Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 531-550 of 1174
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Manipulating co-regulators of RUNX2 and SOX9 to enhance the chondrogenic potential of chondrogenic progenitor cells in osteoarthritis
(2020-12-11)Osteoarthritis (OA) is a degenerative disease of the joint leading to the degradation of the articular cartilage. Current therapies cannot halt or reverse the disease, leading to a severe impact on life quality accompanied ... -
Manipulating neuronal communication by using low-intensity repetitive transcranial magnetic stimulation combined with electroencephalogram
(2021-11-18)Repetitive transcranial magnetic stimulation (rTMS) modulates ongoing brain rhythms by activating neuronal structures and evolving different neuronal mechanisms. In the current work, the role of stimulation strength and ... -
Margin learning in spiking neural networks
(2018-11-29)The ability to learn, generalize and reliably detect features embedded in continuous sensory input streams is a crucial function of the central nervous system. Sensory neurons process input from thousands of synapses ... -
Mathematical modeling of the structure and function of inner hair cell ribbon synapses
(2017-02-03)Information about the auditory world enters the mammalian brain through ribbon synapses of inner hair cells. Due to their fundamental role in auditory processing, these nanoscopic structures have recently received a lot ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Maturation of ribbon synapses in hair cells is driven by thyroid hormone
(2007-06-07)Ribbon synapses of inner hair cells (IHCs) undergo developmental maturation until after the onset of hearing. Here, we studied whether IHC synaptogenesis is regulated by thyroid hormone ... -
MDM2 as a chromatin modifier
(2020-09-08)Since its discovery about 40 years ago, the transcription factor p53 has turned into the most extensively studied protein in the context of human cancers due to its essential role in promoting tumor suppression. P53 ... -
Mechanical Properties of the lch5 Organ in the Drosophila Larva
(2017-09-08)I begin with a brief account of the topic of mechanosensation, followed by an outline of how the project evolved. The experimental techniques used and their rationale are described. The section ends with a short description ... -
Mechanics and Dynamics of <i>Dictyostelium discoideum</i> adhesion
(2021-09-28)The amoeba Dictyostelium discoideum (D.d.) is an excellent laboratory model system for studying amoeboid adhesion. In its natural habitat, D.d. lives in the soil and hunts for bacteria, an environment, which ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Mechanics of suspended cells probed by dual optical traps in a confocal microscope
(2015-12-02)Cells are sensitive to mechanical cues from their environment and at the same time generate and transmit forces to their surroundings. In this thesis, we quantitatively measured forces and elastic spring constants of ... -
Mechanism of Germ Cell Specification in Early Zebrafish Embryogenesis
(2021-07-19)Reproduction is an essential feature of life that ensures the perpetuation and survival in many multicellular organisms while passing the genetic information to the next generation. The zebrafish germline is specified ... -
Mechanism of non-canonical ubiquitination by ubiquitin conjugating enzyme Ubc6
(2023-10-18)Protein quality control by ubiquitination occurs due to the sequential action of three enzyme classes: ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligases (E3). Conventionally, ubiquitin (Ub) ... -
Mechanism of regulation of spliceosome activation by Brr2 and Prp8 and links to retinal disease
(2013-11-12)Splicing is a crucial post-transcriptional processing event that entails the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNA and the ligation of the coding sequences (exons). It is carried ... -
Mechanism of Ribosome Rescue by Alternative Release Factor B
(2020-07-09)Rescue of ribosomes stalled on non-stop mRNAs is essential in bacteria and in the mitochondria of all eukaryotes. The lack of a stop codon causes ribosomes to stall at the 3’ end of mRNA with an empty A site, and specialized ... -
Mechanisms of local and global motion detection in Drosophila
(2021-07-06)Visual motion is an essential cue for many sighted animals. This can either be caused by the movement of an object, or the relative movement of the entire world caused by self-motion of the animal. Accordingly, the brain ... -
Mechanisms of Neuroligin Function in Inhibitory Postsynaptic Differentiation
(2009-10-14)The establishment of accurate synaptic transmission underlies neural network processing and nervous system function. The organized deployment of specialized synaptic machinery is a key ... -
Mechanisms of programmed ribosomal -1 frameshifting in bacteria
(2014-07-15)Translation of proteins must be accurate to synthesize functional proteins. However, in some cases gene information is reprogrammed which overwrites the normal decoding rules of translation. One of these cases is programmed ... -
Mechanisms of pronuclear migration in mammalian zygotes
(2019-08-30)In sexually reproducing species, life begins with the fusion of egg and sperm to form the one-cell embryo, called the zygote. Maternal and paternal DNA form the female and male pronuclei, and must migrate to each other to ... -
Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites
(2019-11-19)In eukaryotic cells, inter-organelle communication is crucial for several cellular functions, as well as for several cell signaling mechanisms. Mitochondria and the endoplasmic reticulum (ER), for example, form tight contact ...