Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 421-440 of 1237
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Glutamate-induced reversal of dopamine transport is mediated by the PKC signalling pathway
(2009-04-16)Dopaminergic neurons release their transmitter not only from axon terminals in the striatum but also from their long apical dendrites in the substantia nigra pars reticulata (SNr). Whether ... -
Grey matter pathology in multiple sclerosis
(2006-01-30)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. MS has traditionally been considered a disease affecting the well myelinated white matter ... -
Guiding Cancer Therapy: Evidence-driven Reporting of Genomic Data
(2018-11-26)Next Generation Sequencing (NGS) has been crucial for the breakthrough experienced by cancer genomics during the last decade. In turn, the knowledge gathered has fostered the development of targeted drugs and genomics-driven ... -
Head versus tail: germ cell-less initiates axis formation via homeobrain and zen1 in a beetle
(2018-08-27)The iBeetle screen project: Christiane Nüsslein-Volhard and Eric Wieschaus performed the first saturated forward genetic screen using random mutagenesis to identify genes important for embryonic development in Drosophila ... -
Hemisphere and region - specific effects of chronic stress in the rat prefrontal cortex
(2007-05-03)This thesis demonstrated that pyramidal neurons of the prelimbic and infralimbic area of the rat prefrontal cortex had an intrinsic morphological asymmetry in that pyramidal neurons in the ... -
High-bandwidth microrheology of cytoskeletal networks
(2012-02-08)The understanding of the material properties, the organization and the assembly of the cytoskeleton remains challenging. In this thesis the viscoelastic properties of cytoskeletal networks ... -
High-resolution morphometric analysis of synaptic vesicle formation
(2025-06-23)Synaptic vesicle (SV) biogenesis plays an important role in neurotransmission, yet the intricacies of SV formation remain a significant scientific challenge. In this PhD thesis, I seek to address both technical and biological ... -
High-resolution structure determination of human spliceosome complexes by cryo-EM
(2019-02-14)The eukaryotic splicing of precursors to mRNA is facilitated by a highly dynamic, multi-megadalton macromolecular machine termed the spliceosome. The underlying chemical reaction features the excision of an intron, which ... -
Higher-Dimensional Extensions of Nonlinear Inverse Reconstruction for Magnetic Resonance Imaging
(2020-02-05)Even though magnetic resonance imaging (MRI) has become progressively faster in recent years, acquisition speed is still a problem in current clinical settings. Physiological constraints such as gradient-induced peripheral ... -
Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses
(2024-11-29)The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ... -
How introgressive hybridization shaped a genus' phylogeny
(2010-06-24)Primates are a diverse order, which exhibits numerous behavioral and morphological traits. To elucidate the evolutionary history of those traits an understanding of the phylogeny of the ... -
How nonlinear processing shapes natural stimulus encoding in the retina
(2022-05-31)Understanding natural vision is one of the fundamental goals of sensory neuroscience. The only part of the visual system that may currently be amenable to such a complete understanding is the vertebrate retina, where there ... -
Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution
(2009-02-23)Huntington s disease (HD) is a fatal neurodegenerative disorder resulting from an expansion of a polyglutamine stretch in a ubiquitously expressed protein called huntingtin. Intraneuronal ... -
Hydrodynamics of Ciliary Systems
(2023-08-15)The interactions of cilia with one another and their environment are central to many important questions in biology. These hairlike organelles are found in motile and immotile (or `primary') variants, and have a variety ... -
Identification and Analysis of Gene Product Modifiers of α-Synuclein Toxicity in the Fruit Fly (D. Melanogaster).
(2010-09-22)Parkinson s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by loss of dopaminergic neurons in the substantia nigra pars compacta. Various mutations ... -
Identification and analysis of JAK/STAT pathway target genes in Drosophila melanogaster
(2009-07-30)The JAK/STAT signalling cascade is one of the most conserved pathways in the animal kingdom. Aside from its developmental roles, the JAK/STAT pathway is needed for stem cell maintenance, ... -
Identification and Characterisation of Lipid Droplet-Localised Proteins
(2021-03-16)Lipid droplets (LD) are unique organelles, whose physiological relevance has been underestimated for a long time. Well-known in seed tissues for storing triacylglycerol (TAG) to fuel post-germinative seedling establishment, ... -
Identification and characterization of ADNP as a novel heterochromatin component
(2011-03-29)In eukaryotic cells genetic information in the form of long linear DNA fibers is stored in the cell nucleus. Time and tissue specific gene expression patterns are manifested by the combination ... -
Identification and Characterization of Importin 13 Substrates
(2018-05-09)Nuclear pore complexes embedded in the nuclear envelope regulate the bidirectional transport of macromolecules between the nucleus and the cytoplasm. Small molecules can rapidly move through the permeability barrier of the ... -
Identification and characterization of molecular mechanisms driving the functional specification of motor neurons The Delta like homolog 1 protein
(2012-03-02)Spinal Motor neurons are playing a decisive role in body posture and locomotion by controlling skeletal muscle contraction via their motor axon termini. During embryonic development motor ...