Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 61-80 of 1182
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Analysis of autoimmune lesions in grey matter
(2018-06-14)In the present thesis I demonstrated that pathogenic TβSyn cells of wild-type and receptor-transgenic origins could be reliably generated and used for inducing passive transfer EAE; active EAE could be reproducibly induced ... -
Analysis of early steps in Assembly of Cytochrome c Oxidase
(2014-12-18)Cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. Due to its multimeric nature, assembly and maturation requires the concerted action of over 20 assembly factors in yeast. COX is composed of both ... -
Analysis of genetic interactions and hierarchies of Wnt-signaling components in vivo
(2013-02-13)In cooperation with other signaling cascades the Wnt/β-catenin signaling pathway is an essential regulator of embryonic development as well as adult tissue homeostasis and stem cell proliferation. Mutations in components ... -
Analysis of Mdm38 function in mitochondrial translation
(2015-11-05)The data presented in this thesis demonstrate that binding of Mdm38 to ribosomes has conserved characteristics in yeast and E. coli. To gain further insights into potential binding partners, an in vivo photo cross-linking ... -
Analysis of mice deficient in late endosomal SNARE proteins VAMP8/endobrevin and Vti1b
(2007-01-29)Membrane fusion requires a synchronized interplay between several proteins that form the membrane fusion machinery. SNAREs are the central component of this fusion machinery. Cognate SNARE ... -
Analysis of mitochondrial transcription and replication on the single nucleoid level
(2019-03-13)Human mitochondrial DNA (mtDNA) is a circular molecule encoding for 13 subunits of the respiratory chain that are essential for its maintenance. Inside the mitochondria, mtDNA is associated with various proteins, forming ... -
Analysis of multifunctional RNA helicase regulation by protein cofactors in different gene expression processes
(2023-09-11)The biogenesis of ribonucleoprotein (RNP) complexes is a fundamental process in the gene expression network. Assembly of eukaryotic ribosomes and spliceosomes is highly orchestrated and entails the formation of numerous ... -
Analysis of multiprotein-complex components pulled-down with STRIPAK in Sordaria macrospora
(2022-04-14)The striatin-interacting phosphatase and kinase (STRIPAK)-complex is highly conserved and can be found in fungi and animals. In the filamentous ascomycete Sordaria macrospora (Sm), the SmSTRIPAK plays an important role in ... -
Analysis of Protein Transport to the Inner Nuclear Membrane
(2019-07-10)The eukaryotic cell is divided into different compartments. The biggest compartment is the nucleus which is formed by one lipid bilayer folded into two membranes: the outer nuclear membrane (ONM) and the inner nuclear ... -
Analysis of splice-defect associated cardiac diseases using a patient-specific iPSC-cardiomyocyte system
(2021-01-15)The induced pluripotent stem cell (iPSCs) based cardiomyocyte system (iPSC-CMs) is a powerful tool to serve as a human in vitro model for cardiac diseases. Dilated cardiomyopathy (DCM) and left ventricular non-compaction ... -
Analysis of the Interactome and Membrane Insertion of VAPB, a Tail- Anchored Protein at the Inner Nuclear Membrane
(2020-06-26)Tail-anchored (TA) proteins are a group of integral membrane proteins defined by the presence of a single transmembrane domain (TMD) at the C-terminal domain and are involved in functionally diverse cellular processes. ... -
Analysis of the RAB family of GTPases in C. elegans and their role in regulating neuronal membrane trafficking
(2011-05-03)Rab GTPases are master regulators of intracellular trafficking. They are involved in every aspect of membrane transport from vesicle budding to vesicle fusion. Their functions are regulated ... -
Analysis of the regulation of ICS1-independent SAR gene expression by N-hydroxy-pipecolic acid
(2024-10-08)Systemic acquired resistance (SAR) is a plant immune response that ripostes a local pathogen attack. A mobile signal, induced in infected plant cells, travels from these infected tissues to systemic leaves. This prepares ... -
Analysis of the transcriptome of human NK lymphocytes
(2016-10-31)Natural Killer cells are large granular lymphocytes that contribute to both innate and adaptive immunity, as they can not only lyse infected cells or tumors, but also stimulate an adaptive immune response via production ... -
Analysis of the Wnt receptors Ror, Otk and Otk2 during nervous system development in Drosophila melanogaster
(2016-01-20)Wnt signaling regulates many developmental and adult physiological processes. This is achieved through the activation of several distinct Wnt pathways. The outcome is determined by a specific combination of a Wnt ligand ... -
Analysis of translational fidelity in cellular proteins
(2019-03-27)The accuracy of protein biosynthesis determines the quality of the proteome and regulates the fitness of the cell. A comprehensive quantification of miscoding events in the cell is essential to understand the basic mechanisms ... -
Analyzing receptor responses in the Drosophila Johnston's organ with two-photon microscopy
(2017-07-31)Hearing organs rely on force-gated ion channels to convert the mechanical energy imposed by sound into receptor potentials usable by the nervous system. So far, little is known about the identity and working mechanisms of ... -
Arrhythmia termination using Global Optogenetic Stimulation in ChR2 mice hearts
(2021-03-04)Cardiac arrhythmias represent a health threat worldwide that can end in sudden death. Treatments which include electrical shocks, anti-arrhythmic drugs and ablation show various disadvantages such as discomfort for the ... -
Aspergillus fumigatus F-box protein Fbx15 functions are dependent on its nuclear localisation signals and are partially conserved between A. fumigatus and A. nidulans
(2020-09-08)Aspergillus fumigatus is a globally distributed opportunistic filamentous fungal pathogen mainly found in compost and represents the main cause of pulmonary aspergillosis in immunocompromised individuals. Fungal development ... -
Assessment of Epigenetic profile in Alzheimer's disease
(2012-11-30)Alzheimer's disease is caused by multivariate factors with a convergent insult to neuronal integrity leading to cognitive decline and neurodegeneration. To develop an efficient therapeutic strategy for treatment of AD calls ...