Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 279-298 of 1218
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Down-Stream molecular Responses to Volatile Signaling in Roots
(2021-05-20)Plants, fungi, and prokaryotic organisms emit volatiles for inter-kingdom communication. Some volatiles are emitted in large quantities into the environment and act as climate relevant gases, others are released for ... -
Drift and stabilization of cortical response selectivity
(2021-08-02)Synaptic turnover and long term functional stability are two seemingly contradicting features of neuronal networks, which show varying expressions across different brain regions. Recent studies have shown, how both of these ... -
Droplet-based giant unilamellar vesicles as a tool for pore-spanning membrane preparation and transmembrane protein reconstitution
(2022-11-22)Model membranes represent a central tool to decipher complex processes of living cells. Giant unilamellar vesicles (GUVs) are of particular interest as they are cell-like in size, observable with optical microscopy and ... -
Drug Metabolism Determines Resistance of Colorectal Cancer to Resorcinol-Based HSP90 Inhibitors
(2014-11-04)Tumor cells are characterized by intrinsic proteotoxic stress and the accumulation of mutated proteins. Therefore, malignant cells depend on the activity of heat shock protein 90 (HSP90) much more than normal cells to ... -
Dual-AAV mediated transfer of full-length otoferlin cDNA into auditory inner hair cells and the effects of different mutations in the OTOF gene on the protein levels and cellular distribution of otoferlin in auditory inner hair cells
(2019-05-08)Otoferlin is a large multi-C2 domain protein indispensable for hearing and synaptic transmission in auditory inner hair cells (IHCs). Mutations within the OTOF gene, coding for otoferlin, cause non-syndromic recessive ... -
Dynamic changes in cytochrome c oxidase assembly and organization
(2016-08-24)The respiratory chain in the inner membrane of the yeast mitochondrion is organized as a network of individual complexes and large supercomplex structures. These supercomplexes are composed of dimeric complex III and one ... -
Dynamic fitness and horizontal gene transfer in stochastic evolutionary dynamics
(2013-03-12)The evolution of species is shaped by processes such as selection, mutations or genetic drift. Still, we are far away from a complete understanding of how these processes drive evolutionary dynamics in detail. Therefore, ... -
Dynamic interactions during ribosome targeting to the membrane
(2015-05-11)The signal recognition particle (SRP) and its receptor are the main components of the co-translational protein targeting pathway by which membrane proteins are targeted to the membrane. The co-translational targeting pathway ... -
Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
Dynamic Temperature Mapping - Real-time Strategies and Model-based Reconstructions
(2017-02-09)The purpose of this thesis was to explore the potential of real-time MRI methods for temperature mapping during thermal procedures. This mainly included a comprehensive analysis of two different methods, i.e. proton resonance ... -
Dynamics and composition of signaling droplets reveal an impact of cellular transport during B cell activation
(2025-03-13)B cell activation during immune responses relies on the signaling network downstream the B cell antigen receptor (BCR). BCRs engaged by an antigen recruit a plethora of signal transducers forming BCR signalosomes, which ... -
Dynamics and Driving Forces of Macromolecular Complexes
(2013-06-05)Many functions in living cells are governed by macromolecular complexes. To fully describe the underlying mechanisms, they have to be understood at atomic level. The present study combines data obtained by X-ray crystallography ... -
Dynamics and Machine Learning Inference using Memory in Stochastic Biochemical Reaction Networks
(2024-06-24)In this thesis we study the dynamics of non-equilibrium stochastic chemical reaction networks with a special focus on biochemical networks. In the regime of large intrinsic noise where the numbers of participating molecules ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Dynamics and regulation of the mitochondrial translation machinery
(2024-11-15)Throughout this project, we have successfully established and implemented a ribosome profiling protocol tailored for examination of translating mitochondrial ribosomes, thereby affording a deeper understanding of mitochondrial ... -
Dynamics and self-organization of membrane-bound minimal actin and actomyosin cortices based on ezrin-PtdIns[4,5]P2 linkage
(2022-11-22)The cellular cortex is a thin actin layer attached to the cytoplasmatic plasma membrane leaflet of mammalian cells. Through a complex interaction with hundreds of actin binding proteins (ABPs), controlling e.g. the cortex ... -
Dynamics of Surfactants at Soft Interfaces using Droplet-Based Microfluidics
(2016-01-26)In this work, I studied the impact of surfactants on interfacial phenomena out of equilibrium. I investigated three different effects, (1) the stabilisation of interfaces upon surfactant adsorption (adsorption kinetics), ... -
Early Active Zone Assembly in Drosophila
(2010-05-06)The dissection of presynaptic assembly processes has proven difficult in the past. Apart from genetic redundancies, this likely reflects a highly cooperative and regulated nature of synapse ... -
Early synaptic imbalance in genetic mice models of Autistic Spectrum Disorders
(2008-11-12)Autism and Rett Syndrome have been proposed to result from a dysfunction in postnatal or experience-dependent synaptic plasticity. Mice models in which selected candidate genes were mutated ... -
Ecdysone signaling and miRNA let-7 cooperate in regulating the differentiation of the germline stem cell progeny
(2015-05-06)Adult stem cells are found in most adult tissues where they are responsible for replacing cells that are lost due to turnover or injury. They have the unique ability to give rise to differentiated progeny, while at the ...