Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Author "Ludwig, Sebastian"

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Investigation of the effects of the splicing inhibitor Pladienolide B and cancer-related mutations in the SF3b1 protein on pre-mRNA splicing in vitro

Ludwig, Sebastian (2020-06-11)

Pre-mRNA splicing is catalyzed by the spliceosome. A highly dynamic, macromolecular RNP complex is formed out of the U1, U2, U4, U5 and U6 snRNPs and multiple snRNP proteins. During the early stages of spliceosome assembly, ...