Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 75-94 of 1199
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Analysis of the transcriptome of human NK lymphocytes
(2016-10-31)Natural Killer cells are large granular lymphocytes that contribute to both innate and adaptive immunity, as they can not only lyse infected cells or tumors, but also stimulate an adaptive immune response via production ... -
Analysis of the Wnt receptors Ror, Otk and Otk2 during nervous system development in Drosophila melanogaster
(2016-01-20)Wnt signaling regulates many developmental and adult physiological processes. This is achieved through the activation of several distinct Wnt pathways. The outcome is determined by a specific combination of a Wnt ligand ... -
Analysis of translational fidelity in cellular proteins
(2019-03-27)The accuracy of protein biosynthesis determines the quality of the proteome and regulates the fitness of the cell. A comprehensive quantification of miscoding events in the cell is essential to understand the basic mechanisms ... -
Analyzing receptor responses in the Drosophila Johnston's organ with two-photon microscopy
(2017-07-31)Hearing organs rely on force-gated ion channels to convert the mechanical energy imposed by sound into receptor potentials usable by the nervous system. So far, little is known about the identity and working mechanisms of ... -
Arrhythmia termination using Global Optogenetic Stimulation in ChR2 mice hearts
(2021-03-04)Cardiac arrhythmias represent a health threat worldwide that can end in sudden death. Treatments which include electrical shocks, anti-arrhythmic drugs and ablation show various disadvantages such as discomfort for the ... -
Aspergillus fumigatus F-box protein Fbx15 functions are dependent on its nuclear localisation signals and are partially conserved between A. fumigatus and A. nidulans
(2020-09-08)Aspergillus fumigatus is a globally distributed opportunistic filamentous fungal pathogen mainly found in compost and represents the main cause of pulmonary aspergillosis in immunocompromised individuals. Fungal development ... -
Assessment of Epigenetic profile in Alzheimer's disease
(2012-11-30)Alzheimer's disease is caused by multivariate factors with a convergent insult to neuronal integrity leading to cognitive decline and neurodegeneration. To develop an efficient therapeutic strategy for treatment of AD calls ... -
Astroglial and therapeutic factors affect demyelination in murine models with toxic demyelination
(2013-04-16)Astrocytes might play an important role in demyelinating diseases such as multiple sclerosis (MS) since serum autoantibodies directed against the astrocytic water channel aquaporin-4 cause inflammatory demyelinating lesions ... -
Astroglial glutamate transporters are essential for maintenance of respiratory activity in the rhythmic slice preparation
(2012-01-25)Astrocytes are the major type of glial cells in the brain and were already described in the 19th century by Rudolf Virchow. The physiological investigation of astrocytes has long been hampered by difficulties to identify ... -
Atg21 functions during autophagy as a scaffold for the E3 ubiquitin-‐like complex in Atg8 lipidation
(2015-01-23)Autophagy summarizes a family of intracellular lysosomal (vacuolar) degradative transport process. It is used for the removal and recycling of cytoplasm, protein aggregates and organelles to maintain cellular homeostasis. ... -
Atg21 restricts Atg8 lipidation to a novel vacuole-phagophore contact site
(2019-07-01)Macroautophagy is a degradative membrane trafficking pathway that removes and recycles cellular components to maintain cellular homeostasis. Targets for degradation are a variety of cytosolic components including protein ... -
Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A
(2016-01-22)Macroautophagy is a conserved catabolic pathway for the removal and recycling of cytosolic components, damaged or surplus organelles, protein aggregates or intracellular pathogens to maintain cellular homeostasis. It is ... -
Attention modulation of complex motion patterns in human visual cortex
(2014-12-12)When we are moving through the environment, our visual system exposes to a barrage of motion information about the objects around us as well as our own heading. Processing such an amount of incoming sensory data is beyond ... -
Attention: A Complex System
(2015-12-21)Experiments have elucidated the neuronal correlates of attention in the primate brain, and have led to a number of models capturing various aspects of these experiments. However, these model propose qualitatively different ... -
Attenuated apoptosis as consequence of Epithelial Mesenchymal Transition
(2014-08-14)The developmental program of Epithelial Mesenchymal Transition (EMT) is assumed to be involved in tumor progression, enabling cancer cells to spread from the primary tumor and form metastasis in distant tissues. At least ... -
Auditory associative learning and its neural correlates in the auditory midbrain
(2021-01-08)Interpreting the meaning of environmental stimuli to generate optimal behavioral responses is essential for survival. Simply sensing a sound, without accessing prior knowledge in the brain, will not benefit behavior. How ... -
Auditory descending neurons in the prothoracic network of the bush cricket Ancistrura nigrovittata
(2024-06-20)Ancistrura nigrovittata is a duetting phaneropterine bush cricket species. Males sing with a fixed temporal and spectral pattern, the characteristics of which are important for recognition; females reply to the song with ... -
Auditory nerve function in mouse models of ATP11A and CABP1-CABP2 related hearing loss
(2025-02-10)Hearing loss can be caused by varied factors affecting diverse structures of the auditory system such as the middle ear, the stria vascularis, the outer hair cells (OHC), inner hair cells (IHC), the spiral ganglion neurons ... -
Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis
(2015-03-17)Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ... -
Automated STED microscopy for cell-biological high-throughput assays
(2022-11-28)In the past decade, super-resolution fluorescence microscopy has revolutionized biological research by enabling the study of biological functions down to the molecular scale. Despite profound technological developments, ...