Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 984-1003 of 1218
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Structural and Functional Investigations of Transmembrane Signaling Histidine Kinase Using NMR
(2022-11-04)Membrane proteins play a central role in biology as the gatekeepers of all cellular compartments. And transmembrane signaling through membrane bound kinases is a particularly important process for cellular adaptation to a ... -
Structural and functional studies of eukaryotic translation initiation factors
(2014-08-19)Protein synthesis can be divided into three distinct subprocesses, namely initiation, elongation and termination. During the initiation phase, the elongation competent ribosome, which harbors the initiator tRNA in its ... -
Structural and functional studies of RNA polymerase II passage through nucleosomes
(2024-03-05)Transcription by RNA polymerase II (Pol II) is an essential process of life occurring in the context of the compact eukaryotic nucleus. While transcription elongation has been extensively studied on linear DNA in vitro, ... -
Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2
(2013-06-25)The spliceosome is a highly dynamic, multi-MDa eukaryotic RNA-protein (RNP) machinery that catalyzes precursor messenger RNA (pre-mRNA) splicing. Pre-mRNA splicing entails the excision of non-coding introns and the joining ... -
Structural Characterization of Proteasome Inhibition
(2017-08-15)The proteasome plays a major role in non-lysosomal protein degradation pathways and inhibition of proteasomes became a valid therapeutic strategy for anti-cancer therapy in the recent years. Current efforts focus on the ... -
Structural Characterization of the Eukaryotic Translation Initiation by Electron Cryo-Microscopy
(2019-05-08)Translation is a highly conserved molecular process during which the genetic information stored in an mRNA molecule is translated into a polypeptide chain that eventually folds into functional three-dimensional proteins. ... -
Structural determinants of voltage-dependent gating of Kv10.1
(2022-01-07)Voltage-gated ion channels sense voltage through the movement of the voltage sensor in response to change in membrane potential, hence influencing the channel pore. In this project, we seek a deeper understanding of ... -
Structural insight of MODAG-005 on 𝛼-Synuclein aggregates as a novel PET tracer
(2024-11-15)Neurodegenerative disorders, including Parkinson's disease (PD) and related synucleinopathies, are characterized by the accumulation of pathological protein aggregates in the brain. Among the key proteins implicated in ... -
Structural insights into Arginine-Serine rich proteins and N-H spin-spin coupling constants
(2013-11-27)This thesis is constituted of two parts. In the first part of this thesis, I studied the structural phenomena of SR protein phosphorylation. The serine/arginine-rich (SR) protein family plays multiple functions in the whole ... -
Structural Insights into Early Spliceosome Assembly by cryo-EM
(2021-12-23)In eukaryotes, splicing is a process during which the non-coding introns of the pre-messenger RNA (pre-mRNA) are removed, and the protein-coding exons are ligated. The introns are defined by conserved 5' splice site (5'SS), ... -
Structural interrogation of enzyme mechanism and dynamics
(2023-05-05)The pyruvate dehydrogenase complex (PDHc) is one of the largest macromolecular enzyme complexes, and serves an universally important metabolic function by converting pyruvate into acetyl-CoA. Therefore, the PDHc connects ... -
Structural investigation of functional nucleic acids
(2021-06-30)DNA enzymes, also known as deoxyribozymes, are synthetic single-stranded DNA molecules able to catalyze chemical reactions. There are two main reasons for studying deoxyribozymes: their practical value in various applications, ... -
Structural investigation of the histone chaperone complex FACT using genetically encoded crosslinkers in Saccharomyces cerevisiae
(2015-10-23)Chromatin is a highly dynamic nucleoprotein structure that stores the eukaryotic genetic information. Histones are the essential chromatin proteins that form the core octamers around which DNA is compacted within the ... -
Structural studies of RNA polymerase II complexes with human TFIIS and capping enzymes
(2023-12-14)Transcription is a conserved fundamental cellular process carried out by RNA polymerases (Pol) that results in the synthesis of an RNA transcript. Transcription of protein coding genes by Pol II is the first step in ... -
Structural Studies on Transmembrane Signalling Mechanism of Histidine Kinase CitA
(2019-12-18)Perception of environmental changes and subsequent signal transduction are key aspects for the survival of an organism. In bacteria, two component systems (TCSs) consisting of a homodimeric receptor histidine kinase (HK) ... -
Structural Survey on Cohesin and Viomycin Inhibited 70S Ribosome by Single Particle Electron Microscopy
(2016-04-21)Life can be understood as the systematic collaborative action of several entities on molecular level reducing locally the entropy at the cost of the exterior environment. These entities are in great part macromolecular ... -
Structural, biochemical and computational studies on PROPPINs, proteins important in autophagy
(2015-12-16)PROPPINs (β-propellers that bind polyphosphoinositides) are conserved eukaryotic proteins that play an important role in autophagy. Yeast contains three PROPPINs: Atg18, Atg21 and Hsv2 (homologous with swollen vacuole ... -
Structure and Biochemistry of otoferlin C2-domains
(2011-10-25)Since the necessity of functional otoferlin for normal hearing has been discovered, the role of this protein in inner hair cell exocytosis is subject of intense studies. In this thesis, the ... -
Structure and biochemistry of polyunsaturated fatty acid double bond isomerase from Propionibacterium acnes
(2007-12-06)Conjugated linoleic acid (CLA) is a collective term describing positional and geometrical isomers of linoleic acid (LA, 18:2delta9Z,delta12Z). This class of compounds is receiving much ... -
Structure and dynamics of artificial lipid membranes containing the glycosphingolipid Gb3
(2015-09-07)The lateral structure of the plasma membrane of mammalian cells is governed by the underlying actin cytoskeleton and the complex composition of the membrane. Using phase-separated membranes of the raft-like mixture ...