Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 42-61 of 1182
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Activation of the influenza virus hemagglutinin by type II transmembrane serine proteases
(2016-04-04)The influenza virus hemagglutinin (HA) mediates viral entry into target cells. HA is synthesized as an inactive precursor and depends on proteolytic processing by host cell proteases to become active. TMPRSS2, a member of ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Acto-myosin based mechano-sensitivity of cells - comparing human mesenchymal stem cells and differentiated cells
(2017-08-09)Within the last decades it was discovered that the cellular microenvironment plays an important role in cellular processes and cell fate can be directed by mechanical properties of the extracellular matrix (ECM), which can ... -
Adaptation und Aufmerksamkeit in higher visual perception
(2010-04-29)Seeing, at its simplest, is merely the registering of light and some reaction to it. Primate visual perception is not only a passive, feedforward absorption of information of the surrounding ... -
Advanced Image Deconvolution Techniques for Super-resolution Microscopy
(2019-09-12)In last decades, super-resolution fluorescence microscopy has seen its great development. Many super-resolution techniques are developed: the non-linear super-resolution techniques such as STED, PALM/STROM have provided ... -
Advances in enhanced multi-plane 3D imaging and image scanning microscopy
(2021-01-07)High-speed 3D optical microscopy is an indispensable requirement in studying rapid processes like signaling in neuronal networks, flagellar motion, or complex motion of living and highly dynamic subcellular components. ... -
Advances in real-time phase-contrast flow MRI and multi-echo radial FLASH
(2016-05-26)The conventional multi-echo radial fast flow angle shot (FLASH) utilizes bipolar readout gradients with the same amplitude and duration to sample echoes in a fly-back-and-forth manner. This strategy is inefficient with ... -
AfuSomA transcriptional network in human pathogen Aspergillus fumigatus
(2015-05-19)Fungal development is regulated by environmental stimuli via various signaling pathways. For instance, the cyclic AMP dependent protein kinase A (PKA) cascade is controlling development or pathogenesis in fungi as filamentous ... -
Ageing-associated myelin dysfunction as a driver of amyloid deposition in Alzheimer’s disease
(2022-01-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease with increasing prevalence due to longer lifespans in the human population. AD manifests as various age-associated cognitive impairments summarised under ... -
Aggregation and pattern formation in charged granular gases
(2019-09-11)Particulate flows of dielectric grains are almost always plagued by contact or triboelectrification and the resulting long-range electrostatic interactions. Extensive experimental, but rare theoretical, work is ongoing at ... -
Alpha-synuclein aggregation: visualization by X-ray techniques and its modulation by iron
(2017-09-06)Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. It’s a progressive disease that can be treated only symptomatically and its causes are still not fully understood. Two main factors ... -
Alpha-synuclein spreading pathology in Parkinson's disease: the influence of iron and the Rho-kinase inhibitor fasudil
(2020-06-05)Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease affecting approximately 1 % of the population above 60 years of age. It affects preferentially the extrapyramidal system, causing severe ... -
Altered Histone 4 K12 Acetylation is Associated with Age Dependent Memory Impairment in Mice
(2010-10-29)The remarkable capability of the nervous system of animals to adapt their behavioral responses to an ever-changing environmental conditions is thought to rely on the plasticity of neuronal ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
An Exploration of Real-Time Functional Magnetic Resonance Imaging Neurofeedback in Cognition
(2014-10-31)This thesis deals with an extensive exploration of the use of rt-fMRI neurofeedback in cognition. Specifically, the work presented here comprises the major steps in the development of a suitable experimental framework for ... -
An investigation of cell turnover in the planarian epidermis
(2024-04-16)Cell turnover is an important biological process for maintaining tissue homeostasis. During cell turnover, newly generated cells replace unwanted cells to balance the number of cells and ensure the functionality of a tissue. ... -
An omics analysis of genetic sleep loss in C. elegans
(2020-11-24)Sleep is a state of consciousness that has persisted through evolution and has become a necessity for animal welfare. In humans sleep loss has been shown to be inextricably intertwined with poor health. The prevalence ... -
Analyse der Jasmonoyl-Isoleucin-unabhängigen Funktion des Jasmonat-Rezeptors CORONATINE INSENSITIVE1 in Wurzeln von Arabidopsis thaliana
(2015-06-23)Verticillium longisporum is a soil borne vascular plant pathogen and a serious threat to the agronomically important oilseed rape, the source for biofuel and nutritional oil in Europe. In the interaction of the model plant ... -
Analysis of autoimmune lesions in grey matter
(2018-06-14)In the present thesis I demonstrated that pathogenic TβSyn cells of wild-type and receptor-transgenic origins could be reliably generated and used for inducing passive transfer EAE; active EAE could be reproducibly induced ...