Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Erscheinungsdatum
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Collective Behaviour of Filamentous Cyanobacteria
(2024-01-11)Cyanobacteria are the oldest phototrophic organisms on the planet. Having been responsible for the “Great Oxidation Event” millions of years ago, it has enabled the development and sustenance of multi-cellular life forms, ... -
CFM: Confinement Force Microscopy-a dynamic, precise and stable microconfiner for traction force microscopy to study confined cell behaviour
(2024-01-11)Physical properties of the 3D microenvironment and the residing tissue affect cell behavior and function. 3D environment represents major physical obstacles for cell migration, such as spatial confinement, which could ... -
Influence of Interictal Epileptiform Activity on Language Networks in Children with Rolandic Epilepsy or Dyslexia
(2024-01-05)Self-limited Epilepsy with Centrotemporal Spikes (SeLECTS) is the most common genetic epilepsy in children. It is characterized by seizures remission in puberty and highly frequent interictal epileptiform discharges (IEDs) ... -
Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ... -
Information, Logic, and Inference in the Analysis of Complex Networks
(2023-12-22)This thesis deals with a range of current topics in information theory and statistics. It consists of five distinct contributions: Chapter 2 focuses on the statistics of single-regression Granger causality estimators. ... -
A comprehensive study of the adult mouse brain transcriptome: analysis of inter-individual differences in cognitive aging and cell-type specific changes in the hippocampus upon voluntary exercise
(2023-12-19)The hippocampus (HPC) is a brain region crucial for learning and memory processes, and this link between the HPC and cognition has been extensively studied in recent decades. Previous research has demonstrated that external ... -
Structural studies of RNA polymerase II complexes with human TFIIS and capping enzymes
(2023-12-14)Transcription is a conserved fundamental cellular process carried out by RNA polymerases (Pol) that results in the synthesis of an RNA transcript. Transcription of protein coding genes by Pol II is the first step in ... -
Functions of cytoplasmic lattices in mammalian oocytes and embryos
(2023-12-12)Preimplantation embryogenesis is dependent on maternally stored proteins, transcripts, and other macromolecules. Although this is a well-established dogma, it is unclear how mammalian oocytes store maternal factors needed ... -
Neural correlates of action effects anticipation – towards ecological more relevant paradigms
(2023-12-07)Imagine it is Saturday morning and you are going for groceries with your car. Once you arrive at the supermarket, you attempt to reverse park your car in a narrow parking space. You have learned in school, if you want ... -
Genomics of Hybridization and Adaptation in Primates
(2023-12-07)In chapter 1, we used high coverage (30X) whole genome sequences from 225 wild baboons (genus Papio) representing 19 geographic localities to investigate population genomics and inter-species gene flow. Our analyses provide ... -
Streptophyte evolution: plastidial signals and core abiotic stress physiology of the closest algal relatives to embryophytes
(2023-12-04)Plant terrestrialization facilitated the emergence of the enormous and diverse macroflora. It changed the face of our planet. On this singular evolutionary event, which occurred approximately 550 million years ago, land ... -
Synthesis of molecular probes for the hyperpolarization with parahydrogen
(2023-11-28)Nuclear magnetic resonance spectroscopy (NMR) and related nuclear magnetic resonance imaging (MRI) allow us to acquire information about molecules at an atomic level and thereby create images of human tissues and organs ... -
The role of pulvinar-parietal circuitryin goal-directed saccades
(2023-11-28)The pulvinar, an important higher-order thalamic nucleus supporting many functions, is reciprocally connected with frontoparietal areas involved in sensorimotor transformations. Priorperturbation studies also revealed its ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ... -
Structural and functional investigation of tRNA guanine transglycosylase
(2023-11-17)In this thesis, two novel structures were presented, jointly illuminating dimerization and tRNA binding by human TGT. A first structure, obtained by X-ray crystallography, allowed to give a thorough account of the atomic ... -
Force information integration in the primate fronto-parietal reach network
(2023-11-10)The primate sensorimotor system relies on force predictions, when executing a motor command with a certain force. Yet it remains unclear if the sensorimotor system uses these force predictions to prepare a motor command ... -
Regulation of plant stress responses by clade I TGA transcription factors and interacting CC-type glutaredoxins
(2023-11-09)TGACG-BINDING (TGA) transcription factors are important regulators in numerous processes such as pathogen defense, development and detoxification. To control some of these responses, plant specific CC type glutaredoxins ... -
Giant plasma membrane vesicle-derived in vitro systems to study the structure and dynamics of CaV1.3 channel clusters
(2023-11-06)The voltage-gated calcium channel 1.3 (CaV1.3) has plentiful tasks in the human body. One of them is the excitation-contraction coupling within the heart, where it is known to form CaV1.3 channel cluster. However, their ... -
A theory of inference and learning in cortex with spiking neurons and dendritic error computation
(2023-11-03)How the cortex performs its intricate computations, and how it adapts to the world around it, is one of the central mysteries in neuroscience. It is a longstanding belief that one of the main aims of the brain, and especially ... -
Proteomic Profiles of Campylobacter jejuni and Enterococci during Co-incubation and under Bile Acid Stress
(2023-11-03)The human gut harbors a complex ecosystem of microbial communities, consisting of commensal inhabitants, which play crucial roles in maintaining gut homeostasis, regulating host metabolism, and modulating immune responses. ...