Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 135-154 of 1267
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Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
Chaotic Dynamics in Networks of Spiking Neurons in the Balanced State
(2011-05-30)The brain processes sensory information about the outside world in large complex networks of neurons which communicate with short electrical pulses called action potentials or spikes. The ... -
Chaotic Neural Circuit Dynamics
(2018-02-09)Information is processed in the brain by the coordinated activity of large neural circuits. Yet, we are still only starting to understand how this high-dimensional complex system gives rise to functions such as processing ... -
Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis
(2021-06-03)The skin represents the largest organ of the mammalian body and acts as the primary barrier against environmental stressors. Cellular maintenance and regeneration of the skin is orchestrated by a variety of skin stem ... -
Characterisation of killer immunoglobulin-like receptors in rhesus macaques (Macaca mulatta)
(2012-10-22)Rhesus macaques are important animal models of human diseases in which NK cells play significant roles. Whereas data on KIR genetic variability were recently published, data on KIR protein expression was not available until ... -
Characterisation of primate primordial germ cells in vitro
(2024-06-17)Primordial germ cells (PGCs) are embryonic precursors of sperm and eggs, responsible for passing on genetic and epigenetic information throughout the generations. For certain mammalian species, the development of PGCs can ... -
Characterization and Engineering of the 'Biocatalytic' Transketolase from Geobacillus stearothermophilus
(2025-04-24)Biocatalysis is the use of living organisms or their components to speed up chemical reactions, and is a powerful tool to enhance efficiency and sustainability in manufacturing processes. Carboligation, the formation of ... -
Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis
(2024-07-23)Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ... -
Characterization of Acyltransferases in Neutral Lipid Synthesis
(2021-04-23)Wax ester (WE) are neutral lipids, which consist of a fatty acid and a fatty alcohol moiety connected by an ester bond. WE are synthesized via two reactions from acyl-coenzyme A (CoA)/acyl carrier protein (ACP) substrates. ... -
Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism
(2017-09-11)Autism is known as a heritable neurodevelopmental disorder, diagnosed prior to the age of three years in humans based on three major domains: (1) impairment in social interaction (2) communication deficits (3) restricted ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Characterization of distinct contrast- and luminance-sensitive pathways in the Drosophila visual system
(2020-02-03)Visual systems are capable of extracting relevant information from dynamically changing environments. This allows animals to locate objects, escape predators and collisions or estimate self-motion, among others. During the ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Characterization of host cell factors used by emerging coronaviruses for entry into target cells
(2020-07-24)Human coronaviruses (HCoV) mainly cause common cold-like symptoms. However, in the last two decades the emerging coronaviruses the severe acute respiratory syndrome coronavirus (SARS-CoV) (in 2002), Middle East respiratory ... -
Characterization of immune responses in the meninges
(2022-06-14)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which is characterized by plaque-like demyelination in both white and grey matter and diffuse neurodegeneration. A T cell-driven ... -
Characterization of inner mitochondrial membrane architecture
(2016-08-26)The inner membrane of mitochondria is extensively folded and displays a complex architecture. Cristae junctions are highly curved tubular openings that separate the cristae membrane from the inner boundary membrane. They ... -
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development
(2011-03-21)In eukaryotic cells the genome is packaged into chromatin, which is composed of core histones (H2A, H2B, H3, H4), non-histone proteins and DNA. Packaging of DNA into distinct chromatin ... -
Characterization of microbial communities in carbonate sediments
(2021-11-25)Microbial communities in carbonate sediments from the alkaline Lake Neusiedl and the Aldabra Atoll were characterized. The aim was to determine the microbial community composition and function in the context of their ... -
Characterization of microglial Rab7 knockout on amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
(2019-11-08)Microglia are the innate immune cells of the brain. In neurodegeneration, such as Alzheimer’s disease, these cells are involved in clearance of cellular debris and extracellular aggregates of misfolded proteins like amyloid ... -
Characterization of mRNA export and nuclear quality control under heat stress in the yeast Saccharomyces cerevisiae
(2017-05-17)Elevated temperatures and other changes of the environment a cell lives in, can have tremendous impact on cellular processes and integrity. To counteract these threats, cells have established various mechanisms to avoid ...