Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 739-758 of 1198
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On the mechanisms governing plasma membrane organization - a STED-FCS investigation
(2014-06-04)The plasma membrane is the barrier which localizes and separates life's processes from their external environment. Long described as a free standing two-dimensional fluid mosaic, the organization of the plasma ... -
On the molecular basis of α-synuclein aggregation on phospholipid membranes in the presence and absence of anle138b
(2020-07-22)A physiologic hallmark of synucleinopathies such as Parkinson’s Disease (PD) or Multiple System Atrophy (MSA) are deposits in patients’ brains, which consist of the α-synuclein. Growing evidence suggests, that oligomeric ... -
On the putative role of Pelota in stem cell differentiation
(2010-04-20)In this work we analyzed the role of pelota in the conditional knockout mouse model. We shed light on its function during development and report the defects resulting from Pelota depletion. ... -
On the Scales of Turbulent Motion at High Reynolds Numbers
(2015-12-08)Turbulence is a physical state of a fluid far from equilibrium. In turbulent flows, a huge number of degrees of freedom is excited and a wide range of interacting scales determines the flow characteristics. Turbulent ... -
On the Speed of Neuronal Populations
(2017-10-10)This thesis presents novel results in the areas of closed loop electrophysiology and neuronal population coding. This work begins by presenting the first known attempt to control the spike rate of a neuron or neurons using ... -
On the Use of Temporal Information for the Reconstruction of Magnetic Resonance Image Series
(2020-10-28)Standard clinical magnetic resonance imaging uses data sampled at the Nyquist rate which limits it to frame rates of 1-4 frames per second. Over the past decade different methods for the reconstruction of images from ... -
On Turbulent Rayleigh-Bénard Convection in a Two-Phase Binary Gas Mixture
(2015-11-27)In this thesis an attempt is made to generate cloud patterns in a laboratory scale experiment. A two-phase binary gas mixture is employed as a physical model system. The fluid mixture is composed of a condensable gas which ... -
Onset and Progression of Neurodegeneration in Mouse Models for Defective Endocytosis
(2019-10-25)Neurodegenerative diseases have become an increasing problem in our aging society. Many studies have addressed these complex diseases in the recent years. Scientists have learned a lot about specific proteins, their ... -
Optical Analysis of Synaptic Plasticity Underlying Associative Learning in Drosophila melanogaster
(2018-10-10)Learning and memory is a prerequisite for the survival and the appropriate adaptation of behavioral responses in an ever-changing environment. Memories are formed, stored, and retrieved in the brains of animals. The formation ... -
Optical analysis of synaptic vesicle protein molecules during exo- and endocytosis using pH-switchable fluorescent probes
(2011-11-22)At conventional synapses of the central nervous system (CNS), fast synaptic transmission is mediated by the release of neurotransmitters (NTs) upon Ca2+-triggered synaptic vesicle (SV) ... -
Optical bionanosensors for neurotransmitter detection
(2018-10-17)Information transfer in the human brain is enabled by neurotransmitters - messenger molecules that diffuse between cells. Static concentration measurements are useful to identify molecules involved in neurotransmission, ... -
Optimal navigation in active matter
(2023-07-11)Motile active matter systems are composed of a collection of agents, each of which extracts energy from the surrounding environment in order to convert it into self-driven motion. At the microscopic scale, however, directed ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ... -
Optimization of tools for multiplexed super resolution imaging of the synapse
(2020-07-09)The synapse is the major site of neurotransmission in the brain. Even though the synapse has been extensively studied, artefact-free imaging tools are still necessary for its correct investigation. With the resolution of ... -
Optimization principles and constraints shaping visual cortical architecture
(2012-05-03)Neurons in the mammalian primary visual cortex (V1) are often preferentially driven by only one of the two eyes and respond best to oriented bar stimuli at a particular position in the visual field. Most carnivorans and ... -
Optimizing the efficacy of transcranial direct current stimulation on cortical neuroplasticity based on a neurovascular coupling model
(2017-03-01)Transcranial direct current stimulation (tDCS) induces polarity-specific enduring alterations of cortical excitability, and activity. Cortical excitability can be monitored in a limited set of cortical areas in the human ... -
Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ... -
Order under the guise of chaos: functional neuroanatomy of the somatosensory "barrel" cortex of the reeler mutant mouse
(2016-05-13)Rodents possess an array of facial whiskers on either side of their snout, which they use to collect tactile information about their surroundings. In layer IV of the somatosensory cortex, individual whiskers are represented ... -
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ... -
Orientation and organization of the presynaptic active zone protein Bassoon: from the Golgi to the synapse
(2016-08-30)Neurotransmitter release sites at the presynaptic terminus membrane, known as the active zones (AZs), are surrounded by synaptic vesicle pools and a dense network of five cytomatrix of the active zone (CAZ) proteins. At ...