Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 838-857 of 1182
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Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
Regulation of clade I TGA transcription factors of Arabidopsis thaliana during salicylic acid-mediated defense response
(2020-07-31)TGA1 and TGA4 belong to a family of basic leucine zipper transcription factors. They are important activators of salicylic acid (SA) biosynthesis upon pathogen infection (Sun et al. 2018). Moreover, they interact with a ... -
Regulation of H2B Monoubiquitination Pathway in Breast cancer
(2015-01-23)H2B monoubiquitination (H2Bub1) regulation via CDK9-WAC-RNF20/40 axis has been well illustrated. It is interesting to determine the upstream regulators which dictate the process of monoubiquitination of H2B. On further ... -
Regulation of human 48S initiation complex formation
(2024-04-23)During the initiation phase of protein synthesis in humans, the small ribosome subunit interacts with initiator tRNA (tRNAi) and at least ten different initiation factors (eIFs) to form the initiation complex. The initiation ... -
Regulation of Permeation in Aquaporins
(2016-02-19)Regulation of water permeation is an essential aspect of homeostasis in living organisms. Proteins of the ubiquitous aquaporin family act as trans-membrane tetrameric channels through which water may permeate under osmotic ... -
Regulation of plant stress responses by clade I TGA transcription factors and interacting CC-type glutaredoxins
(2023-11-09)TGACG-BINDING (TGA) transcription factors are important regulators in numerous processes such as pathogen defense, development and detoxification. To control some of these responses, plant specific CC type glutaredoxins ... -
Regulation of recycling endosomal membrane traffic by a γ-BAR/ kinesin KIF5 complex
(2008-01-15)Intracellular trafficking of membrane proteins and lipids between different compartments is a fundamental process underlying a variety of cell physiological functions of eukaryotic cells. ... -
Regulation Of Spindle Orientation By A Mitotic Actin Pathway In Chromosomally Unstable Cancer Cells
(2020-11-18)Aneuploidy is a hallmark of human cancer and is observed in 90 % of solid tumors. The perpetual gain or loss of whole chromosomes, defined as chromosomal instability (CIN), represent one mechanism causing aneuploidy. CIN ... -
Regulation of the homeoprotein Hesx1 via Mad2l2 and the anaphase promoting complex
(2008-09-17)Understanding the functional significance of the coordinate expression and interaction of homeobox transcription factors remains a critical question in developmental biology. Hesx1 is a ... -
Regulation of the Hrd1 Ubiquitin ligase during protein degradation at the endoplasmic reticulum
(2024-05-16)Misfolded or redundant proteins of the endoplasmic reticulum are degraded via ER associated degradation: They are recognized, undergo a retrotranslocation into the cytosol, become ubiquitinated, are extracted from the ... -
Regulation of the neuronal SNARE-complex by accessory proteins
(2018-02-16)In this work, I have thoroughly characterized a novel complex containing syntaxin1a (1-288), SNAP25a and Munc18-1 and established it as an efficient acceptor complex for synaptobrevin-binding, using several biochemical and ... -
Regulation of vesicular trafficking in presence of mutations in contractile proteins
(2022-06-20)The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ... -
Regulatory interactions of enzymes of the citric acid cycle in Bacillus subtilis
(2013-01-25)In most organisms the tricarboxylic acid (TCA) cycle is a fundamental hub in metabolism. The TCA cycle is the origin and the endpoint of a broad spectrum of intermediates and provides the cell with energy and cellular ... -
Release of a Natural mRNA During Recycling of the Prokaryotic Ribosome
(2023-06-20)Ribosome recycling is the last step of the bacterial translation cycle. The release of the peptide leaves a 70S ribosome with a deacylated tRNA in the P site and the stop codon of the mRNA in the A site. The combined action ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Representation of individual finger movements in macaque areas AIP, F5 and M1
(2019-05-21)The goal of this study was to investigate how individuated finger movements are coded in area AIP, F5 and M1. At the single neuron level, most of the units in all three areas were “broadly tuned”, responding during multiple ... -
Requirements for pre-catalytic B complex formation during exon- and intron-defined spliceosome assembly
(2015-10-07)In eukaryotes, most protein-coding genes are interrupted by non-coding sequences known as introns. The splicing of intronic sequences from a pre-mRNA is catalyzed by the spliceosome, an elaborate molecular machine formed ... -
Residue level characterization of molecular interactions of intermembrane space domains governing the preprotein import into the mitochondrial matrix
(2014-12-10)Mitochondrial matrix targeting proteins are translated as preproteins (carrying an N-terminal 20-50 residue presequence) in the cytoplasm. Post-translationally, they are imported into the mitochondrial matrix through ... -
RESOLFT nanoscopy with water-soluble synthetic fluorophores
(2018-01-17)Fluorescence microscopy is an important and widely used tool in the life sciences due to its unique ability to observe cellular processes in living specimens with target-specific image contrast. The development of high ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ...