Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Issue Date
Now showing items 21-40 of 1263
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Transgenic fungal expression and characterization of a fluorescently-tagged variant of the Verticillium effector protein TRADEVd, and functional elucidation of its Fusarium homolog TRADEFo, and of another Verticillium effector candidate, LSCE1Vd
(2025-09-11)Vascular wilt fungi have an arsenal of secreted effector proteins, which manipulate the host physiology and immune system for their successful colonization. Among these effectors, Verticillium TRADEVd was previously ... -
Decoding Courtship Dynamics: The Role of Behavioral Rules, Feedback Cues and Internal State in Drosophila Interactions
(2025-08-29)The behavior of an organism is the result of sensorimotor transformations (behavioral rules) by which the brain integrates external sensory stimuli with its internal state to control a motor output and elicit a particular ... -
Development and Application of Camelid Single-Domain Antibodies for Live and Multiplexed Imaging of Synaptic Structure and Function
(2025-08-29)Optical microscopy has become one of the most powerful tools in biology, allowing the visualization of cells, subcellular structures, and molecular interactions, leading to a number of groundbreaking discoveries. Since the ... -
Effects of perturbed sumoylation and neddylation on synaptic transmission
(2025-08-22)Post-translational modifications (PTMs) regulate a wide range of cellular processes. PTMs involving ubiquitin-like modifiers (UBLs) have been implicated in neurodevelopment and brain diseases. Recent evidence indicates ... -
Understanding Visual Attention: A Multifaceted Approach
(2025-08-21)We all have an intuitive sense of what attention is, yet defining it precisely remains challenging. While research in psychology and neuroscience has explored its origins, mechanisms, and influence on behaviour for over a ... -
Mitochondrial Alterations in Rett Syndrome
(2025-08-19)Rett syndrome is a neurodevelopmental disorder and one of the primary causes of cognitive impairment in females. Affected individuals typically exhibit normal development until 6-18 months of age, followed by stagnation ... -
Cytoskeletal networks in living cells under strain
(2025-07-15)The eukaryotic cytoskeleton consists of three types of filamentous proteins: actin filaments, microtubules and intermediate filaments (IFs). In contrast to actin and tubulin, IF proteins are expressed in a cell-type specific ... -
Transaldolase from Thermoplasma acidophilum: new reactivities and applications in biocatalysi
(2025-06-27)In this PhD thesis, the enzyme transaldolase from the thermophilic organism Thermoplasma acidophilum (TacTAL) was studied from two related perspectives: its reactivity toward 5-carbon phosphosugars and its potential ... -
Multisensory integration of courtship song and taste in male Drosophila melanogaster social behavior
(2025-06-24)The integration of sensory information is essential for animals to effectively navigate and interact in their environment. For instance, the social life of male fruit flies is surrounded by various sensory modalities ... -
Mechanism, regulation and structure of human pyruvate dehydrogenase complex
(2025-06-23)The human pyruvate dehydrogenase complex (hPDHc) catalyzes the irreversible conversion of pyruvate to acetyl-CoA, linking glycolysis to the citric acid cycle - a central hub of cellular metabolism. This reaction proceeds ... -
Pharmacotherapeutic approaches against Plasmodium falciparum
(2025-06-23)Malaria tropica persists as one of the most impactful infectious diseases, threatening the health of nearly half of the world’s population every year. The disease is caused by Plasmodium falciparum (P. falciparum), a ... -
High-resolution morphometric analysis of synaptic vesicle formation
(2025-06-23)Synaptic vesicle (SV) biogenesis plays an important role in neurotransmission, yet the intricacies of SV formation remain a significant scientific challenge. In this PhD thesis, I seek to address both technical and biological ... -
Flexibility and optimization of neural codes in primate sensory cortex
(2025-06-18)Flexibility and efficiency are core characteristics of any intelligent system. We have a remarkable capacity to continually learn from the structure in the world, predict upcoming situations and flexibly respond in a ... -
Deciphering novel pathomechanisms initiating and maintaining atrial fibrillation
(2025-06-17)Atrial fibrillation (AF) is the most common arrhythmia and AF burden is projected to rise in the next years. This may be partially attributed to limited efficacy of current antiarrhythmic therapies and interventions. A ... -
SNARE Cis-Reassembly: Investigating SNARE Interactions Post-Disassembly
(2025-06-16)Neurotransmitter release relies on the SNARE-mediated fusion of neurotransmitter-filled synaptic vesicles with the presynaptic plasma membrane. SNARE proteins from these opposing membranes interact to form a stable ... -
Inferring spreading dynamics of diseases and in neural networks
(2025-06-11)The rapid advancement in information technology over the past few decades has provided ample computational power and access to diverse data sources. In conjunction with recent inference methods, we can now examine the ... -
Protein Mobility in the Complex Physical Environment of the Synapse
(2025-05-22)Robust signal transmission between cells is vital for our daily lives. It relies on fine orchestration of many processes, particularly taking place at chemical synapses. Here, chemical reactions occur in precise order, ... -
Investigations of Signal-Enhanced Magnetic Resonance Contrast Agents
(2025-05-22)The subject of this thesis is to extend the scope of magnetic resonance imaging (MRI) to the visualization and characterization of metabolic activities. The inherent insensitivity of conventional MRI limits its applicability ... -
Structural and Mechanistic Interrogation of Fatty Acid Biosynthesis Machinery
(2025-05-22)Lipids are important molecules for vital functions in the cell, such as energy storage, membrane structure, cellular signaling, and metabolic control. Lipid metabolism is thus one of the central pathways of all living ... -
Computational Methods for Canonical and Noncanonical Peptide Identification in Immunopeptidomics
(2025-05-19)The presentation of peptides via the MHC-I pathway as signals to CD8+ T cells is an essential element of the adaptive immune system. Hence, effective identification of the peptides presented (i.e., the MHC-I immunopeptidome) ...