By electrically stimulating the auditory nerve ...

Towards population coding principles in the primate premotor and parietal grasping network

Michaels, Jonathan A. (2017-01-03)

As humans, the only way for us to interact with the world around us is by utilizing our highly trained motor system. Therefore, understanding how the brain generates movement is essential to understanding all aspects of ...

Towards Uncovering the Role of Pre-fibrillar Oligomers of á-Synuclein in the Pathogenesis of Parkinson's Disease

Gajula Balija, Madhu Babu (2010-08-06)

Parkinson s disease (PD) is a progressive neuropathological disorder that is characterized by the presence of intra-cytoplasmic inclusions called Lewy Bodies (LBs). LBs represent insoluble ...

Tracing evolutionary patterns across the green lineage with respect to protein families and pathways in response to stress

Dhabalia Ashok, Amra (2024-08-22)

The evolutionary history of Chloroplastida is unique, as it includes the emergence of those organisms that make up the macroscopic flora on land: the land plants (embryophytes). The land plants arose from a singular ...

Tracking Assembly Kinetics of Intermediate Filaments

Saldanha, Oliva (2017-04-13)

Vimentin is an intermediate filament (IF) protein in eukaryotic cells and together with other IFs, actin filament and microtubules plays an instrumental role in providing stability and mechanical properties to the cell. ...

Transcription factor Pax6 controls structure and function of the centrosome in cortical progenitors

Tylkowski, Marco Andreas (2013-07-15)

The mammalian neocortex is a highly complex structure containing more than 100 billions neurons and ten times more glia cells that are generated during development by progenitor cells located at the apical surface of the ...

Transcriptional control of the establishment of neocortical projections in the mammalian telencephalon

Srivatsa, Swathi (2015-01-12)

Neuronal connections in the neocortex that relay and integrate informationform the basis of our higher cognitive abilities. Transcription factors play animportant role in controlling the trajectory of neuronal projections. ...

Transduction in Olfactory Receptor Neurons of Xenopus laevis Larvae: Pharmacological Blockage with FM1-43 and Endocannabinoid Modulation

Breunig, Esther (2010-09-29)

The sense of smell is critical for finding food and mediating emotional and social responses. A dysfunction of this sense is often associated with diseases. In the last two decades much ...