Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 461-480 of 1236
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Impact of Structure Modification on Cardiomyocyte Functionality
(2020-05-28)Cardiac diseases are often related to defects in subcellular components of the heart’s main constituents, the heart muscle cells also called cardiac myocytes. These biological cells periodically contract due to ... -
Implementation of chemical protein-nucleic acid cross-linking into mass spectrometric workflows and mass spectrometric database searches
(2021-11-22)Protein nucleic acid interactions play a pivotal role in cells, from transcription to translation. Functions of proteins in protein nucleic acid interactions are diverse: histones are responsible for the packaging of the ... -
Import of Presequence-Containing Precursor Proteins into Mitochondria
(2014-07-07)The presequence pathway is utilized by over 70% of all cytosolically translated proteins destined to the mitochondria, emphasizing the significance imparted by presequence import on mitochondria translocation. Presequence ... -
Import of proteins along the presequence pathway
(2017-12-01)The aim of this study was to investigate the mechanism of protein transport by the presequence translocase (TIM23) in the inner mitochondrial membrane. Presequencecontaining proteins are imported through the translocase ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ... -
In vitro and in vivo characterization of the E3 ubiquitin ligase RNF157 in the brain
(2015-04-20)From early neurogenesis to the maintenance of post-mitotic neurons, apoptosis plays a pivotal role. Uncontrolled apoptotic events can lead to abnormal neuronal cell loss, which is a hallmark of various neurodegenerative ... -
In Vitro and In Vivo Studies on Antibodies - N-terminally Truncated Abeta in the 5XFAD Mouse Model
(2015-05-29)Commonly used transgenic mouse models mimic Alzheimer´s disease (AD) to some extent but do as well display differences compared to the human AD phenotype. Growing evidence indicates that N-terminally truncated isoforms, ... -
In vitro investigation of trans SNARE complexes arrested between artificial membranes
(2015-09-23)The key components of the machinery that catalyzes membrane fusion include membrane-associated small proteins that are termed as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Calcium-triggered ... -
In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
Inducing Neuroplastic Changes in the Human Cortex using External Transcranial Electrical Stimulation Techniques
(2011-05-13)External transcranial stimulation tools have been widely used to investigate processes of neuroplastic induction and their underlying mechanisms in the intact human cortex. With the development ... -
Inferring spreading dynamics of diseases and in neural networks
(2025-06-11)The rapid advancement in information technology over the past few decades has provided ample computational power and access to diverse data sources. In conjunction with recent inference methods, we can now examine the ... -
Influence of Flow and Spatial Heterogeneities on Pattern Formation of Dictyostelium discoideum
(2019-05-24)In the present cumulative thesis the reaction-diffusion equations modeling the signaling process of the social amoeba Dictyostelium discoideum were studied. The pattern formation process in this organism, corresponding to ... -
Influence of Heterogeneities on Waves of Excitation in the Heart
(2018-08-27)In this document the interplay of a single large heterogeneity in cardiac tissue and the excitation dynamics associated with ventricuar tachycardia is investigated. Methods from non-linear dynamics are used to investigate ... -
Influence of Interictal Epileptiform Activity on Language Networks in Children with Rolandic Epilepsy or Dyslexia
(2024-01-05)Self-limited Epilepsy with Centrotemporal Spikes (SeLECTS) is the most common genetic epilepsy in children. It is characterized by seizures remission in puberty and highly frequent interictal epileptiform discharges (IEDs) ... -
Influence of Ions on the Assembly of Vimentin Intermediate Filaments
(2020-07-10)The human body consists of many different cell types, which all exhibit a cytoskeleton. This cytoskeleton is mainly composed of three different types of protein filaments, as well as cross-linkers and motor proteins. The ... -
Information Processing Analysis in Neural Networks
(2019-06-06)Populations of cortical neurons in the fluctuation-driven regime exhibit an ultrafast population response. Some theoretical studies suggest that passive, morphological features of the axon and dendrites determine the ... -
Information processing in the olfactory system of different amphibian species
(2020-09-29)General similarities of the olfactory system from insects to mammals make it tempting to extrapolate from one species to the other. However, the olfactory system is remarkably adaptive and diversified among animal lineages ... -
Information, Logic, and Inference in the Analysis of Complex Networks
(2023-12-22)This thesis deals with a range of current topics in information theory and statistics. It consists of five distinct contributions: Chapter 2 focuses on the statistics of single-regression Granger causality estimators. ... -
Insertion of an intrinsically disordered domain in VelB supports selective heterodimer formation of fungal velvet domain regulatory proteins in Aspergillus nidulans
(2019-04-10)The fungal specific velvet domain mediates DNA-binding and protein-protein interaction and is structurally similar to the Rel homology domain of the mammalian immune and infection response NF-ᴋB regulator. Homo- and ... -
Insights into membrane binding of PROPPINs and Reconstitution of mammalian autophagic conjugation systems
(2013-06-24)Autophagy is a degradation pathway conserved in eukaryotes. Upon induction of autophagy a double layered membrane is formed de novo and engulfs the cytosolic content. After fusion of the membrane, an autophagosome vesicle ...