Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 388-407 of 1267
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Functional analysis of the Drosophila gene smallish (CG43427)
(2013-09-18)The establishment and maintenance of cell polarity is crucial for the function of many cell types in multicellular organisms. Especially in epithelial tissues, cell polarity is connected to the regulation of cell adhesion ... -
Functional and mechanistic characterization of the F-box protein Fbxw5
(2011-08-09)Targeted protein ubiquitylation that occurs in eukaroytes is often performed by cullin-RING-based E3 Ubiquitin ligases (CRLs), a superfamily of E3s. These types of ligases are composed of ... -
Functional and structural analysis of carbonic anhydrases from the filamentous ascomycete Sordaria macrospora
(2014-05-14)Carbonic anhydrases (CAs) are metalloenzymes catalyzing the rapid and reversible hydration of carbon dioxide to bicarbonate (hydrogen carbonate) and protons. CAs have been identified in archaea, bacteria and eukaryotes and ... -
Functional and Structural Characterization of the DEAH-box Helicase Prp43
(2022-11-24)RNA helicases of the DEAH-box family fulfill essential functions in various aspects of RNA metabolism by reorganizing structured RNAs and RNPs through ATP-dependent motility in 3’ to 5’ direction along single-strands. Prp43 ... -
Functional Annotation of Gretchen Hagen 3 Enzymes
(2024-07-05)Plants employ a multitude of phytohormones to regulate all aspects of their physiology ranging from their development to specific, environment-dependent responses to threats and other cues. The integration of all these ... -
Functional characterisation of DHX proteins in the regulation of RNA metabolism and genome stability
(2023-08-08)Cells contain a multitude of different RNAs, which are highly versatile biomolecules that have crucial functions in almost all cellular processes. Furthermore, the inter-relationship between RNA and proteins is essential, ... -
Functional characterisation of RNA helicases in the remodelling of pre-ribosomal subunits
(2018-07-13)DEAD/H-box RNA helicases are ubiquitously expressed enzymes, which are characterised by a conserved helicase core of two RecA-like domains containing sequence motifs required for substrate binding and hydrolysis of NTP. ... -
Functional characterization and application of 2',5'- branched RNA forming deoxyribozymes using lanthanides as cofactors
(2013-12-13)Deoxyribozymes or DNA catalysts are synthetic single stranded DNA molecules capable of catalysis for a wide range or reactions. Deoxyribozymes are discovered by in vitro selection and are mostly dependent on bivalent metal ... -
Functional characterization of Arabidopsis thaliana CC-type glutaredoxin ROXY9
(2023-07-10)Glutaredoxins are small proteins with a conserved thioredoxin fold. This fold allows for two functions, depending on the sequence of the active site. Class I glutaredoxins, which are characterized by a CPYC motif, show ... -
Functional characterization of C/D snoRNA-derived microRNAs
(2018-06-26)miRNAs are essential regulators of cell fate and involved in several human diseases, although their biogenesis is a well-accepted paradigm (microprocessor, Exp5, Dicer, and Argonaute). New evidence revealed different ... -
Functional Characterization of Early Visual Neurons Using Machine Learning
(2025-10-02)Understanding how early visual neurons represent and process sensory input remains a central challenge in systems neuroscience. Key questions include how these neurons encode visual information, how their receptive fields ... -
Functional characterization of npcRNAs - Intercellular trafficking of generegulatory components via exosomes
(2017-04-11)Exosomes are small extracellular vesicles (EVs) of endocytic origin and get released by a multitude of cell types. These vesicles have been found in a variety of body fluids and more recently an important role in exchanging ... -
Functional characterization of protease inhibitors involved in induced systemic defenses in poplar
(2024-02-05)Plants are constantly challenged with biotic stresses. Stresses are gaining importance due to climate change, where extended periods of warmer conditions are expected globally. Extended warmer temperatures also mean longer ... -
Functional characterization of transketolase-like proteins and related model systems with respect to thiamin diphosphate mediated chemistry
(2014-11-12)Transketolases (TKTs, E.C 2.2.1.1) are ubiquitous distributed enzymes among all three domains of life. TKTs require thiamin diphosphate (ThDP) and bivalent cations as catalytic cofactors. They fulfill their catalytic ... -
Functional connectivity of layer II/III and V GABAergic Martinotti cells in the primary somatosensory (barrel) cortex of mice
(2016-02-16)Although they represent only a small portion of cortical neurons, inhibitory interneurons take a major role in controlling the activity of cortical excitatory cells and, hence, cortical processing. The interaction of ... -
Functional connectivity of the L2/3 VIP-to-L4 SST cell circuit motif in the primary somatosensory and visual cortices of mouse
(2024-02-19)The mammalian cortex is comprised of a multitude of cell types, wired together in intricate circuit motifs, which are recruited during different behavioral scenarios. Broadly speaking, neocortical neurons can either be ... -
Functional Decomposition of Retinal Ganglion Cell Receptive Fields
(2023-02-23)The retina has the fascinating ability to extract various visual features from our surroundings. This feature detection is enabled by nonlinear operations in the retinal circuitry. The nonlinear processing is in part ... -
Functional dynamics of the anti-HIV lectin OAA and NMR methodology for the study of protein dynamics
(2016-01-26)Specific recognition between biomolecules is at the basis of all biological processes, and a mechanistic description of molecular recognition is crucial for a detailed understanding of these processes. Two limiting models ... -
Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ...