Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 759-778 of 1263
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Norepinephrine induces internalization of Kv1.1 in hippocampal neurons
(2017-08-08)Norepinephrine (NE), a catecholamine produced by dopamine β-hydroxylase, is released either as a hormone from the adrenal medulla into the blood, or as a neurotransmitter in the brain. Norepinephrine signaling serves as a ... -
Novel Applications of Super-Resolution Microscopy in Molecular Biology and Medical Diagnostics
(2016-03-31)Despite recent advances in microscopy techniques, the underlying labeling assays remained mostly unchanged. However, super-resolution techniques require other staining conditions than conventional light microscopy, like ... -
Novel approach for identification of biocatalysts by reverse omics techniques
(2019-08-06)A novel screening approach for identification of biocatalysts by reverse omics techniques was developed. Basic principle is the differential analysis of metatranscriptomes obtained from cultures treated either with the ... -
Novel approaches to measure physiological and behavioral responses to stress
(2020-02-21)Stress is the perception of threats to one's physical or psychological integrity, leading to certain autonomous, affective, and behavioral responses. Albeit its important role in adapting to new contexts and thus increasing ... -
Novel design and data analysis concepts for MINFLUX nanoscopy
(2021-11-22)MINFLUX is a novel concept for super-resolution fluorescence microscopy that achieves unprecedented image resolution despite the limited photon budget of fluorescent molecules. The goal of this thesis is to improve MINFLUX ... -
Novel export and import pathways in S. cerevisiae identified by an engineered SUMO system
(2018-09-07)Nuclear transport receptors (NTRs) mediate the translocation of cargos between the cytoplasm and the nucleus. NTRs are classified either as importins or exportins according to the directionality of the cargo transport. To ... -
Novel production system for influenza A virus-derived defective interfering particles and analysis of antiviral activity
(2020-09-24)Influenza A virus (IAV) increases morbidity and mortality rates and novel antivirals are needed to combat the virus. Errors of the viral polymerase lead to the generation of defective RNAs. These DI-RNAs may interfere with ... -
Novel roles of Celf1 and Tia1 during vegetal RNA localization in Xenopus laevis oocytes
(2015-10-29)The localization of certain mRNAs to the vegetal cortex of Xenopus oocytes is of crucial importance for germ cell development and germ layer formation of the future embryo. Vegetal RNA localization is mediated by signal ... -
Nuclear export of actin: A biochemical and structural perspective
(2015-08-18)Macromolecular exchange between the nucleus and the cytoplasm is mainly mediated by the RanGTP-dependent nuclear transport receptors (NTRs) of the Impβ family. NTRs are classified as importins and exportins according to ... -
Nuclear mRNA quality control factors Gbp2 and Hrb1 take part in cytoplasmic mRNA surveillance through nonsense-mediated decay
(2022-01-27)Yeast SR-like proteins Gbp2 and Hrb1 shuttle between the nucleus and the cytoplasm, and serve as quality control factors for pre-mRNA splicing. They are loaded onto the RNA co-transcriptionally, and upon correct splicing, ... -
Nuclear transport of the nitric oxide synthase interacting protein (NOSIP)
(2023-05-23)Proteins that need to actively enter the nucleus are thought to be transported by a specific nuclear transport receptor (NTR), depending on the type of the nuclear localization signal (NLS). Some cargoes are reported to ... -
Nucleation of Chemically Active Droplets
(2024-09-10)The interior of a cell is a complicated mixture of many components, and dynamics need to be orchestrated in time and space to ensure the proper functioning of the cell. One key strategy for achieving this tight control is ... -
Nucleoporin-binding nanobodies that either track or trap uclear pore complex assembly
(2021-03-25)Nuclear pore complexes (NPCs) are large multi-protein assemblies that control the transport of macromolecules between the nucleus and the cytoplasm. Their formation from ~ 1,000 individual polypeptides is an impressive ... -
Nucleosylaminosäuren als Bausteine zur Synthese modifizierter Oligonucleotide
(2014-05-13)It has been proposed that biopolymers need to be uniformly charged to form self-sustaining chemical systems. We have therefore established a method for the site-selective replacement of natural phosphodiester linkages of ... -
Numerical Simulations on the Biophysical Foundations of the Neuronal Extracellular Space
(2013-11-25)The electric activity of neurons creates extracellular potential fields. Recent findings show that these endogenous fields act back onto the neurons, contributing to synchronization of population activity. The influence ... -
Olfactory Perception and Physiology in Drosophila melanogaster
(2013-05-22)All animals are able to evaluate an odor by its consequences depending on prior experiences. This includes the possibility to show a resembling response to similar odors with the same consequence as well as a distinct ... -
On Control of the Excitable Dynamics in the Heart
(2019-11-19)Ventricular fibrillation, a frequent cause of death, is a heart condition associated with complex patterns of electric activity on the heart surface. In spite of a century of research many aspects of how ventricular ... -
On mass transport in Physarum polycephalum
(2019-12-20)The network-forming slime mold Physarum polycephalum has proven to be the epitome of self-organization. As a single cell it adapts seemingly intelligent to stimuli, integrating various inputs to create a coordinated response ... -
On the Effect of Binding on Ubiquitin Dynamics
(2014-03-26)Protein-protein interactions play an important role in all biological processes. But the principles underlying these interactions are not yet fully understood. Ubiquitin is a small signalling protein that non-covalently ... -
On the mechanisms governing plasma membrane organization - a STED-FCS investigation
(2014-06-04)The plasma membrane is the barrier which localizes and separates life's processes from their external environment. Long described as a free standing two-dimensional fluid mosaic, the organization of the plasma ...