Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 673-692 of 1259
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Molecular mechanisms of the human pathogen <i>Candida glabrata</i> involved in the interaction with the host
(2008-01-11)Besides superficial skin and vaginal infections Candida glabrata causes life threatening disseminated candidiasis. C. glabrata is now the second most common cause of systemic Candidiasis ... -
Molecular physiology of signal transmission along the auditory pathway
(2017-12-13)Signal transmission lies at the core of brain function. Understanding how information is transferred from one neuron to the other is the first step toward deciphering not just normal brain processing but the pathology of ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Molecular Physiology of Synaptic Sound Encoding
(2025-04-10)Cochlear inner hair cells (IHCs) of the auditory system form specialised chemical synapses called ribbon synapses with type I spiral ganglion neurons (SGNs). These synapses encode sound information into neural signals for ... -
Molecular physiology of synaptic sound encoding at the first auditory synapse
(2018-03-20)To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. A sophisticated, by far not yet fully ... -
Molecular profiling of presynaptic docking sites
(2011-10-20)In presynaptic nerve endings, exocytosis of synaptic vesicles is restricted to specialized areas of the plasma membrane, called active zones, that are distinguished by electron-dense material. Here synaptic vesicles ... -
Molecular Sizing using Fluorescence Correlation Spectroscopy
(2010-11-04)Size is one of the basic characteristics of any object and especially of molecules. It is directly and independently of other properties related to fundamental physical phenomena, like ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
Molecular Transport in Emulsions
(2015-10-01)It is demonstrated how microfluidic tools are applied to access fundamental information on mass transfer between emulsion droplets, which are inaccessible with classical methods of bulk emulsification. Our studies were ... -
Monitoring dynamics of protein nascent chain on the ribosome using PET-FCS
(2020-06-24)The ribosome synthesizes proteins according to the sequence of the messenger RNA (mRNA) by progressively adding amino acids to the C-terminus of the nascent peptide. For a protein to become fully functional, it has to fold ... -
Monitoring mitochondrial translation with spatial resolution and high throughput strategies
(2023-05-30)Nearly all mitochondrial proteins are encoded in the nuclear genome, synthesized in the cytosol, and imported into mitochondria. However, mitochondria are semi-autonomous and possess their own genome, the mitochondrial DNA ... -
Monitoring the late events of translation initiation in real-time
(2016-10-19)In bacteria, translation initiation is promoted by three initiation factors (IF1, IF2 and IF3) and entails three distinct steps. First, the small ribosomal subunit (30S) recruits the initiation factors, initiator tRNA ... -
Monkey see, monkey touch, monkey do: Influence of visual and tactile input on the fronto-parietal grasping network
(2020-06-12)One of the most common movements we do every day is grasping. Usually we do this with aid of our eyes, but other senses, like our sense of touch, can also assist in the preparation and execution of grasping movements. More ... -
Morphogenesis and Genetic Regulation of the Insect Head
(2016-09-30)Natural selection and the struggle for ecological niches were the driving force for the origin of a tremendous number of animal groups with different body shapes. The segmental organization of insects enhanced their ... -
Morphogenesis Control By Mechanical Stress
(2019-08-29)Morphogenesis of plants and animals often emerges from mechanical moulding and deformations. Yet, how precisely cells as individual mechanical entities can act to shape a tissue reliably and ef- ficiently is still puzzling. ... -
Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
(2020-01-10)Within the mammalian inner ear, sensory inner hair cells (IHCs) of the organ of Corti are required to transduce sound waves into electrical signals. Specialized synapses at the IHC basal pole, so-called ribbon synapses, ... -
Motion encoding in the salamander retina
(2016-10-20)The detection and correct interpretation of motion in visual scenes is important in everyday tasks, e.g., for avoiding cars when crossing the street or for assessing the optic flow, induced by self-motion, when navigating ... -
Motor adaptation under visual feedback uncertainty
(2025-03-07)Our motor system continuously receives sensory feedback from our limbs to control movement. This feedback is crucial for compensating for perturbations that disrupt proper control, a process known as motor adaptation. ... -
Mover affects a subpool of primed synaptic vesicles in the mouse calyx of Held
(2019-10-10)Neuronal communication is a complex process; synapses must be formed, neurotransmitter has to be released at precise time points and it has to be “sensed” by the receiving end of a synapse with an equal accuracy. In this ... -
MS-based quantitative analysis of the CRM1 export pathway and spatial proteomics of the Xenopus laevis oocyte
(2015-09-22)Nuclear export is a vital cellular process, which supplies the cytoplasm with essential biological macromolecules, such as matured tRNAs and ribosomal subunits. This process is carried out by a set of proteins called ...