Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 826-845 of 1228
-
Protein Interactions in minimal cells
(2022-05-18)Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ... -
Protein Mobility in the Complex Physical Environment of the Synapse
(2025-05-22)Robust signal transmission between cells is vital for our daily lives. It relies on fine orchestration of many processes, particularly taking place at chemical synapses. Here, chemical reactions occur in precise order, ... -
Protein Structure Characterization by Solid-State NMR: Structural Comparison of Mouse and Human alpha-Synuclein Fibrils, Sparse 13C Labeling Schemes, and Stereospecific Assignment of Val and Leu Prochiral Methyl Groups
(2013-04-10)This thesis describes protein structure characterization by solid-state nuclear magnetic resonance (ssNMR), including structural investigation of mouse alpha-synuclein (maS) fibrils and the comparison to human apha-synuclein ... -
Protein Turnover on Plant Lipid Droplets
(2020-04-30)Lipid droplets (LDs) are lipid storage organelles found across all kingdoms of life. In recent years, the perception of the organelle has shifted from inactive lipid storage sites to dynamic organelles central to the ... -
Proteomic Profiles of Campylobacter jejuni and Enterococci during Co-incubation and under Bile Acid Stress
(2023-11-03)The human gut harbors a complex ecosystem of microbial communities, consisting of commensal inhabitants, which play crucial roles in maintaining gut homeostasis, regulating host metabolism, and modulating immune responses. ... -
Proteomics of Aspergillus nidulans sexually differentiated cells
(2018-10-01)The homothallic mold Aspergillus nidulans produces as overwintering structures closed sexual fruiting bodies named cleistothecia, which contain ascospores as products of meiosis. Formation of fruiting bodies is linked to ... -
Protonation patterns in reduced and oxidized form of electron transfer proteins
(2012-10-23)The pKa's of the ionizable amino acids are crucial for the function of many proteins as they are key factors that determine their electrostatic potential and its spatial distribution, often controlling and optimizing ... -
Proximity and Affinity based Analysis of Cardiac Caveolin Protein Interactions
(2020-03-06)Background and Objectives: The Caveolin (CAV1-3) family contains a unique class of membrane integral proteins with cytosolic termini. CAV1 or CAV3 are essential components of the caveolar core complex, a disc-shaped ... -
PTK7 protein localization and stability is affected by canonical Wnt ligands
(2016-02-04)Wnt co-receptors have been shown to be endocytosed in response to Wnt proteins. However, the role of Wnt receptor internalization for Wnt signaling is a topic of ongoing research. Here we show that the Wnt co-receptor PTK7 ... -
PUCK: Primer Utilised CRISPR/Cas Knock-Ins for High Throughput Super-Resolution Microscopy
(2024-11-29)The insertion of tags into proteins via gene editing is a powerful tool for microscopy, enabling the comparative analysis of different proteins. The advent of CRISPR/Cas systems has greatly simplified gene editing and ... -
Pulvinar-cortical interactions for spatial perception and goal-directed actions in non-human primates
(2018-12-12)The pulvinar nucleus, the largest thalamic nucleus in primates, has been shown to be involved in goal-directed visuomotor behavior related to the contralateral side of visual space. However, there is conflicting evidence ... -
Purification of organellar macromolecular complexes for structural biology
(2022-03-14)Photosynthesis is the source of life on Earth. In oxygenic photosynthesis, water and carbon dioxide are converted into organic matter using of solar energy that results in the release of oxygen. PSII, a supra-molecular ... -
Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Quantifying Evolutionary Dynamics
(2015-06-04)Adaptation is a central process in evolution: populations adapt to their environment by accumulating beneficial mutations over the course of generations. Microbial populations present an excellent experimental system that ... -
Quantifying the diffusion of membrane proteins and peptides
(2013-08-15)Lipid and protein diffusion in membranes is a fundamental requirement for many signaling processes in biological cells. Therefore, measuring protein and lipid mobility in lipid bilayers with high accuracy is essential for ... -
Quantifying topological transformation in lipid self-assemblies
(2021-06-03)Surfactant assemblies are characterized by soft intermolecular interactions and can be deformed or topologically altered by thermal or mechanical stress of the magnitude of thermal fluctuations. In biology, the protein ... -
Quantitation Strategies in Optically Sectioning Fluorescence Microscopy
(2009-06-15)The development of microscopes that can record fluorescence intensity in five and more dimensions in one experiment (e.g. space, time and colour) makes parameters available for the scientific ... -
Quantitative analysis of Förster resonance energy transfer from spectrally resolved fluorescence measurements
(2010-08-25)A novel method for spectral analysis of Forster resonance energy transfer (FRET) signals is presented. This method provides a general solution for donor quenching and acceptor sensitization ... -
Quantitative Modeling of RNA-Protein Interactions
(2021-05-07)RNA-binding proteins (RBPs) impact every aspect of RNA metabolism including RNA transcription, maturation, export, localization, translation, and stability. Specific RNA-protein interactions therefore play a central role ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ...