Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 779-798 of 1198
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Pharmacotreatment of a mouse model of Rett syndrome with the radical scavenger Trolox: Detailed assessment of potential merits in vitro and in vivo
(2015-04-27)Rett syndrome is a severe neurodevelopmental disorder, with an incidence of ~1/1000 female births, in which most patients carry mutations in the methyl-CpG binding protein 2 gene. No cure exists so far. Rett girls are born ... -
Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ... -
Phenotype-based genetic association studies in schizophrenia: Proof-of-principle for cognition-relevant genes.
(2011-05-02)Schizophrenia is the collective term for a heterogeneous group of mental disorders with a still obscure biological basis. In particular, the specific contribution of risk or candidate gene ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Phosphoketolase - A mechanistic update
(2018-08-22)The thiamine diphosphate (ThDP)-dependent enzyme phosphoketolase catalyzes the phosphorolytic cleavage of fructose-6-phosphate and/or xylulose 5-phosphate under the generation of the high-energy metabolite acetyl phosphate, ... -
Phospholamban – Characterization of the Potential Interaction Partner SLMAP
(2024-10-10)The identification of novel PLN interaction partners is of high importance to understand how it is regulated on a molecular level and to develop new therapeutic strategies for cardiomyopathy. SLMAP, a novel putative PLN ... -
Phosphorylation of Synaptotagmin 4 captures transiting dense core vesicles at active synapses
(2017-03-03)Synaptic modulation requires fast recruitment of neuronal dense core vesicles (DCVs) containing various neuropeptides and neurotrophins at nerve terminals. DCVs undergo long-range trafficking in axons to deliver cargoes ... -
Phylogenetic studies of the vesicular fusion machinery
(2010-10-01)The eukaryotic cell consists of a large system of membrane delimited compartments. Material exchange between these compartments is mediated by intracellular trafficking vesicles. These ... -
Physiological Classification of Retinal Ganglion Cells in the Salamander Retina
(2016-04-13)The retina is a complex neural network, responsible for breaking down the visual scene into its distinctive features such as local contrast, motion and color. The retinal ganglion cells form the output layer of this ... -
Physiological functions of the adrenocortical circadian clock
(2014-09-10)In the course of evolution most organisms have evolved endogenous circadian clocks that help them to anticipate daily environmental changes in light, temperature and food availability and therefore adjust physiology and ... -
Plasma Factors as Endogenous Agonists and Modulators of TLR4 Signaling in Microglia
(2010-06-30)Toll-like receptors (TLRs) comprise a family of pattern recognition receptors (PRRs) which recognize pathogen-associated molecular patterns (PAMPs) an assortment of evolutionary conserved ... -
Plasticity of Dopamine-Releasing Central Brain Neurons Underlying Adaptational Feeding-Related Behavior in Drosophila Melanogaster
(2020-05-07)All organisms have to adapt and adjust behaviors to changing environmental conditions. Foraging and feeding behaviors are one of the most adaptive behaviors when changes in nutrient sources occur. Neuronal and behavioral ... -
Plasticity-dependent modulation of mitochondrial biogenesis determining motor neuron function and vulnerability
(2016-10-10)Axon terminals are likely the compartments of highest energy demand in the particularly active and polarized cells that are motor neurons. Paradoxically, although the particularly high-energy demand of motor neurons could ... -
Pore-spanning lipid membranes as a tool to study membrane permeabilization by antimicrobial peptides
(2017-09-06)Antimicrobial peptides (AMPs) have a high therapeutic potential in combating microbial diseases. Their modes of action are still not well understood, and screening methods to identify and improve AMPs are needed. This work ... -
Pore-spanning membranes – a versatile tool to analyze SNARE-mediated single vesicle fusion
(2018-06-27)Signal transmission in neurons and hormone secretion in neuroendocrine cells such as chromaffin cells are fundamental biological processes including SNARE- (soluble N-ethylmaleimide-sensitive-factor attachment receptor) ... -
Post-Translational Protein Modifications involved in Exo- and Endocytosis of Synaptic Vesicles
(2021-10-26)Neurotransmitter release is a key step that enables information flow between the pre- and post-synapse. However, regulation of the neurotransmitter release remains an intricate and widely unexplored matter despite recent ... -
Preclinical evaluation of nanoparticle enhanced breast cancer diagnosis and radiation therapy
(2021-07-09)Triple negative breast cancer (TNBC) is an aggressive type of cancer which makes up 15-20% of all newly diagnosed cases, lacking the main target molecules for tumor specific treatment. Surgery or systemic therapy by ... -
Precursors of epi-/shamixanthone formed in Hülle cells cause oxidative stress sensitivity and repress sexual development of the filamentous fungus Aspergillus nidulans
(2020-02-06)Fungal secondary metabolites are small molecular products that are not directly involved in survival but play a role as a reaction to environmental changes including multiple chemical structures and bioactivities. Fungal ... -
Prenatal maternal stress effects in wild Assamese macaques (Macaca assamensis)
(2022-11-22)Across mammals, adverse conditions experienced during specific ontogenetic sensitive periods can have persisting effects on neurodevelopment, acquisition of cognitive and motoric skills, immune function, and systemic ... -
Preparation and investigation of an in vitro model system for the GABAA receptor organisation machinery of inhibitory post synapses
(2020-07-22)The synaptic communication between neuronal cells is based on the release and uptake of neurotransmitters. In the mammalian brain inhibitory signal transduction relies on the neurotransmitter γ-amino butyric acid (GABA) ...