Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Issue Date
Now showing items 21-40 of 1169
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Mechanistic Characterization of CDK9 Inhibition in T-Cell Lymphoma
(2024-08-20)Mature T-cell lymphomas (mTCL) comprise a rare group of lymphoid malignancies with very diverse genetical, clinical, and pathological characteristics that are in many cases associated with poor prognosis. Current therapy ... -
Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Investigations of signal-enhanced magnetic resonance contrast agents
(2024-08-15)Nuclear magnetic resonance spectroscopy (NMR spectroscopy) and its related technique, magnetic resonance imaging (MRI), enable scientists and doctors to make statements about the atomic structure of a sample and to ... -
Computational methods for prokaryotic (meta)genomic annotation and function prediction using horizontal information transfer
(2024-08-05)In recent decades, there has been a surge in genomic sequences resulting from large-scale genomic and metagenomic sequencing projects, driven by the significant drop in sequencing costs. More powerful methods to annotate ... -
Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Improving Cognition in Older Adults Through Transcranial Electrical Stimulation And Cognitive Training
(2024-07-23)The progressive aging of the global population continues unabated. Consequently, there is a substantial increase in the prevalence of neurocognitive disorders, primarily observed in the elderly. Current pharmacological ... -
Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis
(2024-07-23)Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ... -
Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV)
(2024-07-23)Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ... -
Function and homeostasis of non-proteinogenic amino acids in Bacillus subtilis
(2024-07-23)The gram-positive soil bacterium Bacillus subtilis lives in a constantly changing environment, requiring rapid adaptation to survive and thrive. This forces the bacteria to adapt to nutrient availability or stressful ... -
UV and chemical crosslinking mass spectrometry for the analysis of protein-nucleic acid interactions
(2024-07-12)Protein-nucleic acid interactions are a key part of essential cellular processes and their disturbance often results in the development of diseases. Crosslinking mass spectrometry (XL-MS)-based approaches have become ... -
Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning
(2024-07-09)Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ... -
A crosstalk between NF-κB and STAT1 signal transduction pathways in ischemic and proliferative diseases
(2024-07-08)The cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) executes anti-microbial and pro-apoptotic functions, while loss-offunction mutations in the STAT1 gene are associated with ... -
Behavioral analyses in translational neuropsychiatric research
(2024-07-05)Cognitive impairment frequently co-occurs in a variety of neuropsychological disorders, making it an increasing burden to the affected individuals, their relatives, and society in general. Diagnostic procedures usually ... -
Functional Annotation of Gretchen Hagen 3 Enzymes
(2024-07-05)Plants employ a multitude of phytohormones to regulate all aspects of their physiology ranging from their development to specific, environment-dependent responses to threats and other cues. The integration of all these ... -
Proactive planning of action sequences
(2024-07-05)Everyday tasks often require a sequence of actions. Knowing which actions will follow, allows us to proactively prepare for subsequent actions before the first action has been executed. This thesis investigated the neural ... -
Developing tools for translational In-vivo cochlear optical stimulation
(2024-07-02)Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ... -
Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
Investigation of a putative circuit in the mouse retina
(2024-06-27)Retinal ganglion cells of the vertebrate retina are tuned to detect specific features of the visual scene and effectively decompose it into different channels that are transmitted to and used by the brain to create the ... -
Conservation and divergence of the retinal homeobox genetic neural lineage between Drosophila melanogaster and Tribolium castaneum
(2024-06-25)Brains are the central organ integrating sensory information and orchestrating behaviour. Their function and development are of great scientific interest, but their enormous complexity makes them difficult to study. The ...