Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 918-937 of 1263
-
Role of adhesion proteins Neuroligin 2 and IgSF9b in the amygdala anxiety circuitry
(2018-04-23)Anxiety disorder is a debilitating condition that affects up to 10% of the adult population in the world. Mapping of brain activity in patients and in mouse models has shown that anxiety- related behavior is associated ... -
Role of alternative splicing in the biological properties of the voltage-gated potassium channel Kv10.1
(2014-06-02)In the past few years, several publications highlighted the role of alternative splicing as additional source of modulation of ion channels activity. E65 and E70 (also termed as KV10.1Δ4-7 and KV10.1Δ4-9) represent two ... -
Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ... -
Role of BRD4 and histone acetylation in estrogen receptor-positive breast cancers
(2015-09-10)The estrogen receptor-α (ERα) acts as a nuclear transcription factor to promote estrogen-induced transcription and plays a central role in the progression of ER-positive tumors. ERα binds to the consensus DNA elements ... -
Role of cellular dynamics, adhesion and polarity in the context of primordial germ cell migration in Xenopus laevis embryos
(2014-02-11)Directional cell migration is an intensively studied process relevant for both normal development of an organism as well as for a number of pathological conditions such as chronic inflammation and cancer. Primordial germ ... -
Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ... -
Role of DLG-MAGUKs in surface NMDAR localization and its patho-physiological functions
(2014-10-16)The post-synaptic side of an excitatory synapse is characterized by an electron-dense, highly dynamic architecture of proteins, called the post-synaptic density or PSD. PSDs comprises of a diverse group of proteins, from ... -
Role of endogenous retrovirus promoter activity in tumor suppression
(2015-06-03)Roughly 8% of the human genome consists of human endogenous retroviruses (HERVs). They are believed to be remnants of ancient retroviral infections of the germline that were passed on from one generation to the next over ... -
Role of Histone Metabolism and Chromatin Structure in DNA Repair
(2014-06-11)During the cell cycle progression, synthesis of new histones is important to pack newly synthesized DNA and to maintain proper chromatin structure. Unlike normal mRNAs, mRNAs from replication-dependent histone genes that ... -
Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory
(2012-06-06)Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. ... -
Role of internal mRNA modifications in modulating translation elongation
(2024-09-26)Translation is a highly regulated process that defines the composition of the cellular proteome. Numerous mechanisms are known to fine-tune the translational output at different cellular conditions. Recently, a new regulatory ... -
Role of mechanosensitive ion channels in coordinated epithelial cell dynamics in Drosophila
(2019-11-20)Epithelial cells are able to sense and mechanically respond to the forces and movements generated and transmitted through their neighbors. These forces are multicellular at the tissue level, and are transmitted via multimeric ... -
Role of methyltransferases in fungal development and secondary metabolite production
(2014-02-17)Fungal development and secondary metabolism are controlled by environmental signals through regulatory proteins. VeA protein is the founding member of the velvet superfamily of fungal regulators. It is involved in light ... -
Role of microglia in myelin turnover
(2016-07-11)During development oligodendrocytes in the central nervous system (CNS) produce large amount of membrane to generate myelin which wraps around the axons. The synthesis, maintenance and turnover of such enormous amounts of ... -
Role of Munc13 Isoforms in Regulating Large Dense Core Vesicle Exocytosis in Chromaffin Cells
(2015-11-03)The process of vesicular exocytosis is a fast, tightly regulated and Ca2+-triggered event mediated by SNARE complex formation. Although it is known that factors like Munc18, Munc13 and CAPS are important in setting up ... -
Role of Neuroligins at the Inhibitory Postsynaptic Compartment of the Retina
(2010-06-15)Neuroligins are postsynaptic cell adhesion proteins central to synapse maturation and function.There are four isoforms of Neuroligins (1 4) expressed in the rodent brain. Neuroligins 1 and ... -
Role of predisposing genetics, telomere signaling and crosstalk of cardiac fibroblasts and cardiomyocytes in a pluripotent stem cell model of dilated cardiomyopathy
(2023-02-16)Despite rapid scientific and medical advances, cardiovascular diseases represent a major threat to human health worldwide. Among these, cardiomyopathies are one of the leading causes of heart failure. Dilated cardiomyopathy ... -
Role of prion protein in synucleinopathies
(2020-06-11)Synucleinopathies comprise a group of neurodegenerative diseases, characterized by deposits of aggregated alpha-synuclein (aSyn) in neurons and glia. The special hallmark is the presence of Lewy bodies and Lewy neuritis, ... -
Role of PSD-95 in mouse binocular vision: A combined behavioural and 2-photon Ca2+ imaging study
(2025-10-22)Visual cortical circuits undergo a temporally restricted period of heightened plasticity early in neurodevelopment, termed the critical period (CP; Hubel and Wiesel, 1962, 1963). Crucial visual abilities, such as binocularity, ... -
Role of PSD-95 in synaptic maturation and visual cortex plasticity
(2014-08-29)PSD-95 belongs to the family of DLG-MAGUKs (Discs-large membrane-associated guanylate kinases), and it plays an important role in organizing postsynaptic signaling and synaptic transmission in excitatory synapses. The ...