Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 142-161 of 1236
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Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism
(2017-09-11)Autism is known as a heritable neurodevelopmental disorder, diagnosed prior to the age of three years in humans based on three major domains: (1) impairment in social interaction (2) communication deficits (3) restricted ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Characterization of distinct contrast- and luminance-sensitive pathways in the Drosophila visual system
(2020-02-03)Visual systems are capable of extracting relevant information from dynamically changing environments. This allows animals to locate objects, escape predators and collisions or estimate self-motion, among others. During the ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Characterization of host cell factors used by emerging coronaviruses for entry into target cells
(2020-07-24)Human coronaviruses (HCoV) mainly cause common cold-like symptoms. However, in the last two decades the emerging coronaviruses the severe acute respiratory syndrome coronavirus (SARS-CoV) (in 2002), Middle East respiratory ... -
Characterization of immune responses in the meninges
(2022-06-14)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which is characterized by plaque-like demyelination in both white and grey matter and diffuse neurodegeneration. A T cell-driven ... -
Characterization of inner mitochondrial membrane architecture
(2016-08-26)The inner membrane of mitochondria is extensively folded and displays a complex architecture. Cristae junctions are highly curved tubular openings that separate the cristae membrane from the inner boundary membrane. They ... -
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development
(2011-03-21)In eukaryotic cells the genome is packaged into chromatin, which is composed of core histones (H2A, H2B, H3, H4), non-histone proteins and DNA. Packaging of DNA into distinct chromatin ... -
Characterization of microbial communities in carbonate sediments
(2021-11-25)Microbial communities in carbonate sediments from the alkaline Lake Neusiedl and the Aldabra Atoll were characterized. The aim was to determine the microbial community composition and function in the context of their ... -
Characterization of microglial Rab7 knockout on amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
(2019-11-08)Microglia are the innate immune cells of the brain. In neurodegeneration, such as Alzheimer’s disease, these cells are involved in clearance of cellular debris and extracellular aggregates of misfolded proteins like amyloid ... -
Characterization of mRNA export and nuclear quality control under heat stress in the yeast Saccharomyces cerevisiae
(2017-05-17)Elevated temperatures and other changes of the environment a cell lives in, can have tremendous impact on cellular processes and integrity. To counteract these threats, cells have established various mechanisms to avoid ... -
Characterization of NDR kinase signalling pathways during septum formation in Neurospora crassa
(2013-11-27)Cytokinesis is a fundamental cellular process essential for cell proliferation of unicellular and multicellular organisms. The molecular pathways that regulate cytokinesis are highly complex and involve a large number of ... -
Characterization of neuroligin 4, a protein involved in autism spectrum disorders
(2012-11-06)Neuroligins (NLs) are ubiquitous postsynaptic adhesion proteins that are essential for synaptic maturation and function. Of the four NL isoforms expressed in the central nervous system (CNS), NL4 is of particular interest ... -
Characterization of Novel Proteins Modulating the Nanoscale Organization of the Membrane-Associated Periodic Skeleton in Neurons
(2024-09-19)The Membrane-associated Periodic Skeleton (MPS) is a lattice located underneath the neuronal plasma membrane, characterized by a distinctive ~190 nm periodic architecture imposed by the nanoscale arrangement of its main ... -
Characterization of Npl3-mediated RNA quality control in Saccharomyces cerevisiae
(2018-12-19)During all steps of nuclear RNA maturation, aberrant RNAs can be generated. However, nuclear quality control mechanisms ensure that immature or aberrant RNAs are retained in the nucleus and subsequently degraded to prevent ... -
Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis
(2011-02-09)Olfactory receptors comprise the largest multigene family of G protein-coupled receptors in organisms ranging from fish to primates and are the detectors of thousands of odorant molecules. ... -
Characterization of Rho GTPase GAP/GEF modules in the ascomycete Neurospora crassa
(2015-12-22)Rho (Ras homologue) GTPases are members of the Ras superfamily and known as key players in highly conserved signaling pathways regulating cellular processes like metabolism, survival, differentiation, vesicle transport and ... -
Characterization of RIS presynaptic circuits for sleep regulation in Caenorhabditis elegans
(2019-07-03)Within the field of sleep research, it is well established that all organisms, which possess a nervous system, need to sleep. This underlines the severity of sleep functions. In humans, sleep is essential for memory function, ... -
Characterization of RNA-modifying enzymes and their roles in diseases
(2017-11-29)More than 150 types of chemical modifications have been identified in cellular RNAs (collectively called ‘’the epitranscriptome’’), and such modifications have emerged as important regulators of gene expression. Despite ... -
Characterization of Small Conductance Ca2+-activated K+ Channel 2 Isoforms in Mouse Brain.
(2007-11-06)Small conductance calcium-activated potassium channels (SK channels) are potassium selective and voltage independent channels, which are activated by intracellular calcium during an action ...