Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 448-467 of 1223
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Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
(2016-09-09)The great diversity of adult morphologies that we can observe in nature is the product of millions of years of evolution of the underlying developmental programs. The genes that code for the transcription factors and ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Identifying stage-specific markers of Alzheimer's disease using quantitative proteomics
(2018-09-13)Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that leads to progressive memory loss and impairment of other cognitive functions. It is the most prevalent form of dementia in the elderly and is estimated ... -
Identifying Target Genes related to Respiratory Network Dysfunction in a Mouse Model for the Rett Syndrome
(2013-02-05)Rett Syndrome is a severe neurological disorder caused by mutations in the X chromosome-linked MECP2 gene, which encodes the transcription factor methyl CpG binding protein 2 (MeCP2). Symptoms become obvious during early ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Imaging Network Alterations in Patients With Genetic Generalized Epilepsy and Their Healthy Siblings Using Magneto- and Electroencephalography
(2022-04-05)Genetic generalized epilepsy (GGE) is a common epilepsy syndrome and represents the largest group of epilepsies suspected to have a complex genetic etiology. Specific time windows for age of onset and various seizure types ... -
Impact of mechanically-regulated auxin transport dynamics on plant morphogenesis
(2021-10-21)Auxin is a major plant growth regulator whose interaction with cell wall properties is central to its role. Efflux carriers of this phytohormone of the PIN-FORMED family (PIN) respond to the mechanical state of the tissue. ... -
Impact of Nitrogen Nutrition and Ectomycorrhizal Interaction on Populus x canescens Xylem Sap Composition and Defense
(2020-10-15)Nitrogen (N) is an essential macro-nutrient for plant growth and development. Inorganic N is taken up by plant roots as ammonium (NH4+) or nitrate (NO3-). Roots of tree species are colonized by mycorrhizal fungi, which ... -
Impact of stroke and enriched environment on visual cortical plasticity in mice and therapeutic interventions for rehabilitation
(2014-02-18)Stroke is a major cause of death and disability in industrialized countries. Cortical plasticity is crucial for recovery and rehabilitation after a stroke. The aims of the study were to investigate the impact of a ... -
Impact of Structure Modification on Cardiomyocyte Functionality
(2020-05-28)Cardiac diseases are often related to defects in subcellular components of the heart’s main constituents, the heart muscle cells also called cardiac myocytes. These biological cells periodically contract due to ... -
Implementation of chemical protein-nucleic acid cross-linking into mass spectrometric workflows and mass spectrometric database searches
(2021-11-22)Protein nucleic acid interactions play a pivotal role in cells, from transcription to translation. Functions of proteins in protein nucleic acid interactions are diverse: histones are responsible for the packaging of the ... -
Import of Presequence-Containing Precursor Proteins into Mitochondria
(2014-07-07)The presequence pathway is utilized by over 70% of all cytosolically translated proteins destined to the mitochondria, emphasizing the significance imparted by presequence import on mitochondria translocation. Presequence ... -
Import of proteins along the presequence pathway
(2017-12-01)The aim of this study was to investigate the mechanism of protein transport by the presequence translocase (TIM23) in the inner mitochondrial membrane. Presequencecontaining proteins are imported through the translocase ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ... -
In vitro and in vivo characterization of the E3 ubiquitin ligase RNF157 in the brain
(2015-04-20)From early neurogenesis to the maintenance of post-mitotic neurons, apoptosis plays a pivotal role. Uncontrolled apoptotic events can lead to abnormal neuronal cell loss, which is a hallmark of various neurodegenerative ... -
In Vitro and In Vivo Studies on Antibodies - N-terminally Truncated Abeta in the 5XFAD Mouse Model
(2015-05-29)Commonly used transgenic mouse models mimic Alzheimer´s disease (AD) to some extent but do as well display differences compared to the human AD phenotype. Growing evidence indicates that N-terminally truncated isoforms, ... -
In vitro investigation of trans SNARE complexes arrested between artificial membranes
(2015-09-23)The key components of the machinery that catalyzes membrane fusion include membrane-associated small proteins that are termed as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Calcium-triggered ... -
In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
Inducing Neuroplastic Changes in the Human Cortex using External Transcranial Electrical Stimulation Techniques
(2011-05-13)External transcranial stimulation tools have been widely used to investigate processes of neuroplastic induction and their underlying mechanisms in the intact human cortex. With the development ... -
Influence of Flow and Spatial Heterogeneities on Pattern Formation of Dictyostelium discoideum
(2019-05-24)In the present cumulative thesis the reaction-diffusion equations modeling the signaling process of the social amoeba Dictyostelium discoideum were studied. The pattern formation process in this organism, corresponding to ...