Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1219-1238 of 1263
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Transcriptomic Mechanisms in Post-mitotic and Excitable Cells in Inter-Organ Communication
(2025-12-04)The human body functions as an integrated network where organs communicate through complex molecular signals rather than as isolated systems. This inter-organ communication occurs through various mediators including proteins, ... -
Transduction in Olfactory Receptor Neurons of Xenopus laevis Larvae: Pharmacological Blockage with FM1-43 and Endocannabinoid Modulation
(2010-09-29)The sense of smell is critical for finding food and mediating emotional and social responses. A dysfunction of this sense is often associated with diseases. In the last two decades much ... -
Transgenic fungal expression and characterization of a fluorescently-tagged variant of the Verticillium effector protein TRADEVd, and functional elucidation of its Fusarium homolog TRADEFo, and of another Verticillium effector candidate, LSCE1Vd
(2025-09-11)Vascular wilt fungi have an arsenal of secreted effector proteins, which manipulate the host physiology and immune system for their successful colonization. Among these effectors, Verticillium TRADEVd was previously ... -
Translation Termination in Human Mitochondria: The Role of mtRF1 and mtRF1a
(2022-12-09)Translation termination is the last step of ribosomal protein synthesis. Dedicated translation factors are imported into mitochondria to convert the information stored in the retained mitochondrial DNA (mtDNA) and to ... -
Transmembrane Signalling: Structural and Functional Studies on Histidine Kinase CitA
(2015-12-03)Bacteria utilise two component systems (TCS) consisting of a homodimeric receptor histidine kinase (HK) and a response regulator (RR) as a prevalent mechanism of stimulus perception and signal transduction. TCSs are key ... -
Transport mechanisms of the putative vesicular nucleotide transporter VNUT
(2024-12-13)The vesicular nucleotide transporter VNUT (SLC17A9) is thought to refill recycled synaptic vesicles and other secretory vesicles with adenosine triphosphate (ATP) for chemical signal transmission. ATP translocation by VNUT ... -
Transport of Tail-anchored Proteins to the Inner Nuclear Membrane
(2017-04-13)In contrast to the well-studied process of nucleocytoplasmic transport of soluble macromolecules, little is known about the targeting of integral membrane proteins to the inner nuclear membrane (INM), therefore the targeting ... -
Turbulence and pattern formation in continuum models for active matter
(2020-02-13)Living and nonliving active matter, ranging from flocks of birds to active colloids, exhibit a fascinating range of physical phenomena such as order-disorder transitions and density waves in flocking phases, chaotic states ... -
Turbulence Measurements in Flows with Particles
(2023-01-31)Despite the ubiquity of turbulent flows in nature, a general solution to the governing equations of motion remain elusive. These equations are nonlinear and nonlocal, and they describe a chaotic system with multi-scale ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
Uncovering the mode of action of small molecule inhibitors against the RNA polymerase of SARS-CoV-2
(2025-03-07)Severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) is the causative agent of coronavirus disease 2019 (COVID-19). The pandemic has claimed more than 7 million lives since its outbreak at the beginning of 2020, ... -
Undersampled Radial STEAM MRI: Methodological Developments and Applications
(2018-03-09)The diffusion-weighted (DW) single-shot stimulated echo acquisition mode (STEAM) sequence offers DW MRI without susceptibility artifacts which severely hamper diagnostic applications when using conventional echo-planar ... -
Understanding Nucleosome Assembly Regulation in Drosophila melanogaster
(2022-06-24)Nucleosomes consist of a complex of DNA and an octameric core of histone proteins, which represent the basic subunit of chromatin. The N-terminal tails of histones are target for chemical modifications, which play an ... -
Understanding Visual Attention: A Multifaceted Approach
(2025-08-21)We all have an intuitive sense of what attention is, yet defining it precisely remains challenging. While research in psychology and neuroscience has explored its origins, mechanisms, and influence on behaviour for over a ... -
Unexpected Evolutionary Invariance: Understanding a Major Transition in the Evolution of Networks of Orientation Selective Neurons
(2025-10-15)The mechanisms of development and function of neural architectures involved in information detection and processing of sensory stimuli is still largely unknown, despite these processes being crucial in mediating interactions ... -
Universal Computation and Memory by Neural Switching
(2011-10-21)Complex heteroclinic networks of connected saddle states persistently emerge in a broad range of dynamical systems and may reliably encode ``memory items'' as specific switching trajectories. ... -
Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation
(2020-06-18)The hallmark of adaptive immunity is the production of specific antibodies. This process is initiated upon the ligation of the B cell antigen receptor (BCR) which activates multiple intracellular signaling cascades through ... -
Unraveling the Role of TET3 in regulating EndMT in Cardiac Fibrosis
(2023-02-10)DNA methylation and subsequent silencing of gene expression is associated with disease states including tumorigenesis and fibrosis. Although DNA methylation is a dynamic and reversible process, the mechanisms of and ...