Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 279-298 of 1182
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Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
Dynamic Temperature Mapping - Real-time Strategies and Model-based Reconstructions
(2017-02-09)The purpose of this thesis was to explore the potential of real-time MRI methods for temperature mapping during thermal procedures. This mainly included a comprehensive analysis of two different methods, i.e. proton resonance ... -
Dynamics and Driving Forces of Macromolecular Complexes
(2013-06-05)Many functions in living cells are governed by macromolecular complexes. To fully describe the underlying mechanisms, they have to be understood at atomic level. The present study combines data obtained by X-ray crystallography ... -
Dynamics and Machine Learning Inference using Memory in Stochastic Biochemical Reaction Networks
(2024-06-24)In this thesis we study the dynamics of non-equilibrium stochastic chemical reaction networks with a special focus on biochemical networks. In the regime of large intrinsic noise where the numbers of participating molecules ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Dynamics and regulation of the mitochondrial translation machinery
(2024-11-15)Throughout this project, we have successfully established and implemented a ribosome profiling protocol tailored for examination of translating mitochondrial ribosomes, thereby affording a deeper understanding of mitochondrial ... -
Dynamics and self-organization of membrane-bound minimal actin and actomyosin cortices based on ezrin-PtdIns[4,5]P2 linkage
(2022-11-22)The cellular cortex is a thin actin layer attached to the cytoplasmatic plasma membrane leaflet of mammalian cells. Through a complex interaction with hundreds of actin binding proteins (ABPs), controlling e.g. the cortex ... -
Dynamics of Surfactants at Soft Interfaces using Droplet-Based Microfluidics
(2016-01-26)In this work, I studied the impact of surfactants on interfacial phenomena out of equilibrium. I investigated three different effects, (1) the stabilisation of interfaces upon surfactant adsorption (adsorption kinetics), ... -
Early Active Zone Assembly in Drosophila
(2010-05-06)The dissection of presynaptic assembly processes has proven difficult in the past. Apart from genetic redundancies, this likely reflects a highly cooperative and regulated nature of synapse ... -
Early synaptic imbalance in genetic mice models of Autistic Spectrum Disorders
(2008-11-12)Autism and Rett Syndrome have been proposed to result from a dysfunction in postnatal or experience-dependent synaptic plasticity. Mice models in which selected candidate genes were mutated ... -
Ecdysone signaling and miRNA let-7 cooperate in regulating the differentiation of the germline stem cell progeny
(2015-05-06)Adult stem cells are found in most adult tissues where they are responsible for replacing cells that are lost due to turnover or injury. They have the unique ability to give rise to differentiated progeny, while at the ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Effects of arginine derivatives and oligopeptides on the physical properties of model membranes
(2021-02-16)Cell-penetrating peptides (CPPs) are often rich in arginine. They are able to cross cell membranes and carry other molecules into cells without being cytotoxic. The mechanisms by which they accomplish this are still ... -
Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat
(2011-04-21)Stress facilitates the development of psychiatric disorders in vulnerable individuals. Previous studies have well documented the impact of stress on glutamatergic excitatory transmission ... -
Effects of α/β/γ-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors
(2014-09-25)Parkinson’s disease (PD) is the second most common neurodegenerative disease and it affects more than 1% of the worlds population over the age of 65. A hallmark of PD is the appearance of Lewy bodies (LBs) throughout the ... -
Electrical Control of Droplet formation in Microfluidic Devices
(2014-09-23)This thesis presents both experimental investigations and demonstration on the use of an AC voltage induced electric field to actively control the size or frequencies of droplet generated in a microfluidic flow focusing ... -
Electrocutaneous stimulation to close the loop in myoelectric prosthesis control
(2017-08-09)Current commercially available prosthetic systems still lack sensory feedback and amputees are forced to maintain eye-contact with the prosthesis when interacting with their environment. Electrocutaneous stimulation is a ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Elongation factor P: mechanism of action and opportunities for drug design
(2023-07-24)EF-P is a conserved protein that has shape similarity to the tRNAs and binds to the E site of the ribosome. EF-P enhances the rate of peptide bond formation during the synthesis of polyPro sequences. In E. coli one third ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ...