Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 756-775 of 1213
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Optical Analysis of Synaptic Plasticity Underlying Associative Learning in Drosophila melanogaster
(2018-10-10)Learning and memory is a prerequisite for the survival and the appropriate adaptation of behavioral responses in an ever-changing environment. Memories are formed, stored, and retrieved in the brains of animals. The formation ... -
Optical analysis of synaptic vesicle protein molecules during exo- and endocytosis using pH-switchable fluorescent probes
(2011-11-22)At conventional synapses of the central nervous system (CNS), fast synaptic transmission is mediated by the release of neurotransmitters (NTs) upon Ca2+-triggered synaptic vesicle (SV) ... -
Optical bionanosensors for neurotransmitter detection
(2018-10-17)Information transfer in the human brain is enabled by neurotransmitters - messenger molecules that diffuse between cells. Static concentration measurements are useful to identify molecules involved in neurotransmission, ... -
Optimal navigation in active matter
(2023-07-11)Motile active matter systems are composed of a collection of agents, each of which extracts energy from the surrounding environment in order to convert it into self-driven motion. At the microscopic scale, however, directed ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ... -
Optimization of tools for multiplexed super resolution imaging of the synapse
(2020-07-09)The synapse is the major site of neurotransmission in the brain. Even though the synapse has been extensively studied, artefact-free imaging tools are still necessary for its correct investigation. With the resolution of ... -
Optimization principles and constraints shaping visual cortical architecture
(2012-05-03)Neurons in the mammalian primary visual cortex (V1) are often preferentially driven by only one of the two eyes and respond best to oriented bar stimuli at a particular position in the visual field. Most carnivorans and ... -
Optimizing the efficacy of transcranial direct current stimulation on cortical neuroplasticity based on a neurovascular coupling model
(2017-03-01)Transcranial direct current stimulation (tDCS) induces polarity-specific enduring alterations of cortical excitability, and activity. Cortical excitability can be monitored in a limited set of cortical areas in the human ... -
Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ... -
Order under the guise of chaos: functional neuroanatomy of the somatosensory "barrel" cortex of the reeler mutant mouse
(2016-05-13)Rodents possess an array of facial whiskers on either side of their snout, which they use to collect tactile information about their surroundings. In layer IV of the somatosensory cortex, individual whiskers are represented ... -
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ... -
Orientation and organization of the presynaptic active zone protein Bassoon: from the Golgi to the synapse
(2016-08-30)Neurotransmitter release sites at the presynaptic terminus membrane, known as the active zones (AZs), are surrounded by synaptic vesicle pools and a dense network of five cytomatrix of the active zone (CAZ) proteins. At ... -
Oscillations in routing and chaos
(2017-10-09)The human brain is one of the most complex structures known to mankind, and arguably the most elaborate biological system that ever evolved. Studying such complex machinery whose precision and efficiency we witness in the ... -
Oscillatory instabilities of intracellular fiber networks
(2015-12-02)D. discoideum shares many common features of actin dynamics and essential responses with eukaryotic cells and cancer cells. Therefore, most properties of the oscillations are well studied in the simpler biological model ... -
Pair-correlation effects in many-body systems
(2023-05-25)The laws of nature encompass the small, the large, the few, and the many. In this thesis we are concerned with classical (i.e. not quantum) many-body systems, which refers to any microscopic or macroscopic system that ... -
Pairing transcranial direct current stimulation and mindfulness meditation in the treatment of fibromyalgia
(2024-08-22)The lack of effective treatments for managing pain and associated symptoms in fibromyalgia (FM) poses both a clinical challenge and an economic burden on the health sector. Typical FM therapies include an array of ... -
Pancreatic β-Cell Regeneration in TIF-IA Knockout Mice
(2014-09-30)As the sole source of insulin production in body, pancreatic β-cells play an essential role in glucose homeostasis. Diabetes mellitus is a chronic disease characterized by loss, reduction, and/or malfunction of β-cell mass. ... -
Paramagnetic Tagging of Oligonucleotides for Structure Determination using NMR-Spectroscopy
(2015-03-31)Structure determination is one of the most fundamental fields of research, as it provides insights in biological systems and their mechanisms. Therein, NMR spectroscopy is an essential tool for investigations under ... -
Paramagnetic tools for the structural analysis of high molecular weight proteins
(2015-12-10)Paramagnetic effects provide important structural and dynamic information of biomolecules. However, the attachment of lanthanides through small chelating organic molecules to proteins (the most common way to obtain ... -
Pathogen-induced cell wall remodeling and production of Danger Associated Molecular Patterns (DAMPs)
(2020-08-25)For a plant pathogen, overcoming the plant cell wall is crucial for a successful infection. Thus, pathogens evolved different strategies to invade their host plants. These include entry through natural openings such as ...