Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 938-957 of 1267
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Role of prion protein in synucleinopathies
(2020-06-11)Synucleinopathies comprise a group of neurodegenerative diseases, characterized by deposits of aggregated alpha-synuclein (aSyn) in neurons and glia. The special hallmark is the presence of Lewy bodies and Lewy neuritis, ... -
Role of PSD-95 in mouse binocular vision: A combined behavioural and 2-photon Ca2+ imaging study
(2025-10-22)Visual cortical circuits undergo a temporally restricted period of heightened plasticity early in neurodevelopment, termed the critical period (CP; Hubel and Wiesel, 1962, 1963). Crucial visual abilities, such as binocularity, ... -
Role of PSD-95 in synaptic maturation and visual cortex plasticity
(2014-08-29)PSD-95 belongs to the family of DLG-MAGUKs (Discs-large membrane-associated guanylate kinases), and it plays an important role in organizing postsynaptic signaling and synaptic transmission in excitatory synapses. The ... -
Role of Rho GTPases During Primordial Germ Cell Migration in Zebrafish
(2008-11-26)Cell migration is an essential biological process during development, adult homeostasis, and disease. Actin cytoskeleton plays crucial role in generating forces required for cell migration. ... -
Role of Serine hydroxymethyltransferase in cell cycle control and early Drosophila development
(2016-10-10)The early development of Drosophila melanogaster occurs in a syncytium, where nuclei undergo mitotic divisions without accompanying cytokinesis. Early cleavage cycles are very short and consist only of S and M phases. In ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
Role of the nuclear lamina for stem cell mediated homeostasis
(2016-11-22)The nuclear lamina is a protein meshwork at the inner side of the inner nuclear membrane and connects to essential cellular structures like chromatin, the nuclear pore complex and the cytoskeleton. The nuclear lamina is ... -
Role of WRB protein in cardiac function
(2017-08-24)The mammalian TRC40 system is a conserved pathway responsible for the post-translational targeting of tail-anchored proteins, which are characterized by a single transmembrane domain at the C-terminus and an N-terminus ... -
Roles of miR-137 in Muscular Dystrophy and Muscular Dystrophy-Related Phenotypes in Drosophila melanogaster
(2019-05-07)Muscular dystrophies (MDs) are a group of diseases that cause muscular and neurological disorders in human patients. They are associated with a multi-component complex called the Dystrophin Glycoprotein Complex (DGC). The ... -
Roles of PSD-93 and environmental enrichment in cortical synapses
(2015-11-10)During neurodevelopment several structural, molecular and functional changes take place in the brain to promote its maturation. These changes occur at multiple levels, including changes in protein expression, in the strength ... -
Roles of the HECT-Type Ubiquitin E3 Ligases of the Nedd4 and WWP Subfamilies in Neuronal Development
(2015-05-21)Protein ubiquitination is a core regulatory principle in neuronal development. In this study, I used brain specific KO mice to investigate the roles of several HECT-type Nedd4 superfamily E3 ligases, i.e. Nedd4-1, Nedd4-2, ... -
Roles of the Nedd4 Family E3 Ligases in Glial Function and Nerve Cell Development
(2017-05-09)Protein ubiquitination is one of the core regulatory post-translational modification in neuronal development. In this study, we used brain specific KO mice to identify novel substrate proteins of several Nedd4 family E3 ... -
Roles of α-neurexins in synapse stabilization and Ca<sup>2+</sup>-dependent endocrine secretion
(2007-04-27)α-Neurexins are synaptic cell-surface molecules that are required for neurotransmitter release at synapses. Deletion of multiple α-neurexin genes in mice leads to premature lethality of ... -
Salicylic Acid (SA)-independent processes in Systemic Acquired Resistance (SAR)
(2021-03-25)SAR is an immune response that is established in the systemic leaves after infection of local leaves with biotrophic or hemibiotrophic pathogens. According to the current model, the amino acid-derived metabolite ... -
Sarcomere signaling in a patient-specific iPSC model of hypertrophic cardiomyopathy
(2025-03-07)Hypertrophic cardiomyopathy (HCM) is a severe cardiac disorder associated with ventricular hypertrophy, diastolic dysfunction, and arrhythmias, which can lead to heart failure. Inherited forms of HCM are frequently caused ... -
Scale-dependent Response of Fluid Turbulence under Variation of the Large-scale Forcing
(2016-02-03)In this work, an experiment to measure the temporal evolution of energy transfer at different scales in a turbulent flow that was subject to a perturbation of the energy injection is described. Two types of experiments ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
Schwann cell differentiation in Charcot-Marie-Tooth disease 1 A (CMT1A)
(2019-04-11)Charcot–Marie–Tooth disease is the most common inherited neuropathy and a duplication of the peripheral myelin protein 22 gene (PMP22) causes the most frequent sub-form Charcot–Marie–Tooth 1A (CMT1A). In contrary to the ... -
Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling
(2014-07-31)The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as ... -
Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach
(2013-01-04)The members of the Sec1p/Munc18 (SM) family of proteins are indispensible regulatory elements that act at the post-docking step prior to fusion; they exert their function mainly through their interaction to the Qa-SNAREs ...