Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 491-510 of 1227
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Interplay of the COP9 signalosome deneddylase and the UspA deubiquitinase to coordinate fungal development and secondary metabolism
(2019-05-29)Protein half-life is controlled through the ubiquitin-proteasome system (UPS). Proteins are labeled with ubiquitin chains by E3 cullin RING ligases (CRLs) and then degraded by the 26S proteasome. The COP9 signalosome (CSN) ... -
Intracellular micromechanics of the syncytial Drosophila embryo
(2015-09-28)A developing embryo is a striking and fascinating example of self-organization and collective behavior of biological matter. In the presented work, I investigated the cytoplasmic interior of Drosophila melanogaster ... -
Intracortical mechanisms compensating weakened thalamic input in the hyperexcitable somatosensory cortex of reeler mutant mice.
(2022-01-21)In the severely disorganized reeler primary somatosensory cortex, thalamocortical axons manage to target layer 4-fated neurons. Although the reeler somatosensory cortex maintains proper activation in response to sensory ... -
Intramural Visualization of Scroll Waves in the Heart
(2015-10-09)Despite extensive research, the fundamental biophysical mechanisms underlying severe heart rhythm disorders such as ventricular fibrillation remain poorly understood. Ventricular fibrillation is an acute and highly lethal ... -
Investigating phase separation mechanisms for transcriptional control
(2020-11-13)Transcription of protein-coding genes by RNA polymerase (Pol) II is a highly coordinated process. In metazoan cells, transcription is regulated both at the initiation step by recruitment of the Pol II machinery as well as ... -
Investigating post-translational modifications and novel interaction partners of otoferlin
(2019-10-30)Otoferlin is a large multi-C2-domain protein essential for hearing and fast Ca2+-triggered transmitter release from auditory IHCs. Mutations in the OTOF gene are linked to a form of autosomal recessive non-syndromic hearing ... -
Investigating the Calcium Signaling at Ribbon Synapses
(2010-05-11)Using whole-cell patch-clamp and fast confocal Ca2+ imaging we show that localized Ca2+ influx sites exist at ribbon synapses in mature inner hair cells of the mouse. Spot detection ... -
Investigating the causal effects of oscillations on intrinsic brain activity
(2019-03-04)Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. Combining tACS with functional magnetic resonance imaging (fMRI), we recently showed that tACS applied over the ... -
Investigating the Evolutionary History of Catarrhine Primates using Whole Genome Data
(2025-05-08)The aim of my PhD project is to investigate the evolutionary history and adaptive potential of diverse catarrhine primates using whole genome sequencing data, with a focus on Bale monkey (Chlorocebus djamdjamensis) and ... -
Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning
(2024-07-09)Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ... -
Investigating the neural processes underpinning the production and anticipation of stuttering in Adults who Stutter
(2019-02-04)Stuttering is a disorder of speech production, characterised by physical disturbances that compromise fluency. Persistent developmental stuttering is a speech fluency disorder defined by its symptoms, where the underlying ... -
Investigating the Re-initiation of Segmentation with Temporally Restricted RNAi in Tribolium castaneum
(2020-10-01)Much of the success of arthropods is attributed to their body’s segmentation. Segmentation provides various opportunities for nature to evolve new structures without greatly impacting overall fitness of the animal. Most ... -
Investigating the Ultrastructural Consequences of Aging on Murine Inner Hair Cell Ribbon Synapses
(2024-03-05)The ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are first synapses of the auditory pathway. They mediate the harmonized and tireless neurotransmission needed for continuous sound ... -
Investigation of a putative circuit in the mouse retina
(2024-06-27)Retinal ganglion cells of the vertebrate retina are tuned to detect specific features of the visual scene and effectively decompose it into different channels that are transmitted to and used by the brain to create the ... -
Investigation of brain networks for personalized rTMS in healthy subjects and patients with major depressive disorder: A translational study
(2021-02-19)Depression is a complex psychiatric disorder with emotional dysregulation at its core. The first line of treatment includes cognitive behaviour therapy and pharmacological antidepressants. However, up to one third of ... -
Investigation of DNA in Cell Nuclei by Combined Imaging Techniques
(2021-03-31)Biological cells are the basic structural and functional units of all organisms. There are approximately 60 trillion eukaryotic cells within a human body alone. A common feature among eukaryotic cells is the nucleus, a ... -
Investigation of early assembly of OXPHOS complexes during mitochondrial translation
(2020-12-02)After a long time of coevolution between mitochondria and their eukaryotic host cells, the mitochondrial genome has diverged severely from it’s α- proteobacterial ancestors. Mitochondrial genes have mainly been transferred to ... -
Investigation of Endosomal Recycling of Synaptic Vesicles
(2010-11-05)During communication at chemical synapses, small neurotransmitter-filled synaptic vesicles, housed in the pre-synaptic nerve terminal (bouton), fuse with the plasma membrane (exocytosis) ... -
Investigation of membrane fusion as a function of lateral membrane tension
(2017-09-21)Membrane fusion in native systems occurs on very short time scales and it has been proposed that lateral membrane tension of the presynaptic membrane is substantially increased to facilitate fusion. Proteins of the SNARE ... -
Investigation of Mitochondrial Ribosome Regulators at the Inner Membrane
(2021-09-24)Mitochondrial biogenesis relies on the proper assembly of proteins from dual genetic origin. Nuclear-encoded proteins are imported into the organelle and incorporated into multiprotein complexes together with proteins ...