Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 408-427 of 1222
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Genetic manipulation of CNS cholesterol metabolism and its effects on cerebral β-amyloidosis
(2019-03-07)Accumulating evidence implicates cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD). However, the underlying mechanisms are not well understood. In the brain, cholesterol is synthesized locally by ... -
Genetic Targeting and Analysis of Parvalbumin and VGLUT3 Expressing Inhibitory Interneurons
(2012-03-12)GABAergic interneurons are a highly diverse class of cell types that play essential roles in regulating the input/output behaviour of pyramidal neurons and of other interneurons. Thereby, ... -
Genetics of Drosophila hearing
(2013-10-04)By probing Johnston’s organ function in mutant fly strains, mutations in forty-four genes that affect Drosophila hearing have been identified. This result increases the list of genes that are known for audition by 180 % ... -
Genome-wide analysis of mutually exclusive splicing
(2013-02-14)In recent years, advances in sequencing techniques resulted in an explosive increase in sequencing data. Here, computational methods and bioinformatical analyses are presented that provide approaches to keep pace with the ... -
Genomics and Phylogeny of Cytoskeletal Proteins: Tools and Analyses
(2013-02-05)Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein: Background Dynactin is a large multisubunit protein complex that enhances the processivity of cytoplasmic dynein and acts as an adapter ... -
Genomics of Hybridization and Adaptation in Primates
(2023-12-07)In chapter 1, we used high coverage (30X) whole genome sequences from 225 wild baboons (genus Papio) representing 19 geographic localities to investigate population genomics and inter-species gene flow. Our analyses provide ... -
Geophysical Pattern Formation of Salt Playa
(2019-03-21)Patterns, such as the hexagonal salt ridges that emerge in salt deserts around the world, are a common phenomenon in geophysical settings. They are similar to other natural phenomena such as fairy circles, columnar joints ... -
Giant plasma membrane vesicle-derived in vitro systems to study the structure and dynamics of CaV1.3 channel clusters
(2023-11-06)The voltage-gated calcium channel 1.3 (CaV1.3) has plentiful tasks in the human body. One of them is the excitation-contraction coupling within the heart, where it is known to form CaV1.3 channel cluster. However, their ... -
Glomerular information processing in Xenopus laevis
(2016-08-30)Olfactory glomeruli are structural and functional neuropils in the olfactory bulb. Although many olfactory receptor neurons (ORNs) project to one glomerulus, stimulusinduced responses within single glomeruli could not ... -
Glutamate-induced reversal of dopamine transport is mediated by the PKC signalling pathway
(2009-04-16)Dopaminergic neurons release their transmitter not only from axon terminals in the striatum but also from their long apical dendrites in the substantia nigra pars reticulata (SNr). Whether ... -
Grey matter pathology in multiple sclerosis
(2006-01-30)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. MS has traditionally been considered a disease affecting the well myelinated white matter ... -
Guiding Cancer Therapy: Evidence-driven Reporting of Genomic Data
(2018-11-26)Next Generation Sequencing (NGS) has been crucial for the breakthrough experienced by cancer genomics during the last decade. In turn, the knowledge gathered has fostered the development of targeted drugs and genomics-driven ... -
Head versus tail: germ cell-less initiates axis formation via homeobrain and zen1 in a beetle
(2018-08-27)The iBeetle screen project: Christiane Nüsslein-Volhard and Eric Wieschaus performed the first saturated forward genetic screen using random mutagenesis to identify genes important for embryonic development in Drosophila ... -
Hemisphere and region - specific effects of chronic stress in the rat prefrontal cortex
(2007-05-03)This thesis demonstrated that pyramidal neurons of the prelimbic and infralimbic area of the rat prefrontal cortex had an intrinsic morphological asymmetry in that pyramidal neurons in the ... -
High-bandwidth microrheology of cytoskeletal networks
(2012-02-08)The understanding of the material properties, the organization and the assembly of the cytoskeleton remains challenging. In this thesis the viscoelastic properties of cytoskeletal networks ... -
High-resolution structure determination of human spliceosome complexes by cryo-EM
(2019-02-14)The eukaryotic splicing of precursors to mRNA is facilitated by a highly dynamic, multi-megadalton macromolecular machine termed the spliceosome. The underlying chemical reaction features the excision of an intron, which ... -
Higher-Dimensional Extensions of Nonlinear Inverse Reconstruction for Magnetic Resonance Imaging
(2020-02-05)Even though magnetic resonance imaging (MRI) has become progressively faster in recent years, acquisition speed is still a problem in current clinical settings. Physiological constraints such as gradient-induced peripheral ... -
Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses
(2024-11-29)The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ... -
How introgressive hybridization shaped a genus' phylogeny
(2010-06-24)Primates are a diverse order, which exhibits numerous behavioral and morphological traits. To elucidate the evolutionary history of those traits an understanding of the phylogeny of the ... -
How nonlinear processing shapes natural stimulus encoding in the retina
(2022-05-31)Understanding natural vision is one of the fundamental goals of sensory neuroscience. The only part of the visual system that may currently be amenable to such a complete understanding is the vertebrate retina, where there ...