Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 878-897 of 1182
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Role of microglia in myelin turnover
(2016-07-11)During development oligodendrocytes in the central nervous system (CNS) produce large amount of membrane to generate myelin which wraps around the axons. The synthesis, maintenance and turnover of such enormous amounts of ... -
Role of Munc13 Isoforms in Regulating Large Dense Core Vesicle Exocytosis in Chromaffin Cells
(2015-11-03)The process of vesicular exocytosis is a fast, tightly regulated and Ca2+-triggered event mediated by SNARE complex formation. Although it is known that factors like Munc18, Munc13 and CAPS are important in setting up ... -
Role of Neuroligins at the Inhibitory Postsynaptic Compartment of the Retina
(2010-06-15)Neuroligins are postsynaptic cell adhesion proteins central to synapse maturation and function.There are four isoforms of Neuroligins (1 4) expressed in the rodent brain. Neuroligins 1 and ... -
Role of predisposing genetics, telomere signaling and crosstalk of cardiac fibroblasts and cardiomyocytes in a pluripotent stem cell model of dilated cardiomyopathy
(2023-02-16)Despite rapid scientific and medical advances, cardiovascular diseases represent a major threat to human health worldwide. Among these, cardiomyopathies are one of the leading causes of heart failure. Dilated cardiomyopathy ... -
Role of prion protein in synucleinopathies
(2020-06-11)Synucleinopathies comprise a group of neurodegenerative diseases, characterized by deposits of aggregated alpha-synuclein (aSyn) in neurons and glia. The special hallmark is the presence of Lewy bodies and Lewy neuritis, ... -
Role of PSD-95 in synaptic maturation and visual cortex plasticity
(2014-08-29)PSD-95 belongs to the family of DLG-MAGUKs (Discs-large membrane-associated guanylate kinases), and it plays an important role in organizing postsynaptic signaling and synaptic transmission in excitatory synapses. The ... -
Role of Rho GTPases During Primordial Germ Cell Migration in Zebrafish
(2008-11-26)Cell migration is an essential biological process during development, adult homeostasis, and disease. Actin cytoskeleton plays crucial role in generating forces required for cell migration. ... -
Role of Serine hydroxymethyltransferase in cell cycle control and early Drosophila development
(2016-10-10)The early development of Drosophila melanogaster occurs in a syncytium, where nuclei undergo mitotic divisions without accompanying cytokinesis. Early cleavage cycles are very short and consist only of S and M phases. In ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
Role of the nuclear lamina for stem cell mediated homeostasis
(2016-11-22)The nuclear lamina is a protein meshwork at the inner side of the inner nuclear membrane and connects to essential cellular structures like chromatin, the nuclear pore complex and the cytoskeleton. The nuclear lamina is ... -
Role of WRB protein in cardiac function
(2017-08-24)The mammalian TRC40 system is a conserved pathway responsible for the post-translational targeting of tail-anchored proteins, which are characterized by a single transmembrane domain at the C-terminus and an N-terminus ... -
Roles of miR-137 in Muscular Dystrophy and Muscular Dystrophy-Related Phenotypes in Drosophila melanogaster
(2019-05-07)Muscular dystrophies (MDs) are a group of diseases that cause muscular and neurological disorders in human patients. They are associated with a multi-component complex called the Dystrophin Glycoprotein Complex (DGC). The ... -
Roles of PSD-93 and environmental enrichment in cortical synapses
(2015-11-10)During neurodevelopment several structural, molecular and functional changes take place in the brain to promote its maturation. These changes occur at multiple levels, including changes in protein expression, in the strength ... -
Roles of the HECT-Type Ubiquitin E3 Ligases of the Nedd4 and WWP Subfamilies in Neuronal Development
(2015-05-21)Protein ubiquitination is a core regulatory principle in neuronal development. In this study, I used brain specific KO mice to investigate the roles of several HECT-type Nedd4 superfamily E3 ligases, i.e. Nedd4-1, Nedd4-2, ... -
Roles of the Nedd4 Family E3 Ligases in Glial Function and Nerve Cell Development
(2017-05-09)Protein ubiquitination is one of the core regulatory post-translational modification in neuronal development. In this study, we used brain specific KO mice to identify novel substrate proteins of several Nedd4 family E3 ... -
Roles of α-neurexins in synapse stabilization and Ca<sup>2+</sup>-dependent endocrine secretion
(2007-04-27)α-Neurexins are synaptic cell-surface molecules that are required for neurotransmitter release at synapses. Deletion of multiple α-neurexin genes in mice leads to premature lethality of ... -
Salicylic Acid (SA)-independent processes in Systemic Acquired Resistance (SAR)
(2021-03-25)SAR is an immune response that is established in the systemic leaves after infection of local leaves with biotrophic or hemibiotrophic pathogens. According to the current model, the amino acid-derived metabolite ... -
Saynpatic mechanisms of noise-induced hearing loss
(2024-04-19)Noise-induced hearing loss (NIHL) is a form of acquired hearing impairment, caused by exposure to loud noise, that damages the delicate inner ear structures, possibly including the neural connections between the Inner Hair ... -
Scale-dependent Response of Fluid Turbulence under Variation of the Large-scale Forcing
(2016-02-03)In this work, an experiment to measure the temporal evolution of energy transfer at different scales in a turbulent flow that was subject to a perturbation of the energy injection is described. Two types of experiments ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ...