Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 751-770 of 1263
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New sample preparation techniques of macromolecular complexes for high resolution structure determination using cryo-EM
(2020-04-07)Fatty acids are one of the most abundant lipids in the cell. Cells use them to build biological membranes, as energy reserves and as signaling molecules. Fatty acids are synthesized by a specialized protein machinery called ... -
NFATc1 driven ER-stress responses in the progression of non-alcoholic fatty liver disease
(2021-06-30)Non-alcoholic fatty liver disease (NAFLD) mirrors the hepatic manifestation of the metabolic syndrome and is defined by progressive fat accumulation in hepatocytes (steatosis). Uncomplicated NAFLD may progress to a severe ... -
NMR Spectroscopy of the Tau-Microtubule Interaction
(2015-12-10)Tau is an intrinsically disordered, microtubule associated protein and is responsible for the promotion of microtubule (MT) formation and stabilization. The human Tau protein has six different isoforms, which are expressed ... -
Non-Canonical Amino Acids as Minimal Tags for Investigating Protein Organization and Turnover
(2016-01-08)The burgeoning field of genetic code expansion provides new tools for specifically labeling proteins for a variety of applications. Clickable non-canonical amino acids (ncAA) have been refined for almost-quantitative and ... -
Non-canonical functions of the MDM2 oncoprotein
(2022-11-04)The tumour suppressor gene TP53 is mutated in ~50% of human cancers. The p53 protein is a transcription factor which is induced by several cellular stresses, such as ribosomal stress and DNA damage. Expression of its target ... -
Non-equilibrium Statistical Mechanics Studied Through the Lens of Stochastic Calculus
(2024-01-11)The microscopic world of atoms and molecules is continuously in motion, which is manifested on the macroscopic scale as a non-zero temperature. Due to collisions with surrounding molecules that perform thermal motion, many ... -
Nonequilibrium Statistical Mechanics
(2020-03-27)Active matter is everywhere, from macroscopic to microscopic scales, we find systems such as human crowd or flock of birds as well as bacterial colonies. These systems composed of particles are able to convert their ... -
Nonlinearities in bipolar cells and their role for encoding visual signals
(2019-05-02)Vision begins in the retina, where ganglion cells separate the visual input into ~30 parallel output channels with different response characteristics to visual stimuli. How retinal ganglion cells obtain such a diversity ... -
Norepinephrine induces internalization of Kv1.1 in hippocampal neurons
(2017-08-08)Norepinephrine (NE), a catecholamine produced by dopamine β-hydroxylase, is released either as a hormone from the adrenal medulla into the blood, or as a neurotransmitter in the brain. Norepinephrine signaling serves as a ... -
Novel Applications of Super-Resolution Microscopy in Molecular Biology and Medical Diagnostics
(2016-03-31)Despite recent advances in microscopy techniques, the underlying labeling assays remained mostly unchanged. However, super-resolution techniques require other staining conditions than conventional light microscopy, like ... -
Novel approach for identification of biocatalysts by reverse omics techniques
(2019-08-06)A novel screening approach for identification of biocatalysts by reverse omics techniques was developed. Basic principle is the differential analysis of metatranscriptomes obtained from cultures treated either with the ... -
Novel approaches to measure physiological and behavioral responses to stress
(2020-02-21)Stress is the perception of threats to one's physical or psychological integrity, leading to certain autonomous, affective, and behavioral responses. Albeit its important role in adapting to new contexts and thus increasing ... -
Novel design and data analysis concepts for MINFLUX nanoscopy
(2021-11-22)MINFLUX is a novel concept for super-resolution fluorescence microscopy that achieves unprecedented image resolution despite the limited photon budget of fluorescent molecules. The goal of this thesis is to improve MINFLUX ... -
Novel export and import pathways in S. cerevisiae identified by an engineered SUMO system
(2018-09-07)Nuclear transport receptors (NTRs) mediate the translocation of cargos between the cytoplasm and the nucleus. NTRs are classified either as importins or exportins according to the directionality of the cargo transport. To ... -
Novel production system for influenza A virus-derived defective interfering particles and analysis of antiviral activity
(2020-09-24)Influenza A virus (IAV) increases morbidity and mortality rates and novel antivirals are needed to combat the virus. Errors of the viral polymerase lead to the generation of defective RNAs. These DI-RNAs may interfere with ... -
Novel roles of Celf1 and Tia1 during vegetal RNA localization in Xenopus laevis oocytes
(2015-10-29)The localization of certain mRNAs to the vegetal cortex of Xenopus oocytes is of crucial importance for germ cell development and germ layer formation of the future embryo. Vegetal RNA localization is mediated by signal ... -
Nuclear export of actin: A biochemical and structural perspective
(2015-08-18)Macromolecular exchange between the nucleus and the cytoplasm is mainly mediated by the RanGTP-dependent nuclear transport receptors (NTRs) of the Impβ family. NTRs are classified as importins and exportins according to ... -
Nuclear mRNA quality control factors Gbp2 and Hrb1 take part in cytoplasmic mRNA surveillance through nonsense-mediated decay
(2022-01-27)Yeast SR-like proteins Gbp2 and Hrb1 shuttle between the nucleus and the cytoplasm, and serve as quality control factors for pre-mRNA splicing. They are loaded onto the RNA co-transcriptionally, and upon correct splicing, ... -
Nuclear transport of the nitric oxide synthase interacting protein (NOSIP)
(2023-05-23)Proteins that need to actively enter the nucleus are thought to be transported by a specific nuclear transport receptor (NTR), depending on the type of the nuclear localization signal (NLS). Some cargoes are reported to ... -
Nucleation of Chemically Active Droplets
(2024-09-10)The interior of a cell is a complicated mixture of many components, and dynamics need to be orchestrated in time and space to ensure the proper functioning of the cell. One key strategy for achieving this tight control is ...