Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1215-1231 of 1231
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Viscoelastic properties of epithelial cells: 3D structures and composite elements
(2025-03-14)Epithelial cells form complex, polarized layers in the body to cover organs and cavities. While the mechanical properties of single cells and 2D monolayers have been extensively studied, recent research suggests that 3D ... -
Vision, cortical maps and neuronal plasticity in Bassoon and PSD-95 mutant mice.
(2014-03-21)Bassoon mutant mice (Bsn-/-) display a striking loss of synaptic ribbons in photoreceptor terminals, which impairs signal transduction through the retina (Altrock et al., 2003; Specht et al., 2007). Therefore we assessed ... -
Visual and Auditory Perceptual Decision-Making in The Human Brain as Invesitgated by fMRI and Lesion Studies
(2017-07-27)Perceptual decision-making refers to the act of choosing one option from a set of alternatives based on the available sensory information. In this manuscript, we used model-based functional magnetic resonance imaging and ... -
Visual information processing, welfare, and cognition in the rhesus macaque
(2017-10-20)Visual information processing, welfare, and cognition in the rhesus macaque - Chapter one deals with motion and disparity in macaque monkeys' area MST and their functional independence. Chapter two relates with the advantages ... -
Visualization of synaptic vesicle protein recycling during exo-endocytosis at individual hippocampal boutons
(2006-02-20)Upon exocytosis synaptic vesicle proteins are released into the plasma membrane and must be retrieved by compensatory endocytosis. When overexpressing GFP-labeled versions of the vesicle ... -
Vitamin B6 metabolism and underground metabolic routes in the Gram-positive bacterium Bacillus subtilis
(2021-07-16)Genome-reduced bacteria give the opportunity to study essential gene functions but also give the starting point for biotechnological production pathways. The MiniBacillus project aims to produce a genome reduced Bacillus ... -
Vitamin B6 Production in Bacillus subtilis
(2018-01-23)Fermentative production of valuable goods is an economically competitive and ecologically sustainable alternative to chemical synthesis. Several previous studies have been dedicated to the establishment of vitamin B6 ... -
Voltage-gating and assembly of split Kv10.1 channels
(2016-07-04)Voltage-gated ion channels allow ions to pass cell membrane upon changes of transmembrane electrical potential. Conformational changes in the voltage-sensing domain of the channel (VSD) are assumed to be transmitted to the ... -
Weakly Selective Training induces Specialization within Populations of Sensory Neurons
(2016-12-16)Many neurons in sensory pathways respond selectively to a narrow class of stimuli such as faces or specific communication calls. At the same time neural processing is robust to a large degree of natural variablity ... -
What an Insect Brain Can Tell Us: The Impact of Intrinsic and Extrinsic Factors on Long-Term Memory in Drosophila melanogaster Larvae
(2025-01-10)Learned associations can be consolidated into long-lasting memory traces, influenced by the relevance and abundance of information, as well as internal states of the animal. In adult Drosophila two distinct forms of ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ... -
Wif1 Inhibits the Growth of Basal Cell Carcinoma
(2015-12-22)Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin cancers and is the most commonly diagnosed cancer in fair-skinned individuals. In the majority of BCC the tumor suppressor gene patched1 (PTCH) is ... -
Wiring and information processing in the olfactory bulb of larval Xenopus laevis
(2020-02-04)Olfactory systems of vertebrates have adapted to the various challenges of their environments on both the level of odorant receptors and neuronal wiring. Amphibians like the African clawed frog Xenopus laevis offer a ... -
XDazl function in RNA metabolism in Xenopus laevis
(2015-11-25)Germ cell specification in Xenopus laevis depends on the inheritance of maternal determinants from the oocyte in form of mRNAs and proteins. At the onset of zygotic transcription, maternal mRNAs are subjected to miR-mediated ... -
Yeast models to study mutations in SURF1 and MPV17 involved in human mitochondrial disorders
(2011-12-06)Mitochondrial diseases are fatal disorders mainly affecting highly energy dependent tissues such as brain, heart, liver and muscle. These severe disorders can be caused by mutations affecting mitochondrial- or nuclear-encoded ... -
Zebrafish as a Model for Hereditary Spastic Paraplegia
(2023-06-28)To investigate the mechanism of pathogenesis of the rare and complex neurodegenerative disorder Hereditary Spastic Paraplegia (HSP), which causes lower limb motility defects, it is crucial to establish simple and tractable ... -
α-synuclein disrupts neuron network rhythmic activity when overexpressed in cultured neurons
(2021-03-09)Synucleinopathies are associated with a generalized slowing of the brain’s rhythmic activity, which co-occurs with dementia and has been connected with increased levels of α synuclein in both patients and test animals. In ...