Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 809-828 of 1214
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Proactive planning of action sequences
(2024-07-05)Everyday tasks often require a sequence of actions. Knowing which actions will follow, allows us to proactively prepare for subsequent actions before the first action has been executed. This thesis investigated the neural ... -
Probing Molecular Stoichiometry by Photon Antibunching and Nanofluidics Assisted Imaging in Solution
(2017-07-05)A mechanistic understanding of biological function requires a quantitative determination of macromolecular subunit architecture and interaction. Optical microscopy and spectroscopy provide a noninvasive method to characterize ... -
Probing roles of TRPML in Drosophila hearing
(2016-01-15)Several transient receptor potential (TRP) channels have been implicated in Drosophila hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA members Pyx and Pain. Here I report that fly hearing ... -
Probing the function of Ca2+-binding C2 domains of otoferlin, a synaptic protein of sensory hair cells
(2024-11-05)The ribbon synapses in auditory inner hair cells (IHCs) are specialized to achieve indefatigable sound encoding at rates of hundreds of Hertz and with sub-millisecond temporal precision. While conventional synapses employ ... -
Processing of different sensory qualities in the olfactory bulb of Xenopus laevis studied by advanced line illumination microscopy
(2016-10-10)The olfactory system is renowned for its ability to sample and process a tremendously large odorant space. Lately, it has been shown that other sensory qualities such as temperature and pressure are detected in the ... -
Processing of Graded Signaling Systems
(2016-03-24)Vocal repertoires of nonhuman animals and especially of terrestrial mammals are often characterized by their relatively small size of innate vocal types which can show considerable variation in acoustic structure. To ... -
Programmed Translational Readthrough in Drosophila melanogaster
(2020-06-05)Translational readthrough (TR) is extensively used by viruses to expand their limited genome capacity. The pervasiveness of TR across eukaryotic genomes is only recently being explored. Systems biology approaches such as ... -
Protein Interactions in minimal cells
(2022-05-18)Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ... -
Protein Structure Characterization by Solid-State NMR: Structural Comparison of Mouse and Human alpha-Synuclein Fibrils, Sparse 13C Labeling Schemes, and Stereospecific Assignment of Val and Leu Prochiral Methyl Groups
(2013-04-10)This thesis describes protein structure characterization by solid-state nuclear magnetic resonance (ssNMR), including structural investigation of mouse alpha-synuclein (maS) fibrils and the comparison to human apha-synuclein ... -
Protein Turnover on Plant Lipid Droplets
(2020-04-30)Lipid droplets (LDs) are lipid storage organelles found across all kingdoms of life. In recent years, the perception of the organelle has shifted from inactive lipid storage sites to dynamic organelles central to the ... -
Proteomic Profiles of Campylobacter jejuni and Enterococci during Co-incubation and under Bile Acid Stress
(2023-11-03)The human gut harbors a complex ecosystem of microbial communities, consisting of commensal inhabitants, which play crucial roles in maintaining gut homeostasis, regulating host metabolism, and modulating immune responses. ... -
Proteomics of Aspergillus nidulans sexually differentiated cells
(2018-10-01)The homothallic mold Aspergillus nidulans produces as overwintering structures closed sexual fruiting bodies named cleistothecia, which contain ascospores as products of meiosis. Formation of fruiting bodies is linked to ... -
Protonation patterns in reduced and oxidized form of electron transfer proteins
(2012-10-23)The pKa's of the ionizable amino acids are crucial for the function of many proteins as they are key factors that determine their electrostatic potential and its spatial distribution, often controlling and optimizing ... -
Proximity and Affinity based Analysis of Cardiac Caveolin Protein Interactions
(2020-03-06)Background and Objectives: The Caveolin (CAV1-3) family contains a unique class of membrane integral proteins with cytosolic termini. CAV1 or CAV3 are essential components of the caveolar core complex, a disc-shaped ... -
PTK7 protein localization and stability is affected by canonical Wnt ligands
(2016-02-04)Wnt co-receptors have been shown to be endocytosed in response to Wnt proteins. However, the role of Wnt receptor internalization for Wnt signaling is a topic of ongoing research. Here we show that the Wnt co-receptor PTK7 ... -
PUCK: Primer Utilised CRISPR/Cas Knock-Ins for High Throughput Super-Resolution Microscopy
(2024-11-29)The insertion of tags into proteins via gene editing is a powerful tool for microscopy, enabling the comparative analysis of different proteins. The advent of CRISPR/Cas systems has greatly simplified gene editing and ... -
Pulvinar-cortical interactions for spatial perception and goal-directed actions in non-human primates
(2018-12-12)The pulvinar nucleus, the largest thalamic nucleus in primates, has been shown to be involved in goal-directed visuomotor behavior related to the contralateral side of visual space. However, there is conflicting evidence ... -
Purification of organellar macromolecular complexes for structural biology
(2022-03-14)Photosynthesis is the source of life on Earth. In oxygenic photosynthesis, water and carbon dioxide are converted into organic matter using of solar energy that results in the release of oxygen. PSII, a supra-molecular ... -
Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Quantifying Evolutionary Dynamics
(2015-06-04)Adaptation is a central process in evolution: populations adapt to their environment by accumulating beneficial mutations over the course of generations. Microbial populations present an excellent experimental system that ...