Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 461-480 of 1269
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Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV)
(2024-07-23)Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ... -
Identification of novel components involved in selective and unselective autophagic pathways
(2012-04-11)Autophagy is a ubiquitous protein degradation pathway in eukaryotic cells. As response upon nutrient starvation, cytosolic material and also whole organelles are engulfed by a double membrane-layered vesicle, the ... -
Identification of novel rate-limiting components in Arabidopsis cell entry control against non-adapted fungal pathogens
(2024-09-27)Cell entry into host cells represents a crucial step during pathogenesis of fungal phytopathogens. However, plants have evolved an effective cell entry control mechanism to block a majority of intruders at the front line. ... -
Identification of nuclear export signals and structural analysis of transport complexes.
(2013-01-09)The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and ... -
Identification of peptide-RNA heteroconjugates by mass spectrometry
(2020-10-12)Proteins and nucleic acids are two of the major constituents of life and their interplay is at the center of most biological processes. A deep understanding of the interaction between these biomolecules is crucial for ... -
Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
(2016-09-09)The great diversity of adult morphologies that we can observe in nature is the product of millions of years of evolution of the underlying developmental programs. The genes that code for the transcription factors and ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Identifying stage-specific markers of Alzheimer's disease using quantitative proteomics
(2018-09-13)Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that leads to progressive memory loss and impairment of other cognitive functions. It is the most prevalent form of dementia in the elderly and is estimated ... -
Identifying Target Genes related to Respiratory Network Dysfunction in a Mouse Model for the Rett Syndrome
(2013-02-05)Rett Syndrome is a severe neurological disorder caused by mutations in the X chromosome-linked MECP2 gene, which encodes the transcription factor methyl CpG binding protein 2 (MeCP2). Symptoms become obvious during early ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Imaging Network Alterations in Patients With Genetic Generalized Epilepsy and Their Healthy Siblings Using Magneto- and Electroencephalography
(2022-04-05)Genetic generalized epilepsy (GGE) is a common epilepsy syndrome and represents the largest group of epilepsies suspected to have a complex genetic etiology. Specific time windows for age of onset and various seizure types ... -
Immortalized Primate Granulosa Cell Lines and Pluripotent Stem Cell-Derived Early Germ Cells: Towards Ovarian Follicles In Vitro
(2025-10-24)Access to primate ovarian tissue and mature oocytes is extremely limited, yet these resources are crucial for advancing both infertility treatment and fundamental research in reproductive biology. Conventional sources are ... -
Impact of mechanically-regulated auxin transport dynamics on plant morphogenesis
(2021-10-21)Auxin is a major plant growth regulator whose interaction with cell wall properties is central to its role. Efflux carriers of this phytohormone of the PIN-FORMED family (PIN) respond to the mechanical state of the tissue. ... -
Impact of Nitrogen Nutrition and Ectomycorrhizal Interaction on Populus x canescens Xylem Sap Composition and Defense
(2020-10-15)Nitrogen (N) is an essential macro-nutrient for plant growth and development. Inorganic N is taken up by plant roots as ammonium (NH4+) or nitrate (NO3-). Roots of tree species are colonized by mycorrhizal fungi, which ... -
Impact of stroke and enriched environment on visual cortical plasticity in mice and therapeutic interventions for rehabilitation
(2014-02-18)Stroke is a major cause of death and disability in industrialized countries. Cortical plasticity is crucial for recovery and rehabilitation after a stroke. The aims of the study were to investigate the impact of a ... -
Impact of Structure Modification on Cardiomyocyte Functionality
(2020-05-28)Cardiac diseases are often related to defects in subcellular components of the heart’s main constituents, the heart muscle cells also called cardiac myocytes. These biological cells periodically contract due to ... -
Implementation of chemical protein-nucleic acid cross-linking into mass spectrometric workflows and mass spectrometric database searches
(2021-11-22)Protein nucleic acid interactions play a pivotal role in cells, from transcription to translation. Functions of proteins in protein nucleic acid interactions are diverse: histones are responsible for the packaging of the ... -
Import of Presequence-Containing Precursor Proteins into Mitochondria
(2014-07-07)The presequence pathway is utilized by over 70% of all cytosolically translated proteins destined to the mitochondria, emphasizing the significance imparted by presequence import on mitochondria translocation. Presequence ... -
Import of proteins along the presequence pathway
(2017-12-01)The aim of this study was to investigate the mechanism of protein transport by the presequence translocase (TIM23) in the inner mitochondrial membrane. Presequencecontaining proteins are imported through the translocase ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ...