Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Issue Date
Now showing items 61-80 of 1182
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Structural and functional connectivity in patients with major depressive disorder undergoing accelerated intermittent theta burst stimulation
(2024-06-05)Major depressive disorder (MDD) is one of the most prevalent mental health conditions, primarily characterized by depressed mood and loss of interest or pleasure. Cognitive impairments, including psychomotor agitation ... -
Reconstruction of Cardiac Wave Dynamics from Mechanical Deformation
(2024-05-24)Cardiac arrhythmias, such as atrial and ventricular fibrillation, are caused by abnormal electrical activity within the heart muscle, leading to irregular contractions and potentially life-threatening situations. Current ... -
A Quantitative Mass Spectrometric Analysis of Signalling Proteins in Human Sperm Cells
(2024-05-17)Fertilization of an oocyte by a sperm cell is a complex multi-stage process. First, a sperm cell must locate and reach the oocyte; second, it must undergo capacitation, the acrosome reaction, and hyperactivation to penetrate ... -
Regulation of the Hrd1 Ubiquitin ligase during protein degradation at the endoplasmic reticulum
(2024-05-16)Misfolded or redundant proteins of the endoplasmic reticulum are degraded via ER associated degradation: They are recognized, undergo a retrotranslocation into the cytosol, become ubiquitinated, are extracted from the ... -
New redox-switches in proteins
(2024-04-26)Regulation of cellular pathways in response to the redox state of a cell is an important regulatory process. A well-established paradigm of redox-sensing is disulfide formation between two cysteine residues and cysteine ... -
Regulation of human 48S initiation complex formation
(2024-04-23)During the initiation phase of protein synthesis in humans, the small ribosome subunit interacts with initiator tRNA (tRNAi) and at least ten different initiation factors (eIFs) to form the initiation complex. The initiation ... -
Saynpatic mechanisms of noise-induced hearing loss
(2024-04-19)Noise-induced hearing loss (NIHL) is a form of acquired hearing impairment, caused by exposure to loud noise, that damages the delicate inner ear structures, possibly including the neural connections between the Inner Hair ... -
Structural and functional analyses of the HECT E3 ligase HACE1
(2024-04-19)Many crucial cellular processes rely on post-translational modifications. In particular, the covalent attachment of ubiquitin molecules, termed ubiquitylation, onto substrates, typically via lysine residues, is most commonly ... -
An investigation of cell turnover in the planarian epidermis
(2024-04-16)Cell turnover is an important biological process for maintaining tissue homeostasis. During cell turnover, newly generated cells replace unwanted cells to balance the number of cells and ensure the functionality of a tissue. ... -
Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ... -
Mechanistic and structural characterization of human L-asparaginases
(2024-04-04)L-asparaginases are therapeutic proteins against acute lymphoblastic leukaemia (ALL), especially in children. As lymphoblastic cells depend on L-asparagine in the blood serum, its depletion by L-asparaginases leads to ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Characterization of testosterone and androgen receptor action in human and rhesus macaque heart muscle cells
(2024-03-26)Androgens are sex steroid hormones that influence various processes in reproductive tissues and peripheral organs. Their lipophilic nature enables free diffusion through the plasma membrane. In the cytoplasm, testosterone ... -
Investigation of OPA1 in Mitochondrial Dynamics and Ultrastructure
(2024-03-21)Mitochondria are highly dynamic organelles with a complex ultrastructure. The mitochondrial inner membrane (MIM) is folded into cristae in which oxidative phosphorylation, a process to generate energy for the cell, takes ... -
Functional Analysis of Paired NLR Immune Receptors in Plant Immunity
(2024-03-21)The Arabidopsis gene AT3G04210 encodes a truncated Toll/interleukin-1 receptor nucleotide-binding leucine-rich repeat (TIR-NB-LRR or TNL) protein that is lacking the canonical C-terminal LRR domain of NLRs, and is named ... -
The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
Structural and functional studies of RNA polymerase II passage through nucleosomes
(2024-03-05)Transcription by RNA polymerase II (Pol II) is an essential process of life occurring in the context of the compact eukaryotic nucleus. While transcription elongation has been extensively studied on linear DNA in vitro, ... -
Mechanisms underlying age-related decline in mammalian female fertility
(2024-03-05)Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Investigating the Ultrastructural Consequences of Aging on Murine Inner Hair Cell Ribbon Synapses
(2024-03-05)The ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are first synapses of the auditory pathway. They mediate the harmonized and tireless neurotransmission needed for continuous sound ...