Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1218-1237 of 1269
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Towards population coding principles in the primate premotor and parietal grasping network
(2017-01-03)As humans, the only way for us to interact with the world around us is by utilizing our highly trained motor system. Therefore, understanding how the brain generates movement is essential to understanding all aspects of ... -
Towards Uncovering the Role of Pre-fibrillar Oligomers of á-Synuclein in the Pathogenesis of Parkinson's Disease
(2010-08-06)Parkinson s disease (PD) is a progressive neuropathological disorder that is characterized by the presence of intra-cytoplasmic inclusions called Lewy Bodies (LBs). LBs represent insoluble ... -
Tracing evolutionary patterns across the green lineage with respect to protein families and pathways in response to stress
(2024-08-22)The evolutionary history of Chloroplastida is unique, as it includes the emergence of those organisms that make up the macroscopic flora on land: the land plants (embryophytes). The land plants arose from a singular ... -
Tracking Assembly Kinetics of Intermediate Filaments
(2017-04-13)Vimentin is an intermediate filament (IF) protein in eukaryotic cells and together with other IFs, actin filament and microtubules plays an instrumental role in providing stability and mechanical properties to the cell. ... -
Transaldolase from Thermoplasma acidophilum: new reactivities and applications in biocatalysi
(2025-06-27)In this PhD thesis, the enzyme transaldolase from the thermophilic organism Thermoplasma acidophilum (TacTAL) was studied from two related perspectives: its reactivity toward 5-carbon phosphosugars and its potential ... -
Transcription factor Pax6 controls structure and function of the centrosome in cortical progenitors
(2013-07-15)The mammalian neocortex is a highly complex structure containing more than 100 billions neurons and ten times more glia cells that are generated during development by progenitor cells located at the apical surface of the ... -
Transcriptional control of the establishment of neocortical projections in the mammalian telencephalon
(2015-01-12)Neuronal connections in the neocortex that relay and integrate informationform the basis of our higher cognitive abilities. Transcription factors play animportant role in controlling the trajectory of neuronal projections. ... -
Transcriptomic Mechanisms in Post-mitotic and Excitable Cells in Inter-Organ Communication
(2025-12-04)The human body functions as an integrated network where organs communicate through complex molecular signals rather than as isolated systems. This inter-organ communication occurs through various mediators including proteins, ... -
Transduction in Olfactory Receptor Neurons of Xenopus laevis Larvae: Pharmacological Blockage with FM1-43 and Endocannabinoid Modulation
(2010-09-29)The sense of smell is critical for finding food and mediating emotional and social responses. A dysfunction of this sense is often associated with diseases. In the last two decades much ... -
Transgenic fungal expression and characterization of a fluorescently-tagged variant of the Verticillium effector protein TRADEVd, and functional elucidation of its Fusarium homolog TRADEFo, and of another Verticillium effector candidate, LSCE1Vd
(2025-09-11)Vascular wilt fungi have an arsenal of secreted effector proteins, which manipulate the host physiology and immune system for their successful colonization. Among these effectors, Verticillium TRADEVd was previously ... -
Translation Termination in Human Mitochondria: The Role of mtRF1 and mtRF1a
(2022-12-09)Translation termination is the last step of ribosomal protein synthesis. Dedicated translation factors are imported into mitochondria to convert the information stored in the retained mitochondrial DNA (mtDNA) and to ... -
Transmembrane Signalling: Structural and Functional Studies on Histidine Kinase CitA
(2015-12-03)Bacteria utilise two component systems (TCS) consisting of a homodimeric receptor histidine kinase (HK) and a response regulator (RR) as a prevalent mechanism of stimulus perception and signal transduction. TCSs are key ... -
Transport mechanisms of the putative vesicular nucleotide transporter VNUT
(2024-12-13)The vesicular nucleotide transporter VNUT (SLC17A9) is thought to refill recycled synaptic vesicles and other secretory vesicles with adenosine triphosphate (ATP) for chemical signal transmission. ATP translocation by VNUT ... -
Transport of Tail-anchored Proteins to the Inner Nuclear Membrane
(2017-04-13)In contrast to the well-studied process of nucleocytoplasmic transport of soluble macromolecules, little is known about the targeting of integral membrane proteins to the inner nuclear membrane (INM), therefore the targeting ... -
Turbulence and pattern formation in continuum models for active matter
(2020-02-13)Living and nonliving active matter, ranging from flocks of birds to active colloids, exhibit a fascinating range of physical phenomena such as order-disorder transitions and density waves in flocking phases, chaotic states ... -
Turbulence Measurements in Flows with Particles
(2023-01-31)Despite the ubiquity of turbulent flows in nature, a general solution to the governing equations of motion remain elusive. These equations are nonlinear and nonlocal, and they describe a chaotic system with multi-scale ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
Uncovering the mode of action of small molecule inhibitors against the RNA polymerase of SARS-CoV-2
(2025-03-07)Severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) is the causative agent of coronavirus disease 2019 (COVID-19). The pandemic has claimed more than 7 million lives since its outbreak at the beginning of 2020, ...