Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Issue Date
Now showing items 21-40 of 1222
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Perceptual Misbinding of Color and Motion - Visual Feature Integration in Humans and Macaques
(2025-02-24)To interact with our environment, sensory signals must be translated into perceptions that guide our behavior. However, our noisy, crowded, and dynamic environment provides too much information to process. As a result, our ... -
Thalamic Contributions to Internal Models for Motor Control
(2025-02-24)The ability of the motor system to control movements ensures successful goal-directed actions through our interaction with the environment. Motor adaptation is a process through which we maintain and adapt the existing ... -
Disinhibitory circuit motifs in the mouse primary somatosensory (barrel) cortex
(2025-02-24)The barrel cortex is the part of the rodent neocortex where the tactile information from the whiskers is processed. In the barrel cortex, each whisker is represented by a single cortical column isomorphic to the whiskers ... -
Auditory nerve function in mouse models of ATP11A and CABP1-CABP2 related hearing loss
(2025-02-10)Hearing loss can be caused by varied factors affecting diverse structures of the auditory system such as the middle ear, the stria vascularis, the outer hair cells (OHC), inner hair cells (IHC), the spiral ganglion neurons ... -
Fluorescence Correlates of Single Vesicles to Analyze the Behavior of Membrane-manipulating Proteins
(2025-01-24)Soluble NSF-attachment protein receptors (SNAREs) are integral to eukaryotic membrane fusion, providing the necessary energy to surmount the repulsive forces between two opposing membranes. This is achieved through the ... -
The role of RNA in synaptic physiology and neurodegeneration in synucleinopathies
(2025-01-23)Synucleinopathies are neurodegenerative disorders characterised by the pathological accumulation and aggregation of the protein alpha-synuclein (aSyn). Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), multiple ... -
From a First Seizure to Chronic Epilepsy – A Structural and Functional Study
(2025-01-23)Diagnosing epilepsy after a first unprovoked seizure is challenging, especially in patients without detectable lesions on standard magnetic resonance imaging (MRI) and without interictal epileptiform discharges (IEDs) ... -
The role of Hsp42 in proteostasis-metabolism interplay and cellular longevity
(2025-01-23)Aging is a natural phenomenon characterized by a progressive decline despite complex pathways of maintenance and repair. Over time, cells experience profound changes in cell morphology as well as alterations in gene ... -
What an Insect Brain Can Tell Us: The Impact of Intrinsic and Extrinsic Factors on Long-Term Memory in Drosophila melanogaster Larvae
(2025-01-10)Learned associations can be consolidated into long-lasting memory traces, influenced by the relevance and abundance of information, as well as internal states of the animal. In adult Drosophila two distinct forms of ... -
Structure, Mechanism and Regulation of human UMP Synthase
(2025-01-10)Enzymes are of critical importance for a large range of biochemical reactions, catalyzing the conversion of a substrate to a product by lowering the energy of the transition state. The resulting rate acceleration in ... -
Strategies for decreasing aneuploidy in mammalian oocytes
(2025-01-10)Female mammals experience a decline in fertility with age that has been attributed to the progressive depletion of the finite ovarian reserve and an increase in the incidence of aneuploid oocytes. Aneuploid oocytes can ... -
Rate-limiting steps of autophagy initiation
(2024-12-23)Autophagy research has progressed tremendously since the identification of ‘ATG’ genes and proteins responsible for maintaining the process. A dissection of general functions of all proteins involved was possible. However, ... -
Molecular mechanisms and cellular functions of RNA methyltransferases targeting non-coding RNAs
(2024-12-23)Cellular RNAs contain diverse modified nucleotides that regulate their structure, stability, biogenesis and molecular functions. In abundant non-coding RNAs such as ribosomal (r)RNAs, transfer (t)RNAs and small nuclear ... -
Investigation of the dual role of mL62 during the mitoribosome assembly and rescue
(2024-12-19)Mitochondria are eukaryotic organelles, which have their own DNA (mtDNA) that encode for 13 proteins that are essential for the oxidative phosphorylation. The mitochondrial ribosome (mitoribosome) is responsible for the ... -
Characterization of VAPA at the inner nuclear membrane: localization, membrane insertion and nuclear interactome
(2024-12-19)Tail-anchored (TA) proteins are type IV single-pass membrane proteins characterized by a long hydrophobic transmembrane domain (TMD) positioned very close to a notably short C-terminus facing the lumen. Due to their topology, ... -
Mechanisms of Ribosomal Translation studied by Molecular Dynamics Simulations
(2024-12-17)During translation, the ribosome moves along the mRNA and decodes the genetic information to synthesize proteins. This process proceeds in a step-wise iterative manner during which the ribosome undergoes conformational ... -
Transport mechanisms of the putative vesicular nucleotide transporter VNUT
(2024-12-13)The vesicular nucleotide transporter VNUT (SLC17A9) is thought to refill recycled synaptic vesicles and other secretory vesicles with adenosine triphosphate (ATP) for chemical signal transmission. ATP translocation by VNUT ... -
The dynamics of singularities in passive, driven, and active matter
(2024-12-13)Out-of-equilibrium statistical physics studies the time evolution of large collections of particles in terms of a reduced number of meso- and macroscopic observables. Their nature emerge from of the underlying microscopic ... -
Mechanisms of chromosome segregation in mammalian oocytes
(2024-12-10)Errors in chromosome segregation in human females often result in eggs with the wrong number of chromosomes, a condition known as aneuploidy. The rate of aneuploidy increases dramatically in women with age, particularly ... -
Advancements in Nanobody Applications: From Live Synaptic Imaging to Multiplexed Fluorescence Microscopy and Nanoscale Topography Mapping
(2024-12-09)Fluorescence microscopy facilitates biological research by enabling straightforward visualization of fluorescently labeled proteins in live and fixed samples. Despite significant progress in microscopy techniques, including ...