Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 319-338 of 1220
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Epigenomic Imaging of Neuropsychiatric Diseases
(2013-12-13)Schizophrenia is a severe neuropsychiatric disorder with high phenotypic complexity and multifactorial inheritance. Cognitive dysfunctions have been identified as the core feature of the disease and they are resistant to ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Establishing parameters for the characterization of rare neurometabolic and neurodegenerative diseases using mass-spectrometry based Metabolomics
(2021-10-18)Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead ... -
Evaluating the function of the Aryl Hydrocarbon Receptor in CNS autoimmunity
(2018-12-07)The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor highly expressed within the immune and nervous system. Structurally diverse endogenous and synthetic ligands activate AhR, including dietary, ... -
Evaluation of genetic engineering and genome editing tools to develop multifactorial reproductive sterility or killing sperm systems for the improvement of the Sterile Insect Technique
(2020-11-20)Insects fulfill fundamental roles for the preservation of ecosystems such as pollination, but also represent key agricultural pests and human disease vectors accounting for immense economic losses and approximately one ... -
Evolution of central complex development: Cellular and genetic mechanisms
(2019-11-11)Brains are conserved between insect species, as they consist of a set of anatomically similar areas, or neuropils. Simultaneously, these neuropils differ in size, shape, position and developmental timing between insect ... -
Evolutionary dynamics in changing environments
(2018-06-12)Evolution can be understood as an optimization mechanism on the fitness function, which is defined as the reproductive success of a species. If the environmental conditions remain constant, the stationary states of the ... -
Excitation-Secretion Coupling of Dense-Core Vesicle Release
(2023-07-18)Dense-core vesicles (DCVs) are membrane-bound organelles present in many secretory cells. Depending on cell type, DCVs package and release various types of cargo, such as neuronal peptides, proteins, neurotrophins, ATP, ... -
Experimental investigation of cloud droplet dynamics at the research station Schneefernerhaus
(2021-11-18)The collision–coalescence of droplets in turbulence is responsible for the fast growth of cloud droplets from 15 to 40 μm in radius, but how exactly it causes this quick growth is not understood. The growth of cloud ... -
Experimental investigation on the influence of rotation on thermal convection
(2022-10-18)We report on experimental measurements of rotating Rayleigh-Bénard convection to study the influence of the Coriolis force on the heat transport and the flow structure. Two experimental setups were used. The first is a ... -
Exploration of cargo spectrum and NES patterns recognized by the exportin CRM1
(2014-10-15)The nuclear envelope (NE) subdivides eukaryotic cells into a nuclear and a cytoplasmic compartment, forcing material exchange between these two compartments to proceed through the nuclear pore complexes (NPCs). While ... -
Exploring the human Hsp70-Hop-Hsp90 system for Tau recognition
(2022-03-22)Molecular chaperones are diligent helpers of the cell that ensure a well-balanced proteome by regulating protein production, protein folding, refolding and holding as well as protein degradation. In doing so, molecular ... -
Exploring the neural basis of touch through selective and stable genetic tagging in the chick somatosensory system
(2013-01-03)The assembly of circuitries for somatosensory perception relies on a complex interplay of neuronal diversification, specification, phenotypic modulation and establishment of precise connectivity patterns during embryogenesis. ... -
Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells
(2013-09-04)Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed ... -
Expression and properties of neuronal MHC class I molecules in the brain of the common marmoset monkey
(2009-11-13)Several recent studies have highlighted the important role of immunity-related molecules in synaptic plasticity processes in the developing and adult rodent brain. It has been suggested that neuronal MHC (major ... -
Extending Resolution in All Directions: Image Scanning Microscopy and Metal-induced Energy Transfer
(2019-03-18)Fluorescence microscopy is a powerful tool in the life sciences and is used to study structure and function on length scales from cells down to single molecules. In recent years, fluorescence microscopy has seen enormous ... -
Eye, hand and space representations and causal interference in bihemispheric pulvinar-parietal circuitry
(2019-05-29)Recent research proposes that a proper action is the outcome of continuous competition between multiple frontoparietal neuronal representations of possible response options and this competition is biased by the input ... -
Fast and Robust Multi-Dimensional Cardiac Magnetic Resonance Imaging
(2020-09-02)Magnetic Resonance Imaging (MRI) has become an almost indispensable tool in hospitals worldwide as it provides significant and unique information for the assessment of various disease and injuries. However, MRI is an ... -
Feature Selectivity in Synthetic Neuronal Networks
(2024-06-06)A fundamental property of neurons in the primary visual cortex is their preference for orientation of edges. In primates and carnivores orientation selective neurons are organized into functional domains that are arranged ...