Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 259-278 of 1216
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Development of mass spectrometry-based proteome analysis workflows for the systematic study of cardiac disease research models
(2024-09-26)A specific variant of genetic mutation in the phospholamban gene expresses a cardiac phospholamban protein lacking the arginine amino acid at position 14 (R14Δ-PLN). The mutation is believed to have a founder in the ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Development of methods to decrease aneuploidy in mammalian oocytes
(2022-05-24)Maternal mRNAs accompany and control all processes from the onset of meiosis until the blastocyst stage when the maternal pool of mRNAs is fully replaced by the emryonic mRNA set. The successful development of blastocysts ... -
Development of Nanobodies to Image Synaptic Proteins in Super-Resolution Microscopy
(2018-10-17)In the recent decades, super resolution microscopy substantially contributed to the investigation of subcellular structures. A prominent example is the molecular organization of the synapse which is known to be vital for ... -
Development of new computational methods for non-invasive brain stimulation
(2014-07-21)In this thesis, we explore the use of computational models that numerically solve the electric field during TMS and tDCS in order to improve the spatial precision of these methods. For TMS, we validate the prediction of ... -
Development of new methods in fluorescence microscopy
(2015-12-02)In recent years, advancements in single-molecule imaging techniques have enabled scientists to study in great detail the cells and relevant physiological processes, including neurons and the communication between them. ... -
Development, characterization, and application of RNA catalysts for in situ labeling of target RNA molecules
(2020-08-07)RNA molecules play a diverse set of crucial roles in biological systems. Studying various aspects of RNA biology such as RNA transport, localization, degradation, and structural dynamics is therefore of utmost significance. ... -
Developmental Studies of Appendage Patterning and Formation in Spiders
(2016-11-21)In the animal kingdom arthropods are unparalleled in species number and diversity. Especially their appendages show a great morphological diversity and are adapted for different purposes like feeding, walking, flying, ... -
Developmental Studies on Eye Types and Pedipalps in Parasteatoda tepidariorum
(2017-12-21)Arthropods are by far the most species rich phylum in the animal kingdom and their evolutionary success is at least in part rooted in their diverse morphology. Despite these morphological differences, arthropods share a ... -
Differential metabolic alterations in cortical cell types by feeding a ketogenic diet
(2020-06-18)The suckling period of rodents is accompanied by marked ketosis as a result of the high fat content of maternal milk. During this time, ketone bodies are the major source of energy for the brain. After weaning when the ... -
Diffusion and Flow on Microscopic Length Scales Studied with Fluorescence Correlation Spectroscopy
(2012-10-30)The physics of fluids on microscopic lengthscales is fundamentally different from the one governing macroscopic fluid phenomena. On lengthscales up to a few micrometer, inertial forces of small particles and fluid ... -
Dinamics of Kv10.1 expression through the cell cycle of cancer and non-cancer cells
(2015-05-12)Kv10.1 is a voltage dependent potassium channel. Its expression has been reported to be widespread in clinical tumors samples of diverse origin. In contrast, expression in normal non-neural tissue has been detected at low ... -
Direct Numerical Simulation of Transition to Turbulence and Turbulence Control in Pipe Flow
(2014-10-28)The subject of this thesis is the transition to turbulence and turbulence control in pipe flow. In pipes turbulence arises despite the linear stability of the laminar flow (subcritical transition) and directly from onset ... -
Discovery and prediction of protein binding sites in DNA and RNA sequences using Bayesian Markov models
(2021-04-23)Transcription factors control the essential step of gene expression via recognizing the over- represented binding sites (or motifs) on the genome. One crucial task is to accurately predict these binding sites on the ... -
Disinhibitory circuit motifs in the mouse primary somatosensory (barrel) cortex
(2025-02-24)The barrel cortex is the part of the rodent neocortex where the tactile information from the whiskers is processed. In the barrel cortex, each whisker is represented by a single cortical column isomorphic to the whiskers ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
Dissection of the molecular machinery of micro- and macronucleophagy
(2019-11-07)A highly conserved pathway required for cellular homeostasis, autophagy facilitates degradation and recycling of various cellular components. Involvement of autophagy in medical context has made associated research a highly ... -
Dlk1 Membrane-to-Nuclear Signalling During Motor Neuron Functional Diversification
(2017-11-20)Motor neurons of the spinal cord and hindbrain are responsible for translating neural commands into movements. For the execution of smooth movements, it is necessary that motor neuronal impulses are in turn translated into ... -
Dopaminergic Impact on External Brain Stimulation-Induced Neuroplasticity in Human Motor Cortex
(2009-06-19)Dopamine (DA) is involved in learning and memory formation, which are thought to depend on synaptic modifications like long-term potentiation (LTP) and long-term depression (LTD). Despite ... -
Dopaminergic Modulation of Neuroplasticity in Humans- Contribuition of Receptor Subtypes and Dosage
(2014-09-29)From infancy up to adulthood and beyond, the brain reacts adaptively to the continuously changing environment. This capacity is termed “plasticity” and describes the ability of the brain to develop, react to environmental ...