Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 809-828 of 1263
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Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Pathway and network analyses in context of Wnt signaling in breast cancer
(2016-03-01)A complex network of interplaying signaling pathways governs cell behavior and phenotype. Wnt signaling pathways are part of this network and play an important role in embryonic development as well as in carcinogenesis. ... -
Pathways for phospholipid deacylation in Saccharomyces cerevisiae and their impact on fatty acid trafficking and equilibrium
(2011-01-25)The phospholipid (PL) class and species composition is a fundamental characteristic of membranes, essential to their proper function. The PL species distribution of cellular lipids is only ... -
Perception of visual motion speed in human und monkey
(2007-06-27)Perception of motion is crucial for the survival of most animals, as well as of humans. It has been shown that a number of stimulus factors can influence the visual perception of motion ... -
Perceptual and motor intentional processing in dorsal pulvinar
(2019-06-27)The pulvinar is the largest thalamic structure in the center of the brain, reciprocally connected to a large diversity of cortical areas. It has grown more than other subcortical structures during primate evolution, which ... -
Perceptual Misbinding of Color and Motion - Visual Feature Integration in Humans and Macaques
(2025-02-24)To interact with our environment, sensory signals must be translated into perceptions that guide our behavior. However, our noisy, crowded, and dynamic environment provides too much information to process. As a result, our ... -
Peripheral nervous system control for neuroprostheses
(2017-09-21)Amputee patients who have lost a hand or arm are severely impaired in their daily life, as they lose the ability to grasp and interact with their environment. While the use of electromyographically controlled prosthetic ... -
Perturbation Growth and Prediction of Extreme Events
(2018-11-15)Extreme events occur in a variety of dynamical systems. Here we employ quantifiers of chaos to identify changes in the dynamical structure of complex systems preceding an extreme event. -
Perturbation of Pattern Formation in Dictyostelium Discoideum via Flow and Spatial Heterogeneities
(2020-04-07)In this thesis, we investigate the signalling process of the social amoeba Dictyostelium discoideum (D. discoideum) as a model reaction-diffusion-advection system. Colonies of these cells are an excitable medium that ... -
Pharmacological alterations of neuroplasticity in the human motor cortex induced by dopaminergic and cholinergic agents
(2011-03-03)Dopamine and Acetylcholine are the major neuromodulators in the human central nervous system which strongly influence neuroplasticity. Several factors including subreceptor specificity, ... -
Pharmacologically controlled neurotrophic factor gene therapy for Parkinson's disease
(2019-07-24)During the PhD thesis, two projects were carried out. In the first project, an inducible AAV-5 vector for expression of GDNF, under control of the approved small molecule drug mifepristone, was evaluated in rats. GDNF ... -
Pharmacotherapeutic approaches against Plasmodium falciparum
(2025-06-23)Malaria tropica persists as one of the most impactful infectious diseases, threatening the health of nearly half of the world’s population every year. The disease is caused by Plasmodium falciparum (P. falciparum), a ... -
Pharmacotreatment of a mouse model of Rett syndrome with the radical scavenger Trolox: Detailed assessment of potential merits in vitro and in vivo
(2015-04-27)Rett syndrome is a severe neurodevelopmental disorder, with an incidence of ~1/1000 female births, in which most patients carry mutations in the methyl-CpG binding protein 2 gene. No cure exists so far. Rett girls are born ... -
Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ... -
Phenotype-based genetic association studies in schizophrenia: Proof-of-principle for cognition-relevant genes.
(2011-05-02)Schizophrenia is the collective term for a heterogeneous group of mental disorders with a still obscure biological basis. In particular, the specific contribution of risk or candidate gene ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Phosphoketolase - A mechanistic update
(2018-08-22)The thiamine diphosphate (ThDP)-dependent enzyme phosphoketolase catalyzes the phosphorolytic cleavage of fructose-6-phosphate and/or xylulose 5-phosphate under the generation of the high-energy metabolite acetyl phosphate, ... -
Phospholamban – Characterization of the Potential Interaction Partner SLMAP
(2024-10-10)The identification of novel PLN interaction partners is of high importance to understand how it is regulated on a molecular level and to develop new therapeutic strategies for cardiomyopathy. SLMAP, a novel putative PLN ... -
Phosphorylation of Synaptotagmin 4 captures transiting dense core vesicles at active synapses
(2017-03-03)Synaptic modulation requires fast recruitment of neuronal dense core vesicles (DCVs) containing various neuropeptides and neurotrophins at nerve terminals. DCVs undergo long-range trafficking in axons to deliver cargoes ... -
Phylogenetic studies of the vesicular fusion machinery
(2010-10-01)The eukaryotic cell consists of a large system of membrane delimited compartments. Material exchange between these compartments is mediated by intracellular trafficking vesicles. These ...