Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 299-318 of 1213
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Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat
(2011-04-21)Stress facilitates the development of psychiatric disorders in vulnerable individuals. Previous studies have well documented the impact of stress on glutamatergic excitatory transmission ... -
Effects of α/β/γ-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors
(2014-09-25)Parkinson’s disease (PD) is the second most common neurodegenerative disease and it affects more than 1% of the worlds population over the age of 65. A hallmark of PD is the appearance of Lewy bodies (LBs) throughout the ... -
Electrical Control of Droplet formation in Microfluidic Devices
(2014-09-23)This thesis presents both experimental investigations and demonstration on the use of an AC voltage induced electric field to actively control the size or frequencies of droplet generated in a microfluidic flow focusing ... -
Electrocutaneous stimulation to close the loop in myoelectric prosthesis control
(2017-08-09)Current commercially available prosthetic systems still lack sensory feedback and amputees are forced to maintain eye-contact with the prosthesis when interacting with their environment. Electrocutaneous stimulation is a ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Elongation factor P: mechanism of action and opportunities for drug design
(2023-07-24)EF-P is a conserved protein that has shape similarity to the tRNAs and binds to the E site of the ribosome. EF-P enhances the rate of peptide bond formation during the synthesis of polyPro sequences. In E. coli one third ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ... -
Endocrine control of T cell function and its implications for the pathogenesis of neuroinflammatory diseases
(2013-06-17)Insulin and GCs are two important endocrine regulators of mammalian body homeostasis and both impact on immune cell functions. Whereas GCs are in widespread use for the treatment of autoimmune diseases since the late 1950s, ... -
Engineered genetic tools for directed gene regulation
(2021-07-28)Genetic manipulation or genetic engineering is the ability to modify the behaviour of a gene or group of genes. In biological research, since nucleic acids were shown to be responsible for control of cellular functions and ... -
Engineering of a NIR fluorescent protein for live-cell nanoscopy
(2020-09-22)Since its first use as a genetically encoded fluorescent marker in 1994, GFP and its homologues have fundamentally revolutionized live-cell fluorescence imaging and became an essential tool for biomedical research. Many ... -
Enhancing visual cortical plasticity in mice by enriching their environment: a combined imaging and behavioural study
(2017-02-01)Brain plasticity is important not only for normal brain functions like learning and memory, but is also crucial for recovery after injuries. It has been shown that the environment has a great influence on brain plasticity. ... -
Environmental and genetic correlates of neuropsychiatric diseases and the role of erythropoietin/hypoxia in the brain as potential treatment targets
(2021-06-15)Neuropsychiatric disorders are relatively frequent and present a considerable burden to affected individuals and society. Disease etiology is often complex and patients exhibit large heterogeneity regarding disease causing ... -
Epigenetic Biomarker and Therapeutic Intervention for Dementia
(2021-01-11)Dementia is the most significant health challenge in modern times, currently affecting over 50 million people worldwide. The number of people afflicted with this disorder is on the rise and expected to double by 2025. ... -
Epigenetic Modulation in Alzheimer's Disease: Function of Hippocampal microRNAs
(2015-12-04)MicroRNAs (miRNA) are small non-coding RNAs that play a critical role in the regulation of gene expression programs and thus key mediators of cellular homeostasis. There is increasing evidence that deregulation of miRNAs ... -
Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Epigenetic Regulation of Tumor Cell Phenotype
(2017-04-03)The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Epigenomic Imaging of Neuropsychiatric Diseases
(2013-12-13)Schizophrenia is a severe neuropsychiatric disorder with high phenotypic complexity and multifactorial inheritance. Cognitive dysfunctions have been identified as the core feature of the disease and they are resistant to ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ...