Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 360-379 of 1236
-
From Paramagnetic Proteins to Field Alignment of Small Molecules
(2022-03-17)In this dissertation we show how to push the boundaries of structure elucidation using tensorial NMR parameters. Possible sources for these effects are paramagnetic centers or molecular alignment, and they contain valuable ... -
From screening to function - Evolutionary conservation of novel JAK/STAT signal transduction pathway components
(2007-04-03)Signal transduction pathways mediating the exchange of information between cells are essential for development, cellular differentiation and homeostasis. Their dysregulation is also frequently ... -
From vision to action: Hand representations in macaque grasping areas AIP, F5, and M1
(2014-12-19)Grasping and manipulating objects of different shapes is a fundamental feature of the primate hand. This skill requires the transformation of visual object information into corresponding hand actions. In the primate brain ... -
Fullerene-Nitroxide Derivatives as Potential Polarizers for Dynamic Nuclear Polarization (DNP) in Liquid State
(2016-09-12)Nuclear magnetic resonance spectroscopy and imaging (NMR/MRI) are widely applied methods for non-destructive analysis of biological systems, materials and medical applications. Dynamic nuclear polarization (DNP) is a method ... -
Function and homeostasis of non-proteinogenic amino acids in Bacillus subtilis
(2024-07-23)The gram-positive soil bacterium Bacillus subtilis lives in a constantly changing environment, requiring rapid adaptation to survive and thrive. This forces the bacteria to adapt to nutrient availability or stressful ... -
Function of Cuticular Waxes in Plant Response to Wounding
(2019-08-27)Neutral lipids, such as triacylglycerol (TAG) and wax are essential metabolites for plants. TAG is the most abundant storage compound in all eukaryotes. It plays an important role in plant germination but also in lipid ... -
Function of the INA complex in assembly of the mitochondrial oxidative phosphorylation system
(2017-07-11)The majority of cellular ATP is produced by the mitochondrial F1Fo-ATP synthase, also called complex V, which consists of nuclear- and mitochondrial-encoded subunits. In order to form a functional enzyme, its proteins ... -
Function of the α/β-hydrolase fold family proteins Pummelig (CG1882) and Hormone-sensitive lipase in the Drosophila melanogaster lipid metabolism
(2016-09-30)To maintain energy homeostasis, all organisms need to adjust the generation and mobilization of their energy stores. The key molecules for energy storage are neutral lipids, mainly triacylglycerides (TAGs), which accumulate ... -
Functional analyses of RNA helicases in human ribosome biogenesis
(2019-10-30)Eukaryotic ribosomes are essential ribonucleoprotein (RNP) complexes consisting of four ribosomal RNAs (18S, 5S, 5.8S, 28S/25S) and approximately 80 ribosomal proteins, which are required for the process of translating the ... -
Functional Analysis of E3 Ubiquitin Ligases in Developing Neurons
(2019-08-15)Neuronal development starts after the closure of the neural tube when neural stem cells begin to divide asymmetrically at the ventricular zone of the forebrain. Newborn neurons then migrate vertically from the ventricular ... -
Functional analysis of genomically linked NLR proteins in plant innate immunity
(2020-12-11)The translocation of nuclear localization signal (NLS)-containing proteins through nuclear pore complexes (NPC) depends on transport adapters of the importin-α family that recognize and directly bind NLSs to recruit their ... -
Functional Analysis of Heat Shock Protein HSPA4
(2010-11-17)The aims of this study were to determine the underlying causes of male infertility, growth retardation and cardiac hypertrophy in Hspa4-/- mice. In order to identify the spermatogenic ... -
Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells
(2011-09-15)Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and ... -
Functional Analysis of Paired NLR Immune Receptors in Plant Immunity
(2024-03-21)The Arabidopsis gene AT3G04210 encodes a truncated Toll/interleukin-1 receptor nucleotide-binding leucine-rich repeat (TIR-NB-LRR or TNL) protein that is lacking the canonical C-terminal LRR domain of NLRs, and is named ... -
Functional analysis of Prdm14 during Xenopus embryogenesis
(2016-06-23)Prdm14 is a member of the conserved family of Prdm proteins, which are emerging as crucial regulators of multiple early developmental processes and diseases. Members of the Prdm family are characterized by the presence ... -
Functional analysis of the parkinsonism-associated protein FBXO7 (PARK15) in neurons
(2017-09-07)Parkinson's disease (PD) is a debilitating neurodegenerative disease affecting the elderly population. It has been a challenge elucidating the molecular mechanisms underlying the selective loss of dopaminergic neurons, ... -
Functional analysis of the CNS-specific F-box protein FBXO41 in cerebellar development
(2015-10-16)Neurodevelopment is a highly dynamic process governed by the tight orchestration of events such as neurogenesis, neuronal migration, morphogenesis and synaptogenesis that ultimately shape the brain. These neurodevelopmental ... -
Functional analysis of the Drosophila gene smallish (CG43427)
(2013-09-18)The establishment and maintenance of cell polarity is crucial for the function of many cell types in multicellular organisms. Especially in epithelial tissues, cell polarity is connected to the regulation of cell adhesion ... -
Functional and mechanistic characterization of the F-box protein Fbxw5
(2011-08-09)Targeted protein ubiquitylation that occurs in eukaroytes is often performed by cullin-RING-based E3 Ubiquitin ligases (CRLs), a superfamily of E3s. These types of ligases are composed of ... -
Functional and structural analysis of carbonic anhydrases from the filamentous ascomycete Sordaria macrospora
(2014-05-14)Carbonic anhydrases (CAs) are metalloenzymes catalyzing the rapid and reversible hydration of carbon dioxide to bicarbonate (hydrogen carbonate) and protons. CAs have been identified in archaea, bacteria and eukaryotes and ...