Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 849-868 of 1213
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Reconstitution of Doa10-mediated ER-associated protein degradation with purified components
(2020-11-09)ER-associated protein degradation (ERAD) is a protein quality control pathway at the ER membrane mediated by membrane-embedded ubiquitin ligase complexes. During ERAD, membrane and luminal proteins are ubiquitinated and ... -
Reconstitution of retrotranslocation by the Hrd1 ubiquitin ligase with purified components
(2020-03-11)In eukaryotic organisms, a large fraction of newly-synthesized proteins are destined for the endomembrane system or for secretion. The entry gate for these proteins is the endoplasmic reticulum (ER). Proteins are imported ... -
Reconstructing the electrical dynamics on the heart
(2022-11-09)The heart is an electro-mechanical system. In 2010 about 4.25 million people died from cardiac arrhythmias. Immediate treatment in case of fibrillation is to shock the heart electrically with high energy to reset the ... -
Reconstruction of Cardiac Wave Dynamics from Mechanical Deformation
(2024-05-24)Cardiac arrhythmias, such as atrial and ventricular fibrillation, are caused by abnormal electrical activity within the heart muscle, leading to irregular contractions and potentially life-threatening situations. Current ... -
Recycling as a mechanism for extracellular matrix remodeling at the synapse
(2021-12-10)In the adult brain, the extracellular matrix (ECM) forms lattices that sheath neurons and synapses. The exceptional longevity of ECM molecules lends these lattices a unique durability, and as such, they are deemed to ... -
Redox imbalance and oxidative stress in Mecp2 deficient neurons
(2016-11-10)Rett syndrome is a neurodevelopmental disorder that primarily occurs in girls with a prevalence of 1:10.000–1:15.000 life births. The main genetic reasons of Rett syndrome are mutations in the methyl-CpG binding protein 2 ... -
Reference frames for planning reach movement in the parietal and premotor cortices
(2016-02-16)Human and nonhuman primates are able to plan and execute goal-directed behavior and flexibly respond to their surrounding stimuli. Their ability to adapt to changes in their environment is a crucial factor for their ... -
Regulation des intrazellulären Transports durch UNC-50 und die GARP-Komplexes in C. elegans
(2010-12-02)Fast synaptic transmission at the neuromuscular junctions (NMJs) in C. elegans is mediated by the neurotransmitter acetylcholine which activates ligand-gated ion channels of the nicotinic ... -
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
Regulation of clade I TGA transcription factors of Arabidopsis thaliana during salicylic acid-mediated defense response
(2020-07-31)TGA1 and TGA4 belong to a family of basic leucine zipper transcription factors. They are important activators of salicylic acid (SA) biosynthesis upon pathogen infection (Sun et al. 2018). Moreover, they interact with a ... -
Regulation of H2B Monoubiquitination Pathway in Breast cancer
(2015-01-23)H2B monoubiquitination (H2Bub1) regulation via CDK9-WAC-RNF20/40 axis has been well illustrated. It is interesting to determine the upstream regulators which dictate the process of monoubiquitination of H2B. On further ... -
Regulation of human 48S initiation complex formation
(2024-04-23)During the initiation phase of protein synthesis in humans, the small ribosome subunit interacts with initiator tRNA (tRNAi) and at least ten different initiation factors (eIFs) to form the initiation complex. The initiation ... -
Regulation of Permeation in Aquaporins
(2016-02-19)Regulation of water permeation is an essential aspect of homeostasis in living organisms. Proteins of the ubiquitous aquaporin family act as trans-membrane tetrameric channels through which water may permeate under osmotic ... -
Regulation of plant stress responses by clade I TGA transcription factors and interacting CC-type glutaredoxins
(2023-11-09)TGACG-BINDING (TGA) transcription factors are important regulators in numerous processes such as pathogen defense, development and detoxification. To control some of these responses, plant specific CC type glutaredoxins ... -
Regulation of recycling endosomal membrane traffic by a γ-BAR/ kinesin KIF5 complex
(2008-01-15)Intracellular trafficking of membrane proteins and lipids between different compartments is a fundamental process underlying a variety of cell physiological functions of eukaryotic cells. ... -
Regulation Of Spindle Orientation By A Mitotic Actin Pathway In Chromosomally Unstable Cancer Cells
(2020-11-18)Aneuploidy is a hallmark of human cancer and is observed in 90 % of solid tumors. The perpetual gain or loss of whole chromosomes, defined as chromosomal instability (CIN), represent one mechanism causing aneuploidy. CIN ... -
Regulation of the homeoprotein Hesx1 via Mad2l2 and the anaphase promoting complex
(2008-09-17)Understanding the functional significance of the coordinate expression and interaction of homeobox transcription factors remains a critical question in developmental biology. Hesx1 is a ... -
Regulation of the Hrd1 Ubiquitin ligase during protein degradation at the endoplasmic reticulum
(2024-05-16)Misfolded or redundant proteins of the endoplasmic reticulum are degraded via ER associated degradation: They are recognized, undergo a retrotranslocation into the cytosol, become ubiquitinated, are extracted from the ... -
Regulation of the neuronal SNARE-complex by accessory proteins
(2018-02-16)In this work, I have thoroughly characterized a novel complex containing syntaxin1a (1-288), SNAP25a and Munc18-1 and established it as an efficient acceptor complex for synaptobrevin-binding, using several biochemical and ... -
Regulation of vesicular trafficking in presence of mutations in contractile proteins
(2022-06-20)The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ...