Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 716-735 of 1277
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Multisensory integration under visual target uncertainty during planning of reaching movements
(2025-02-25)Movements are fundamental to human interaction and everyday function, relying on the integration of multiple sensory inputs for precise planning and execution. However, sensory uncertainty, particularly in the visual domain, ... -
Myelin Membrane Growth and Organization in a Cellular Model System (EN)
(2011-01-19)This thesis addresses the two fundamental questions of myelin biogenesis: how the myelin membrane is extended and how it acquires its specific lateral organization. Myelin is a multilayered ... -
Myelin pruning by microglia during development
(2019-04-26)Myelin is a lipid rich membrane produced by oligodendrocytes in the central nervous system. During development, oligodendrocyte precursor cells find their target axons and start to wrap their processes around axons, thereby ... -
Myeloid cell-specific ablation of the mineralocorticoid receptor attenuates experimental autoimmune encephalomyelitis
(2013-02-12)The mineralocorticoid receptor (MR) plays an essential role in regulating fluid and electrolyte homeostasis. Amongst hematopoietic cells, also macrophages express the MR but, unlike kidney or colon, they do not co-express ... -
Myoelectric Signal Processing for Prosthesis Control
(2015-02-03)The myoelectric signal (MES) is the electrical manifestation of contraction. The MES, recorded at the surface of the skin, has been exploited as a control source for powered upper limb prosthetics. The primary objective ... -
N-truncated Aβ4-x peptides in Alzheimer's disease: generation, degradation, and relationship with neuropathological hallmarks
(2021-12-20)Amyloid pathology in Alzheimer’s disease (AD) is characterized by a heterogeneity of amyloid-β peptides (Aβ) variants. The N-terminally truncated Aβ4-42 peptides are among the most abundant species and were reported having ... -
Nanobodies as new tools for studying large cargo transport and lamina organization
(2018-06-26)Nanobodies are the smallest recombinantly expressed antibody fragments, which show outstanding performance in numerous applications. In this work, we set out to generate nanobodies as tools to study nucleo-cytoplasmic ... -
Nanoscale Brownian Dynamics of Semiflexible Biopolymers
(2020-07-24)Proteins are one of, if not the most, versatile of biology’s tools, performing a great variety of functions in living organisms and giving rise to behavior as complex as life itself. They are linear chains of amino acids ... -
Nanoscale organization and dynamics of SNARE proteins in the presynaptic membranes
(2015-10-19)The specific organization of proteins and lipids in functional domains in biological membranes allows localization and segregation of specific physiological activities. Mechanisms that underlie the formation of these domains ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ... -
Nanoscale Photonics
(2017-08-14)Detecting single nanometre scale objects and studying them in a controlled manner in solution is still a difficult task due to diffusion. We demonstrate one-dimensional nanofluidic flows of single molecules by confining ... -
Nanoscale probing of single synapse function and BDNF Cell-to-Cell transfer
(2016-12-22)Brain-derived neurotrophic factor (BDNF) is one of the key modulator/mediator molecules for synaptic plasticity in the adult nervous system and also coordinates neural development, survival, differentiation and axon growth ... -
Nanoscopy inside living brain slices
(2014-10-30)In order to understand how memory is processed and stored in the brain, it would be helpful to observe the ongoing memory processes in action. This is no easy task, however, if it is to be done at the synaptic level. It ... -
NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity
(2014-03-31)The work presented in this thesis is centered on characterizing macroscopic electrophysiological instabilities observed at the tissue level that emanate from perturbations affecting essentially the NaV1.5 channel in the ... -
Network Dynamics as an Inverse Problem
(2016-12-16)In this thesis, we take a general view on the study of networks from inverse perspectives. By proposing a general representation for the dynamics of networks in terms of explicit dependencies among units, we develop new ... -
Network Formation and Dynamics under Economic Constraints
(2018-03-26)Networks describe a broad range of systems across a wide variety of topics from social and economic interactions over technical infrastructures such as power grids and the internet to biological contexts such as food webs ... -
Network formation and reorganization of the olfactory system of Xenopus laevis
(2022-03-03)The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
"Eine neue Rolle für Myelin-assoziierte Inhibitoren für die Mobilität von Mikroglia"
(2009-05-28)In the central nervous system of mammals, the regeneration of axons after injury is limited. The reduced ability of neurite outgrowth can be attributed, in part, to the presence of inhibitor proteins enriched in myelin. ... -
Neural basis of rule-based decisions with graded choice biases
(2016-07-22)In every hour of every day we are faced with options; which route to take to work, where to go for a meal, which stocks to invest in. However, with limitations of movement, time and budget, our options are constrained. We ...