Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 898-917 of 1257
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Regulation of the neuronal SNARE-complex by accessory proteins
(2018-02-16)In this work, I have thoroughly characterized a novel complex containing syntaxin1a (1-288), SNAP25a and Munc18-1 and established it as an efficient acceptor complex for synaptobrevin-binding, using several biochemical and ... -
Regulation of vesicular trafficking in presence of mutations in contractile proteins
(2022-06-20)The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ... -
Regulatory interactions of enzymes of the citric acid cycle in Bacillus subtilis
(2013-01-25)In most organisms the tricarboxylic acid (TCA) cycle is a fundamental hub in metabolism. The TCA cycle is the origin and the endpoint of a broad spectrum of intermediates and provides the cell with energy and cellular ... -
Release of a Natural mRNA During Recycling of the Prokaryotic Ribosome
(2023-06-20)Ribosome recycling is the last step of the bacterial translation cycle. The release of the peptide leaves a 70S ribosome with a deacylated tRNA in the P site and the stop codon of the mRNA in the A site. The combined action ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Representation of individual finger movements in macaque areas AIP, F5 and M1
(2019-05-21)The goal of this study was to investigate how individuated finger movements are coded in area AIP, F5 and M1. At the single neuron level, most of the units in all three areas were “broadly tuned”, responding during multiple ... -
Requirements for pre-catalytic B complex formation during exon- and intron-defined spliceosome assembly
(2015-10-07)In eukaryotes, most protein-coding genes are interrupted by non-coding sequences known as introns. The splicing of intronic sequences from a pre-mRNA is catalyzed by the spliceosome, an elaborate molecular machine formed ... -
Residue level characterization of molecular interactions of intermembrane space domains governing the preprotein import into the mitochondrial matrix
(2014-12-10)Mitochondrial matrix targeting proteins are translated as preproteins (carrying an N-terminal 20-50 residue presequence) in the cytoplasm. Post-translationally, they are imported into the mitochondrial matrix through ... -
RESOLFT nanoscopy with water-soluble synthetic fluorophores
(2018-01-17)Fluorescence microscopy is an important and widely used tool in the life sciences due to its unique ability to observe cellular processes in living specimens with target-specific image contrast. The development of high ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Resolving Dopamine Secretion at Individual Varicosities using Carbon Nanotube-Based Optical Dopamine Nanosensors
(2021-07-23)Dopamine (DA) is a neurotransmitter that controls vital brain functions such as motor control and motivation, but little is known about the molecular mechanisms that control DA release. Neurotransmission through DA differs ... -
Revealing structure in vocalisations of parrots and social whales
(2018-08-06)This thesis proposes methods to investigate structure in bioacoustic signals. For this two frameworks are proposed. The first concerns the automatic annotation of audio recordings by using supervised machine learning ... -
Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Ribosome dynamics during spontaneous frameshifting
(2022-10-18)During protein synthesis, the ribosome moves along the mRNA in steps of three nucleotides at a time to maintain the translational reading frame. However, on some mRNA sequences that are denoted as slippery, ribosomes may ... -
Ribosome Processivity and Co-translational Protein Folding
(2017-04-21)Synthesis of polypeptide chains on the ribosome occurs at a non-uniform rate. mRNA sequences translated at a high rate are interspersed by segments that lead to translational pausing. The rate of translation elongation is ... -
RNA Interactions of the Zebrafish Germ Plasm Organizer Bucky ball
(2023-07-24)Reproduction is the fundamental feature of all living organisms, ensuring their survival and continuance. For their reproduction, multicellular organisms develop highly specialized cells, termed germ cells. In many animals, ... -
Role of 5-FU in DNA double strand break repair for improved targets in colorectal cancer therapy
(2015-04-14)Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the world, and 5-Fluorouracil (5-FU) based regimens are chiefly employed for its therapy. Modern regimens, based on 5-FU in combination with ... -
Role of adhesion proteins Neuroligin 2 and IgSF9b in the amygdala anxiety circuitry
(2018-04-23)Anxiety disorder is a debilitating condition that affects up to 10% of the adult population in the world. Mapping of brain activity in patients and in mouse models has shown that anxiety- related behavior is associated ... -
Role of alternative splicing in the biological properties of the voltage-gated potassium channel Kv10.1
(2014-06-02)In the past few years, several publications highlighted the role of alternative splicing as additional source of modulation of ion channels activity. E65 and E70 (also termed as KV10.1Δ4-7 and KV10.1Δ4-9) represent two ... -
Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ...