Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 299-318 of 1174
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Engineered genetic tools for directed gene regulation
(2021-07-28)Genetic manipulation or genetic engineering is the ability to modify the behaviour of a gene or group of genes. In biological research, since nucleic acids were shown to be responsible for control of cellular functions and ... -
Engineering of a NIR fluorescent protein for live-cell nanoscopy
(2020-09-22)Since its first use as a genetically encoded fluorescent marker in 1994, GFP and its homologues have fundamentally revolutionized live-cell fluorescence imaging and became an essential tool for biomedical research. Many ... -
Enhancing visual cortical plasticity in mice by enriching their environment: a combined imaging and behavioural study
(2017-02-01)Brain plasticity is important not only for normal brain functions like learning and memory, but is also crucial for recovery after injuries. It has been shown that the environment has a great influence on brain plasticity. ... -
Environmental and genetic correlates of neuropsychiatric diseases and the role of erythropoietin/hypoxia in the brain as potential treatment targets
(2021-06-15)Neuropsychiatric disorders are relatively frequent and present a considerable burden to affected individuals and society. Disease etiology is often complex and patients exhibit large heterogeneity regarding disease causing ... -
Epigenetic Biomarker and Therapeutic Intervention for Dementia
(2021-01-11)Dementia is the most significant health challenge in modern times, currently affecting over 50 million people worldwide. The number of people afflicted with this disorder is on the rise and expected to double by 2025. ... -
Epigenetic Modulation in Alzheimer's Disease: Function of Hippocampal microRNAs
(2015-12-04)MicroRNAs (miRNA) are small non-coding RNAs that play a critical role in the regulation of gene expression programs and thus key mediators of cellular homeostasis. There is increasing evidence that deregulation of miRNAs ... -
Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Epigenetic Regulation of Tumor Cell Phenotype
(2017-04-03)The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Epigenomic Imaging of Neuropsychiatric Diseases
(2013-12-13)Schizophrenia is a severe neuropsychiatric disorder with high phenotypic complexity and multifactorial inheritance. Cognitive dysfunctions have been identified as the core feature of the disease and they are resistant to ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Establishing parameters for the characterization of rare neurometabolic and neurodegenerative diseases using mass-spectrometry based Metabolomics
(2021-10-18)Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead ... -
Evaluating the function of the Aryl Hydrocarbon Receptor in CNS autoimmunity
(2018-12-07)The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor highly expressed within the immune and nervous system. Structurally diverse endogenous and synthetic ligands activate AhR, including dietary, ... -
Evaluation of genetic engineering and genome editing tools to develop multifactorial reproductive sterility or killing sperm systems for the improvement of the Sterile Insect Technique
(2020-11-20)Insects fulfill fundamental roles for the preservation of ecosystems such as pollination, but also represent key agricultural pests and human disease vectors accounting for immense economic losses and approximately one ... -
Evolution of central complex development: Cellular and genetic mechanisms
(2019-11-11)Brains are conserved between insect species, as they consist of a set of anatomically similar areas, or neuropils. Simultaneously, these neuropils differ in size, shape, position and developmental timing between insect ... -
Evolutionary dynamics in changing environments
(2018-06-12)Evolution can be understood as an optimization mechanism on the fitness function, which is defined as the reproductive success of a species. If the environmental conditions remain constant, the stationary states of the ... -
Excitation-Secretion Coupling of Dense-Core Vesicle Release
(2023-07-18)Dense-core vesicles (DCVs) are membrane-bound organelles present in many secretory cells. Depending on cell type, DCVs package and release various types of cargo, such as neuronal peptides, proteins, neurotrophins, ATP, ... -
Experimental investigation of cloud droplet dynamics at the research station Schneefernerhaus
(2021-11-18)The collision–coalescence of droplets in turbulence is responsible for the fast growth of cloud droplets from 15 to 40 μm in radius, but how exactly it causes this quick growth is not understood. The growth of cloud ... -
Experimental investigation on the influence of rotation on thermal convection
(2022-10-18)We report on experimental measurements of rotating Rayleigh-Bénard convection to study the influence of the Coriolis force on the heat transport and the flow structure. Two experimental setups were used. The first is a ...